Questions & Answers — Understanding the Renin System

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References

Azizi M. , Webb R. , Nussberger J. et al. Renin inhibition with aliskiren: where are we now, and where are we going? J Hypertens 2006;24:243-56.

Nguyen G. , Delarue F. , Burcklé C. et al. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 2002;109:1417-27.

Ichihara A. , Hayashi M. , Kaneshiro Y. et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the `handle' region for nonproteolytic activation of prorenin. J Clin Invest 2004;114:1128-35.

Danser AHJ , van Kesteren CA , Bax WA et al. Prorenin, renin, angiotensinogen, and angiotensin-converting enzyme in normal and failing human hearts. Evidence for renin binding. Circulation 1997;96:220-6.

Deinum J. , Ronn B. , Mathiesen E. et al. Increase in serum prorenin precedes onset of microalbuminuria in patients with insulindependent diabetes mellitus. Diabetologia 1999;42:1006-10.

Chiarelli F. , Pomilio M. , De Luca FA et al. Plasma prorenin levels may predict persistent microalbuminuria in children with diabetes. Pediatr Nephrol 2001;16:116-20.

Deinum J. , Tarnow L. , van Gool JM et al. Plasma renin and prorenin and renin gene variation in patients with insulindependent diabetes mellitus and nephropathy. Nephrol Dial Transplant 1999;14:1904-11.

Daneman D. , Crompton CH , Balfe JW et al. Plasma prorenin as an early marker of nephropathy in diabetic (IDDM) adolescents. Kidney Int 1994;46:1154-9.

Danser AH , van den Dorpel MA , Deinum J. et al. Renin, prorenin, and immunoreactive renin in vitreous fluid from eyes with and without diabetic retinopathy. J Clin Endocrinol Metab 1989; 68:160-7.

10.

Wilson DM , Luetscher JA Plasma prorenin activity and complications in children with insulin-dependent diabetes mellitus. N Engl J Med 1990;323:1101-6.

11.

Yokota H. , Mori F. , Kai K. et al. Serum prorenin levels and diabetic retinopathy in type 2 diabetes: new method to measure serum level of prorenin using antibody activating direct kinetic assay. Br J Ophthalmol 2005;89:871-3.

12.

Singh HJ , Rahman A. , Larmie ET et al. Raised prorenin and renin concentrations in pre-eclamptic placentae when measured after acid activation. Placenta 2004;25:631-6.

13.

Vrtacnik-Bokal E. , Meden-Vrtovec H. , Osredkar J. et al. Follicular fluid renin concentration in patients with polycystic ovaries treated with gonadotrophins in an in vitro fertilisation programme. Clin Chem Lab Med 2003;41:663-7.

14.

Giles TD , Berk BC , Black HR et al. Expanding the definition and classification of hypertension . J Clin Hypertens 2005;7:505-12.

15.

Ichihara A. , Kaneshiro Y. , Takemitsu T. et al. Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension 2006;47:894-900.

16.

Satofuka S. , Ichihara A. , Nagai N. et al. Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin . Invest Ophthalmol Vis Sci 2006;47:2686-92.

17.

Feldt S. , Batenburg WW , Mazak I. et al. Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertension 2008;51:682-8.

18.

Feldt S. , Maschke U. , Dechend R. et al. The putative (pro)renin receptor blocker HRP fails to prevent (pro)renin signaling. J Am Soc Nephrol 2008 ; 19:743-8.

19.

Burcklé CA , Jan Danser AH , Muller DN et al. Elevated blood pressure and heart rate in human renin receptor transgenic rats. Hypertension 2006;47:552-6.

20.

Kaneshiro Y. , Ichihara A. , Sakoda M. et al. Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats. J Am Soc Nephrol 2007;18:1789-95.

21.

Stankovic AR , Fisher ND , Hollenberg NK Prorenin and angiotensin-dependent renal vasoconstriction in type 1 and type 2 diabetes. J Am Soc Nephrol 2006;17:3293-9.

22.

Kang JJ , Toma I. , Sipos A. et al. The collecting duct is the major source of prorenin in diabetes . Hypertension 2008;51:1597-604.

23.

Siragy HM Renin inhibition: a new modality for hypertension management. Curr Hypertens Rep 2007;9:291-4.

24.

Price DA , Porter LE , Gordon M. et al. The paradox of the low-renin state in diabetic nephropathy. J Am Soc Nephrol 1999; 10:2382-91.