The effect of synthetic galanin on plasma glucose, insulin and pancreatic glucagon levels in dogs was studied. Infusion of galanin caused a rapid, reversible and dose-dependent reduction in basal insulin level. A maximal increase in blood glucose level accompanying the insulin decrease was observed when galanin was administered at a dose of 4 μg/kg per h. Pancreatic glucagon levels showed little change compared with basal secretion. These results indicate that galanin is involved in the regulation of glucose through control of insulin secretion.
TatemotoKRokaeusAJornvallHMcDonaldTJMuttV: A novel biologically active peptide from porcine intestine. FEBS Lett1983; 164: 124–128.
2.
MelanderTHokfektTRokaeusAFarrenkrugJTatemotoKMuttV: Distribution of galanin-like immunoreactivity in the gastro-intestinal tract of several mammalian species. Cell Tissue Res1985; 239: 253–270.
3.
RokaeusAMelanderTHokfeltTLundbergJMTatemotoKCarlquistM: A galanin-like peptide in the central nervous system and intestine of the rat. Neurosci Lett1984; 47: 161–166.
4.
BishopAEPolakJMBauerFEChristofidesNDCarleiFBloomSR: Occurrence and distribution of a newly discovered peptide, galanin, in the mammalian enteric nervous system. Gut1986; 27: 849–857.
5.
EkbladEHakansonRSundlerFWahlestedtC: Galanin: neuromodulatory and direct contractile effects on smooth muscle preparations. Br J Pharmacol1985; 86: 241–246.
6.
ZiolkowskaATortorellaCHocholATrejterMNussdorferGGMalendowiczLK: Effects of endogenous galanin on the growth of regenerating rat adrenal gland, as investigated by the metaphase-arrest and the PCNA-immunostaining techniques. Biomed Res2001; 22: 211–214.
7.
ManabeTYoshimuraTKiiETanakaYOhshioGTobeT: Galanin-induced hyperglycemia: effect on insulin and glucagon. Endocrine Res1986; 12: 93–98.
8.
KajiyamaFMukaiyamaSWatanabeYOgataMIguchiKMochizukiT: Effect of galanin(15–29)-related peptides on glucose-induced insulin release from the isolated perfused rat pancreas. Biomed Res1999; 20: 345–351.
9.
YajimaHFutakiSFujiiNAkajiKFunakoshiSSakuraiM: Studies on peptides. CXXXIII. Synthesis and biological activity of galanin, a novel porcine intestinal polypeptide. Chem Pharm Bull1986; 34: 528–539.
10.
BrussMLBlackAL: Enzymatic microdetermination of glycogen. Anal Biochem1978; 84: 309–312.
11.
NishinoTKodairaTShinSImanagaKShimaKKumaharaY: Glucagon radioimmunoassay with use of antiserum to glucagon C-terminal fragment. Clin Chem1981; 27: 1690–1697.
12.
McDonaldTJDupreJTatemotoKGreenbergGRRadziukJMuttV: Galanin inhibits insulin secretion and induces hyperglycemia in dogs. Diabetes1985; 34: 192–196.
13.
DunningBEAhrenBVeithRCBottcherGSundlerFTaborskyGJJr: Galanin: a novel pancreatic neuropeptide. Am J Physiol1986; 251: E127–E133.
14.
SherwinRSHendlerRDeFronzoRWahrenJFelicP: Glucose homeostasis during prolonged suppression of glucagon and insulin secretion by somatostatin. Proc Natl Acad Sci U S A1977; 74: 348–352.
15.
AltszulerNGottliebBHampshireJ: Interaction of somatostatin, glucagon, and insulin on hepatic glucose output in the normal dog. Diabetes1976; 25: 116–121.
16.
ChideckelEWPalmerJKoerkerDJEnsinckJDavidsonMBGoodnerCJ: Somatostatin blockade of acute and chronic stimuli of the endocrine pancreas and the consequences of this blockade on glucose homeostasis. J Clin Invest1975; 55: 754–762.
17.
JohnsonDGEnsinckJWKoerkerDPalmerJGoodnerCJ: Inhibition of glucagon and insulin secretion by somatostatin in the rat pancreas in situ. Endocrinology1975; 96: 370–374.
18.
EkbladERokaeusAHakansonRSundlerF: Galanin nerve fibers in the rat: distribution, origin and projections. Neuroscience1985; 16: 355–363.
