Compound 21,the first orally active,selective agonist of the angiotensin type 2 receptor (AT2): implications for AT2 receptor research and therapeutic potential

Steckelings UM , Kaschina E. , Unger T. The AT2 receptor - a matter of love and hate . Peptides 2005;26:1401-09.

Unger T. Björn Folkow award lecture. The angiotensin II receptor: variations on an enigmatic theme. J Hypertens 1999;17:1775-86.

Hein L. , Barsh GS , Pratt RE , Dzau VJ , Kobilka BK Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature 1995;377:744-7.

Ichiki T. , Labosky PA , Shiota C. et al. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature 1995 ;377:748-50.

de Gasparo M. , Catt KJ , Inagami T. , Wright JW , Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 2000;52:415-72.

Jones ES , Vinh A. , McCarthy CA , Gaspari TA , Widdop RE AT2 receptors: functional relevance in cardiovascular disease. Pharmacol Ther 2008;120:292-316.

Funke-Kaiser H. , Reinemund J. , Steckelings UM , Unger T. Signal transduction and regulation of the angiotensin type 2 receptor (AT2) - implications for cardiac pathophysiology . J Renin Angiotensin Aldosterone Syst 2009 ;(In press).

Ichihara S. , Senbonmatsu T. , Price E. Jr , Ichiki T. , Gaffney FA , Inagami T. Targeted deletion of angiotensin type 2 receptor (AT2) caused cardiac rupture after acute myocardial infarction. Circulation 2002;106:2244-9.

Gallinat S. , Busche S. , Schütze S. , Kronke M. , Unger T. AT2 receptor stimulation induces generation of ceramides in PC12W cells. FEBS Lett 1999;443(1):75-9.

Laflamme L. , Gasparo M. , Gallo JM , Payet MD , Gallo-Payet N. Angiotensin II induction of neurite outgrowth by AT2 receptors in NG108-15 cells. Effect counteracted by the AT1 receptors . J Biol Chem 1996;271:22729-35.

Meffert S. , Stoll M. , Steckelings UM , Bottari SP , Unger T. The angiotensin II AT2 receptor inhibits proliferation and promotes differentiation in PC12W cells. Mol Cell Endocrinol 1996;122:59-67.

Lucius R. , Gallinat S. , Rosenstiel P. , Herdegen T. , Sievers J. , Unger T. The angiotensin type 2 receptor (AT2) promotes axonal regeneration in the optic nerve of adult rats. J Exp Med 1998;188:661-70.

Reinecke K. , Lucius R. , Reinecke A. , Rickert U. , Herdegen T. , Unger T. Angiotensin II accelerates functional recovery in the rat sciatic nerve in vivo: role of the AT2 receptor and the transcription factor NF-kappaB. FASEB J 2003;17:2094-6.

Iwai M. , Liu HW , Chen R. et al. Possible inhibition of focal cerebral ischemia by angiotensin type 2 receptor (AT2) stimulation. Circulation 2004;110:843-8.

Li J. , Culman J. , Hörtnagl H. et al. Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury. FASEB J 2005;19:617-19.

Gohlke P. , Pees C. , Unger T. AT2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism. Hypertension 1998;31:349-55.

Siragy HM AT1 and AT2 receptor in the kidney: role in health and disease. Semin Nephrol 2004;24(2):93-100.

Wan Y. , Wallinder C. , Plouffe B. et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem 2004;47:5995-6008.

Kaschina E. , Grzesiak A. , Li J. et al. AT2-receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin-system in myocardial infarction? Circulation 2008;118:2523-32.

Steckelings UM , Rompe F. , Kaschina E. et al. The past, present and future of angiotensin type 2 receptor (AT2) stimulation. J Renin Angiotensin Aldosterone Syst 2009; (In press).