Suzuki F., Hayakawa M., Nakagawa T. et al. Human prorenin has `gate and handle` regions for its non-proteolytic activation. J Biol Chem2003;278:22217-22.
2.
Nabi Ahmn, Kageshima A., Uddin M. et al. Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system. Int J Mol Med2006;18:483-8.
3.
Nabi Ahmn, Uddin M., Nakagawa T. et al. Role of `handle` region of prorenin prosegment in the nonproteolytic activation of prorenin by binding to membrane anchored (pro)renin receptor . Front Biosci2007;12:4810-17.
4.
Batenburg WW , Krop MK, Garrelds IM et al. Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor . J Hypertens2007;25:2441-53. 5. Feldt S., Batenburg WW, Mazak I. et al. Prorenin and renin-induced extracellular signal regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertension2008;51:published online Jan 22.
5.
Ichihara A., Hayashi M., Kaneshiro Y. et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the `handle` region for non-proteolytic activation of prorenin. J Clin Invest2004;114:1128-35.
6.
Takahashi H. , Ichihara A., Kaneshiro Y. et al. Regression of nephropathy developed in diabetes by (pro)renin receptor blockade. J Am Soc Nephrol2007;18:2054-61.