Whisky (1 g/kg, 21.5% alcohol) was administered orally to healthy young adult male volunteers, and changes in the plasma concentrations of alcohol, acetaldehyde, gastrin, cholecystokinin (CCK) and serum amylase were measured over time. Values for alcohol and acetaldehyde rapidly reached a peak at 30–45 min after alcohol intake, followed by a gradual decline. The plasma gastrin concentration showed a rapid elevation, while the plasma CCK concentration did not exhibit any significant changes in the early phase after alcohol intake. Elevation of CCK was observed after 75 min, however. These results show that intake of whisky stimulates the secretion of gastrin and is associated with a later increase in CCK.
SteerMLGlazerGManabeT: Direct effects of ethanol on exocrine secretion from the in vitro rabbit pancreas. Dig Dis Sci1979; 24: 769–774.
2.
ManabeT: Effects of in vitro and in vivo ethanol and acetaldehyde on exocrine pancreatic secretion. Nippon Geka Hokan1985; 54: 3–9.
3.
WatanabeOBaccinoFMSteerMLMeddolesiJ: Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis. Am J Physiol1984; 246: G457–G467.
4.
HajnalFFloresMCRadleySValenzuelaJE: Effect of alcohol and alcoholic beverages on meal-stimulated pancreatic secretion in humans. Gastroenterology1990; 98: 191–196.
5.
YamadaHKimuraKChenD: Effects of daily fat or ethanol ingestion on the cholecystokinin—pancreas and the gastrin—enterochromaffin-like cell axes in rats. Digestion1998; 59: 331–334.
6.
ErikssonCJPMizoiYFukunagaT: The determination of acetaldehyde in human blood by the perchloric acid precipitation method: the characterization and elimination of artefactual acetaldehyde formation. Anal Biochem1982; 125: 159–163.
7.
StadilFRehfeldJF: Determination of gastrin in serum. An evaluation of the reliability of a radioimmunoassay. Scand J Gastroenterol1973; 8: 101–112.
8.
HimenoSTaruiSKanayamaSKuroshimaTShinomuraYHayashiC: Plasma cholecystokinin responses after ingestion of liquid meal and intraduodenal infusion of fat, amino acid, or hydrochloric acid in man: analysis with region specific radioimmunoassay. Am J Gastroenterol1983; 78: 703–707.
9.
CapitaineYSarlesH: Action of ethanol on the sphincter of Oddi in man. Biol Gastroenterol (Paris)1971; 3: 231–236.
10.
ImamuraASasakiITsuchiyaTSatoT: Effects of intragastric ethanol administration on gastric acid secretion and gastrointestinal hormone release in dogs. Tohoku J Exp Med1985; 147: 247–259.
11.
MatsunoKTomitaKOkabeS: Wine stimulates gastric acid secretion in isolated rabbit gastric glands via two different pathways. Aliment Pharmacol Ther2002; 16: 107–114.
12.
NishiwakiHLeeKYCheyWY: Effect of alcohol on plasma secretin concentration and pancreatic secretion in dogs. Surgery1984; 95: 85–89.
13.
SingerMVLeffmannCEysseleinVECaldenHGoebellH: Action of ethanol and some alcoholic beverages on gastric acid secretion and release of gastrin in humans. Gastroenterology1987; 93: 1247–1254.
14.
PetersonWLBarnettCWalshJH: Effect of intragastric infusions of ethanol and wine on serum gastrin concentration and gastric acid secretion. Gastroenterology1986; 91: 1390–1395.
15.
HajnalFFloresMCValenzuelaJE: Effect of alcohol and alcoholic beverages on nonstimulated pancreatic secretion in humans. Pancreas1989; 4: 486–491.
16.
StrausEUrbachHJYalowRS: Alcohol-stimulated secretion of immunoreactive secretin. N Engl J Med1975; 293: 1031–1032.
17.
BeckerHDReederDDThompsonJC: Gastrin release by ethanol in man and in dogs. Ann Surg1974; 179: 906–909.
18.
LiddleRAGoldfineIDWillamsJA: Bioassay of plasma cholecystokinin in rats: effects of food, trypsin inhibitor, and alcohol. Gastroenterology1984; 87: 542–549.
