Blaufarb IS, Sonnenblick EHThe renin-angiotensin system in left ventricular remodeling. Am J Cardiol1996;77:8C-16C.
2.
Weir R., McMurray JJTreatments that improve outcome in the patient with heart failure, left ventricular systolic dysfunction, or both after acute myocardial infarction . Heart2005;91(suppl 2):ii17-20.
3.
Campbell DJ, Aggarwal A., Esler M., Kaye D.Beta-blockers, angiotensin II, and ACE inhibitors in patients with heart failure . Lancet2001;358:1609-10.
4.
Francis GS, Benedict C., Johnstone DE et al. Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure. A substudy of the Studies of Left Ventricular Dysfunction (SOLVD). Circulation1990;82:1724-9.
5.
Brewster UC, Setaro JF, Perazella MAThe renin-angiotensin-aldosterone system: cardiorenal effects and implications for renal and cardiovascular disease states. Am J Med Sci2003;326:15-24.
6.
Swedberg K., Eneroth P., Kjekshus J., Wilhelmsen L.Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group . Circulation1990;82:1730-6.
Sakoda M., Ichihara A., Kaneshiro Y. et al. (Pro)renin receptor-mediated activation of mitogen-activated protein kinases in human vascular smooth muscle cells. Hypertens Res2007;30: 1139-46.
9.
de Boer RA, Pokharel S., Flesch M. et al. Extracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27. J Mol Med2004 ;82:678-87.
10.
Dendorfer A. , Dominiak P., Schunkert H.ACE inhibitors and angiotensin II receptor antagonists. Handb Exp Pharmacol2005;170:407-42.
11.
Tang WH, Vagelos RH, Yee YG et al. Neurohormonal and clinical responses to high- versus low-dose enalapril therapy in chronic heart failure. J Am Coll Cardiol2002; 39(1): 70-8.
12.
McMurray JJ , Ostergren J., Swedberg K. et al.; CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. Lancet2003;362:767-71.
13.
Cohn JN, Tognoni G.; Valsartan Heart Failure Trial Investigators.A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure . N Engl J Med2001;345:1667-75.
14.
Pitt B., Zannad F., Remme WJ et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators . N Engl J Med1999;341:709-17.
15.
Lakkis J., Lu WX, Weir MRRAAS escape: a real clinical entity that may be important in the progression of cardiovascular and renal disease. Curr Hypertens Rep2003;5: 408-17.
16.
Feldt S., Batenburg WW, Mazak I. et al. Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertension2008;51:682-8.
17.
Feldman DL, Jin L., Xuan H. et al. Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats. Hypertension2008;52:130-6.
18.
Mento PF, Maita ME, Murphy WR, Holt WF, Wilkes BMComparison of angiotensin converting enzyme and renin inhibition in rats following myocardial infarction. J Cardiovasc Pharmacol1993;21:791-6.
19.
Pilz B., Shagdarsuren E., Wellner M. et al. Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats. Hypertension2005;46: 569-76.
20.
Kiowski W., Beermann J., Rickenbacher P. et al. Angiotensinergic versus nonangiotensinergic hemodynamic effects of converting enzyme inhibition in patients with chronic heart failure. Assessment by acute renin and converting enzyme inhibition. Circulation1994;90:2748-56.
21.
Neuberg GW, Kukin ML, Penn J., Medina N., Yushak M., Packer M.Hemodynamic effects of renin inhibition by enalkiren in chronic congestive heart failure. Am J Cardiol1991;67:63-6.
22.
Waldmeier F. , Glaenzel U., Wirz B. et al. Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers . Drug Metab Dispos2007;35:1418-28.
23.
Seed A., Gardner R., McMurray J. et al. Neurohumoral effects of the new orally active renin inhibitor, aliskiren, in chronic heart failure. Eur J Heart Fail2007;9:1120-7.
24.
McMurray J. , Pitt B., Latini R. et al. Effects of the oral direct inhibitor aliskiren in patients with symptomatic heart failure . Circ Heart Fail2008;1:17-24.
25.
Gardner RS, Ozalp F., Murday AJ, Robb SD, McDonagh TAN-terminal pro-brain natriuretic peptide. A new gold standard in predicting mortality in patients with advanced heart failure. Eur Heart J2003;24:1735-43.
26.
Solomon S. , Appelbaum E., Manning WJ et al. Effect of the direct renin inhibitor aliskiren, either alone or in combination with losartan, compared to losartan, on left ventricular mass in patients with hypertension and left ventricular hypertrophy: the Aliskiren Left Ventricular Assessment of Hypertrophy (ALLAY) Trial. Late Breaker presentation at American College of Cardiology 57th Scientific Sessions, 2008.
27.
ASPIRE HIGHER clinical program expands to 35,000 patients in 14 trials, the largest cardio-renal outcomes program ever. http://www.novartis.com/newsroom/mediareleases/en/2008/1228485.shtml June 17 2008.