This paper examines whether or not there is a problem for information systems evaluation in healthcare, given the contrast between the quantitative and qualitative research approaches. Experience gained on two systematic reviews on health information systems conducted under the auspices of EPOC (Cochrane Effective Practice and Organization of Care Group) demonstrates that searching strategies need to take account of the way technology is adapted, and accepted, with accompanying changes in terminology. One review concerned nursing record systems, the other telemedicine. Various frameworks for information systems evaluation emphasize the importance of a holistic view of evaluation, an apparent contrast to the evidence-based medicine model based on the randomized controlled trial (RCT). While RCTs are possible and desirable in health-care information systems evaluation, the equivocal results obtained from the reviews suggest that a pluralistic approach is highly desirable.