This paper used the standardized criteria proposed by Aylward et al I995 for diagnosing Alzheimer's Disease in individuals with learning disabilities to undertake a prospective, longitudinal study of 22 individuals with Down's syndrome. Results show that, after a period of up to 6 years, four individuals showed functional decline. A similar pattern of decline was found to that described in previous studies, although the mean age of onset was later. All four subjects met the criteria for probable Alzheimer's Disease.
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