Campbell, S., Smith, P. & Pearce, J.M. (1984). The ultrasound diagnosis of neural tube defects and other cranio-spinal abnormalities in 'prenatal diagnosis' Eds. Rodeck, C. H. & Nicolaides, K. H. Roy. Col. of Obs. & Gynae., London245-257.
8.
Carter, C.O. (1974). Clues to the aetiology of neural tube malformationsDev. Med. Child Neurol. 16. Supplement 34, 3-15.
9.
Carter, C.O., R Oberts, J.F., Evans, K. & Bude, A.R. (1971). Genetic Clinic: A follow upLanceti, 281-285.
10.
Crawfurd, M. D'A., Meire, H.G. & F Arrant, P. (1981) Screening for abnormalities by ultrasoundJ. of Med. Genet. 18 , 220-221.
11.
Edwards, J.H. (1982). Vitamin supplementation and neural tube defectsLancet, i , 275-276.
12.
ELDER, G. ( 1985). Personal communication.
13.
Elmes, M.E. ( 1983). Zinc absorption and metabolism In Dodge, J. A. (Ed.) 'Paediatric Nutrition'Tunbridge Wells: Pitmans Medical publications, 170-179.
14.
Elwood, J.M. & Elwood, J.H. (1980). 'Epidemiology of anencephaly and spina bifida' P. 23. Oxford University Press, Oxford.
15.
Fearn, J., Hibbard, B.M., Laurence, K.M., Roberts, A. & Robinson, J.O. (1982). Screening for neural tube defects and maternal anxiety. Brit. J. Obstet. Gynaecol.89: 218-221.
16.
Hibbard, B.M., Roberts, C.J., Elder, G.H., Evans, K.T. & Laurence, K.M. (1985). Neural tube defects screening, can we afford it? The South Wales ExperienceBrit. J. Med, 290: 293-295.
17.
Hibbard, B.M., Roberts, C.J., Evans, K.T., Laurence, K.M., & Hoole, G. (1980). Antenatal attendance and screening for neural tube defects.Brit. J. Obstet. Gynaecol. , 97: 10-18.
18.
Hibbard, E.D. & Smithells, R.W. (1965). Folic acid metabolism and human embryopathyLancet, i, 1254.
19.
James, N., Laurence, K.M. & Miller, M. (1980). Diet as a factor in the aetiology of neural tube malformations. Z. Kinderch, 31, 302-7.
20.
Lancet (1985). Vitamin A and teratogenesis. Lancet, i, 319-320.
21.
Lancet(1985). Prevention of neural defects: Medical Research Council Vitamin StudyLancet , i, 535.
22.
Laurence, K.M. & Morris, J. ( 1981 ). The effect of introduction of parental diagnosis on the reproductive history of women at increased risk from neural tube defectsPrenatal Diagnosis, 1, 51-60.
Laurence, K.M. (1982). Neural tube defects: a two-pronged approach to preventionPaediatrics, 70, 648-650.
25.
Laurence, K.M. (1983). Genetics and prevention of neural tube defects In Principles and Practices of Medical Genetics (Eds.) Emery, A. E. H. & Rimoin, D. L. Edinburgh: Churchill Livingstone, Vol. 1, 232-245.
26.
Laurence, K.M. (1985). Prevalence of neural tube defect in two countries in South Wales over three decades illustrating the need for continued action and vigilanceZ. Kinderchir. (in press).
27.
Laurence, K.M. & Campbell, H. ( 1981 ). Trial of folate treatment to prevent recurrence of neural tube defectBr. Med. J., 282, 2131.
28.
Laurence, K.M., Carter, C.O. & David, P.A. (1968). The major central nervous system malformations in South Wales I. Incidence local variations and geogrphical factors. Brit. J. Prev. Soc. Med., 22: 146-160.
29.
Laurence, K.M., Carter, C.O. & David, P.A. (1968). The major central nervous system malformations in South Wales II. Pregnancy factors, seasonal variations and social class effectsBr. J. Prev. Soc. Med., 22, 212-222.
