PEPTIDE-NUCLEIC acid solution* which had previously been reported to show in vivo efficacy in several viral infections (i.e. influenza, hepati tis, mumps, encephalitis, etc) was tested in three independent laboratories, including the US National Institutes of Health by specific in vitro methods for HIV and Influenza A. The results of these studies demonstrated significant anti-viral activity of the peptide-nucleic acid solution against the Human Immunodeficiency Virus (HIV) and the Influenza A virus.
Get full access to this article
View all access options for this article.
References
1.
Anderson, R.N., Wilkins, W.B. and Thompson, R.M. (1957) Treatment of viral diseases with a lipoprotein nucleic acid complex (reticulose), A clinical study; Scientific Exhibit, Virginia Medical Society Meeting, Washington DC.
2.
Anderson, R.H. and Thompson, R.M. (1957) Treatment of viral syndromes with a lipoprotein-nucleic acid compound (reticulose). Virginia Medical Monthly, 84: 347-353.
3.
Anderson, R.H. (1960) Encephalitis; Clinical symposium on viral diseases demonstrating antiviral properties of the drug reticulose, 39-52; Miami Beach, Florida.
4.
Buck, H.M., Koole, L.H., Van Genderen, M.H.P., Smit, L., Geelen, J.L.M.C., Jurriaans, and Goudsmit, J. (1990) Phosphate methylated DNA aimed at HIV-1 RNA loops and integrated DNA inhibits viral infectivity: Science, 248: 208-212.
5.
Bus$o, M., Mian, A.M., Hahn, E.F. and Resnick, L. (1988) Nucleotide dimers supress HIV expression in vitro . Aids Research and Human Retroviruses, 4: 449-455.
6.
Goodchild, J.S., Agrawal, S., Civeira, M.P., Sarin, P.S., Sun, D. and Zamecnik, P.C. (1988) Inhibition of human immunodeficiency virus replication by antisense oligonucleotides. Proc. Natl. Acad. Sci. USA , 85: 5507-5511.
7.
Kosaka, K., Shimada, Y. (1960) Infectious hepatitis; clinical symposium on viral diseases demonstrating antiviral properties of the drug reticulose, 61-74; Miami Beach, Florida .
8.
Lifson, J.D., Hwang, K.M., Nara, P.L., Fraser, B., Padgett, M., Dunlop, N.M. and Eiden, L.E. (1988) Synthetic CD4 peptide derivatives that inhabit HIV infection and cytopathicity. Science, 241: 712-716.
9.
Michael, N.L., Morrow, P., Mosca, J., Vahey, M.A., Burke, D.S. and Redfield, R.R. (1988) Induction of human immunodeficiency virus Type 1 expression in chronically infected cells is associated primarily with a shift in RNA splicing patterns. J. Virol, 65: 1291-1303.
10.
Pert, C.B., Hill, J.M.Ruff, M.R., Berman, R.M., Robey, W.G., Arthur, L.O., Ruscetti, F.W. and Farrar, W.L. (1986) Octapeptides deduced from the neuropeptide receptor-like pattern of antigen T4 in brain potently inhibit human immunodeficiency virus receptorbinding and T-cell infectivity. Proc. Natl. Acad. Sci. USA, 83: 92549258.
11.
Popovic, M., Sarngadharan, M.G., Read, E. and Gallo, R.C. (1984) Detection, isolation and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS . Science, 224:497-500.
12.
Schaeffer, O. and Sydel, F. JR., (1960) Influenza; Clinical symposium on viral diseases demonstrating antiviral properties of the drug reticulose, 15-24; Miami Beach, Florida.
13.
Stevenson, M. and Iverson, P.L. (1989) Inhibition of human immunodeficiency virus Type 1-mediated cytopathic effects by poly (L-lysine)-conjugated synthetic antisense oligodeoxy-nucleotides. J. Gen. Virol., 70: 2673-2682.
14.
Sczakiel, G. and Pawlita, M. (1991) Inhibition of human immunodeficiency virus Type 1 replication in human T cells stably expressing antisense RNA. Jour. of Virology, 65: 468-472.
15.
To, Y.Y.Booth, S.C. and Nieman, P. (1986) Inhibition of retroviral replication by antisense RNA. Mol. Cell. Biol., 6: 4758-4762.
16.
Toxicity Reports, Huntingdon Research Centre, Baltimore, Maryland, USA. (1969) Personal Communication.
17.
Toxity Reports, International Diagnostics Ltd, Dania, Florida, USA. (1989) Personal Communication.
18.
Zamecnik, P.C., Goodchild, J.S., Taguchi, Y. and Sarin, P.S. (1986) Inhibition of replication and expression of human T-cell lymphotropic virus Type III in cultured cells by exogenous synthetic oligonucleotides complementary to rival RNA. Proc. Natl. Acad. Sci. USA, 75: 280-284.