30.
Laurence, K.M.Dew, J.O., Dyer, C. & Downey, K.H. (1983). Amniocentesis carried out for neural tube indicationsPrenatal Diagnosis, 3: 187-201.
31.
Laurence, K.M., Hibbard, B.M., E Lder, G., Hoole, G., Evans, K.T. & Roberts, C.J. (1985). Should women at high risk for neural tube defect have an amniocentesis?J. Med. Genet., 22, 457-461.
32.
Laurence, K.M., James, N. & Campbell, H. ( 1982). Blood folate levels and quality of the maternal dietBr. Med. J., 285, 216.
33.
Laurence, K.M., James, N., Campbell, H. (1983). The role of improvement in the maternal diet and preconceptional folic acid supplementation in the prevention of neural tube defects in "Prevention of spina bifida and other neural tube defects" Ed. Dobbing, J., Academic Press, London, 85-125.
34.
Laurence, K.M., James, N., Miller, M. & Campbell, H. (1980). Increased risk of recurrence of neural tube defects to mothers on poor diets and the possible benefits of dietary counsellingBr. Med. J., 281, 1542-1544.
35.
Laurence, K.M., James, N., Miller, M., Tennant, G.P. & Campbell, H. (1981). Double-blind randomised controlled trial of folate treatment before conception to prevent recurrences of neural tube defectsBr. Med. J., 282, 1509-1511.
36.
Lorber, J. (1982). Vitamins to prevent neural tube defectsLancet, ii, 1458-1459.
37.
Morris, J. & Laurence, K.M. (1976). The effectiveness of genetic counselling for neural tube malformationsDevelop. Med. Child. Neurol., 18: Suppl. 37, 157-163.
Nevin, N.C. (1981). Neural tube defects. Lancet , ii, 1290-1291.
40.
Record, R.G. & Mckeown, T. ( 1949). Congenital malformations of the central nervous system in a surrey of 930 casesBr. J. Prev. Soc. Med., 3, 183-219.
41.
Richards, I.D.G. ( 1971 ). The incidence of congenital defects in South Wales. Ph.D Thesis, University of Wales.
42.
Roberts, C.J., Evans, K.T., Hibbard, B.M., Laurence, K.M., Roberts, E.E. & Robertson, I.B. ( 1983). Diagnostic effectiveness of ultrasound in the detection of neural tube defects: the South Wales experience of 2509 high risk pregnancies (1977-1982)Lancet , ii: 1068-9.
43.
Roberts, C.J., Evans, D., Hoole, G., Roberts, E., Ennis, W.P., Evans, K.T., Hibbard, B.M. and Laurence, K.M. ( 1979). Precision in
44.
the estimation of gestational age and its influence in the sensitivity of AFP screening for neural tube defectsBrit. Med. J. , 2: 981-1318.
45.
Robinson, J.O., Hibbard, B.M. & Laurence, K.M. (1984). Anxiety during a crisis; emotional effects of screening for neural tube defectsPsychosomatic Ped., 26: 163-169.
46.
Seller, M.J. (1981). Recurrence risks for neural tube defects in a genetic counselling populationJ. Med. Genet. , 18, 245-248.
47.
Seller, M.J. (1982). Nutritional supplementation and prevention of neural tube defects. In 'Clinical Genetics: problems in diagnosis and counselling' (A. M. Willey, T. P. Carter, S. Kelly & I. H. Parker, eds). Academic Press, London and New York P1.
48.
Seller, M.J., Hancock, P.C. (1985). Is recurrence rate of neural tube defects declining?Lancet, i . 175.
49.
Shepard, T.H., Tanimura, T. & Robkin, M.A. (1970). Energy metabolism in early mammalian embryosDev. Biol. Suppl., 4, 42-58.
Smith, A.D., Wald, N.J., Cuckle, H.S. ,Starrat, G.M., Bobrow, M. & Langerorantz, H. (1979). Amniotic fluid acetylcholinesterase as a possible diagnostic test for neural tube defects in early pregnancyLancet, i , 665-668
52.
Smithells, R.W. (1983). Prevention of neural tube defects by vitamin supplements in 'Prevention ofspina bifida and other neural tube defects' Ed. Dobbing J. Academic Press, London53-84.
53.
Smithells, R.W., Ankers, C., Carver, M.E., Lennon, D., Schorah, C.J. & Sheppard, S. (1977). Maternal nutrition in early pregnancy. Br. J. Nutr., 38 , 497-506.
54.
Smithells, R.W., Nevin, N.C., Seller, M.J., et al (1983). Further experience with vitamin supplementation for prevention of neural tube defect recurrencesLancet , i, 1027-1031.
55.
Smithells, R.W., Sheppard, S. & Schorah, C.J. (1976). Nutritional deficiencies and neural tube defectsArch. Dis. Child., 51, 944-50.
56.
Smithells, R.W., Sheppard, S., Schorah, C.J., Nevin, N.C. & Seller, M.J. (1981). Trial of folate therapy to prevent recurrences of neural tube defectsBr. Med. J., 282, 1793.
57.
Smithells, R.W.,Sheppard,Schorah, C.J.,Seller, M.J.,Nevin, N.C.,Harris, R., Read, A.P. & Fielding, D.W. (1980). Possible prevention of neural tube defects by periconceptional vitamin supplementationLancet, i, 339-340.
58.
Smithells, R.W., S Hlppard, S., S Chorah, C.J., S Eller, M.J., N Evin, N.C., Harris, R., Read, A.P. & Fielding, D.W. (1981). Apparent prevention of neural tube defects by periconceptional vitamin supplementation. Arch. Dis. Child., 56, 911-918.
59.
Smithells, R.W., Sheppard, S., Schorah, C.J., Seller, M.J., Nevin, N.C., Harris, R., Read, A.P., Fielding, D.W. & Walker, S. (1981). Vitamin supplementation and neural tube defects. Lancet, ii, 1424-1425. STONE, D. H. (1980). Possible prevention of neural tube defects by periconceptional vitamin supplementationLancet, i, 647.
60.
Tamura, T., Shane, B., Boer, M.T., King, J.C., Morgan, S., Stockstad, E.L.R. (1978). Absorption of mono- and poly- glutamyl folates in zinc depleted manAm. J. Clin. Nutr. , 31, 1984-1987.
61.
Tanimura, T. & Shepard, T.H. (1970). Glucose metabolism by rat embryos, in Vitro. Proc. Soc. Ex Biol. Med., 135, 51-54.
62.
Thiersch, J.B. (1952). Therapeutic abortions with folic acid antagonist, 4 amino pteroylglutamic acid (4 amino PGA) administered by oral routeAm. J. Obstet. Gynaecol., 63 , 1298-1304.
63.
UK collaborative study ( 1979). Second report of the UK collaborative study on alphafetoprotein in relation to neural tube defects. Alphafetoprotein measurement in the diagnosis of anencephaly and open spina bifida in early pregnancyLancet, ii, 651-662.
64.
UK collaborative study (1977). Maternal serum alphafetoprotein measurement in the antenatal screening for anencephaly and spina bifida in early pregnancyLancet , i, 1323-1332.
65.
Wald, N. (1983). Possible prevention of neural tube defects by vitamin supplementation in 'Prevention of spina bifida and other neural tube defects' Ed. Dobbing, J. Academic Press, London. 231-239.
66.
Wald, N.J. & Cuckle, H.S. ( 1980). Alphafetoprotein in the antenatal diagnosis of open neural tube defects.Brit, J., Hosp. Med. , 473-489.
67.
Wald, N.J. & Polani, P.E. (1984). Neural tube defects and vitamins: the need for a randomised clinical trialBrit, J., Obstet. Gynaecol. , 19, 516-523.