The understanding of acute and chronic wound pathophysiology has progressed considerably over the past decades. Unfortunately, improvement in clinical practice has not followed suit, although new trends and developments have improved the outcome of wound treatment in many ways. This review focuses on promising clinical development in major wound problems in general and on postoperative infections in particular.
GottrupF: A specialized wound-healing center concepts: Importance of a multidisciplinary department structure and surgical treatment fascilities in the treatment of chronic wounds. Am J Surg2004;187 (Suppl May 2004):38S–43S.
4.
International Working Group on the Diabetic Foot. International Consensus on the Diabeteic Foot. Maastricht. 1999.
5.
GranickMSMcGowanELongCD: Outcome assessment of an in-hospital cross-functional wound care teamPlast Reconstr Surg101(5):1243, 1998.
6.
LongCGranickM: A multidisciplinary approach to wound care in the hospitalized patientClin Plast Surg25(3):425, 1998.
7.
GottrupF: Wound healing and principles of wound closure. In: Scandinavian Plastic SurgeryKuokkanenHHolmstömHÅbyholmF.E.DrzewieckiK.T.Studenterlitteratur A B, Lund, Sweden, 2008, pp. 31–58.
8.
BanwellPETeotL: Topical negative pressure (TNP): The evaluation of a novel wound therapy. J Wound Care2003;12:1–7.
9.
Gallant-BehmCLYinHQLiuSHeggersJPLangfordREOlsonMEHartDABurrellRE: Comparison of in vitro disc diffusion and time kill-kinetic assays for the evaluation of antimicrobial wound dressing efficacy. Wound Repair and Reg2005;13:412–421.
10.
MooreKGrayD: Using PHMB antimicrobial to prevent wound infection. Wounds UK2007;3:96–102.
11.
JørgensenBFriisGJGottrupF: Pain and quality of life for patients with venous leg ulcers: Proof of concept of the efficacy of Biatain-Ibu, a new pain reducing wound dressing. Wound Repair Regen2006;14:233–239.
12.
GottrupFJørgensenBKarlsmarkTSibbaldRGRimdeikaRHardingKPricePVenningVVowdenPJüngerMWortmannSSulcaiteRVilkeviciusGAhokasT-LEttlerKArenbergerovaM: Reducing wound pain in venous leg ulcers with Biatain — Ibu: A randomized-controlled double-blind clinical investigation on the performance and safety. Wound Repair Regen. 2008;16:616–626.
13.
WollinaU: Major developments in wound care: A critical appraisal. Int J Low Extrem Wounds. 2008;7:6–8.
14.
GottrupFHolsteinPJørgensenBLohmannMKarlsmarkT: A new concept of a multidisciplinary wound healing center and a national expert function of wound healing. Arch Surg. 2001;136:765–772.
15.
GottrupF: Optimizing wound treatment through health care structuring and professional education. Wound Rep Reg2004;12:129–133.
16.
GottrupF: A specialised wound healing center concept: Importance of a multidisciplinary department structure and surgical treatment facilities in the treatment of chronic wounds. Am J Surg2004;187:38–43S.
17.
GottrupF: Management of the Diabetic Foot: Surgical and Organisational Aspects. Horm Metab Res2005;37, Supplement 1:69–75.
18.
KjaerMLSorensenLTKarlsmarkTMainzJGottrupFEvaluation of the quality of venous leg ulcer care given in a multidisciplinary specialist centre. J Wound Care2005;14:145–150.
19.
SackettDLRosenbergWMCGrayJAMHaynesRBRichardsonWS: Evidence-based medicine: What is and what isn't. BMJ1996:312:71–72.
20.
BouzaCMunozAAmataJM: Efficacy of modern dressings in the treatment of leg ulcers: A systematic review. Wound Rep Reg2005;13:218–229.
21.
PalfreymanSNelsonEAMichaelsJA: Dressings for venous leg ulcers: Systematic review and meta-analysis. BMJ2007;335:244.
22.
VaneauMChabyGGuillotBMartelPSenetPTeotLChosidowO: Consensus panel recommendations for chronic and acute wound dressing. Arch Dermatol2007;143:1291–1294.
23.
ChabyGSenetPVeneauM: Dressings for acute and chronic wounds. A systematic review. Arch Dermatol2007;143:1297–1304.
24.
PalfreymanSNelsonEAMichaelsJA: Dressings for venous leg ulcers: Systematic review and meta-analysis. BMJ2007;335:244.
25.
GottrupF: Evidence controversy in wound management. BMJ Rapid Response2008;March 3rd.
26.
GottrupF: Evidence is a challenge in wound management. Editorial. Lower Extremity Wounds. 2006;5:74–65.
27.
SackettDLRosenbergWMCGrayJAMHaynesRBRichardsonWS: Evidence-based medicine: What is and what isn't. BMJ1996:312:71–72.
28.
GottrupF: Education and organization in wound healing and care. In: ShuklaVKManiRTeotLPradhanSManagement of wound healing. Jaypee, New Delhi2007:241–256.
29.
PatelNPGranickMSKanakarisNKGiannoudisPVWerdinFRennekampffH-O: Comparison of wound educations in medial schools in the United states, United Kingdom and Germany. Eplasty2008;8:e8.
30.
EnnisWJValdesWMenedesP: Wound care specialization; A proposal for a comprehensive fellowship program. Wound Rep Reg12:120–128, 2004.
31.
HaleyRWCulverDHMorganWMIdentifying patients at high risk of surgical wound infection. Am J Epidemiol1985;121:206–215.
32.
GottrupF: Prevention of surgical wound infections. Editorial. N Engl J Med2000;342:202–203.
33.
CrusePJEFordR: The epidemiology of wound infections. A 10 year prospective study of 62 939 wounds. Surg Clin North Am1980;60:27–40.
34.
CrusePJE: Clasification of operations and audit of infection. In. Infection in surgical practice. Oxford University Press, Oxford, 1992:1–7.
35.
CulverDHHoranTCGaynesRP: Surgical wound infection rates by wound class, operative procedure, and patient risk index. Am J Med1991;91 (Suppl 3B):152–157.
36.
GottrupF: Oxygen in wound healing and infection. World J Surg2004;28:312–315.
37.
YangGPLongaker: Abstinence from Smoking reduces incisional infection: A randomised controlled trial (Editorial). Ann Surg2003;238:6–8.
38.
SørensenL.T.JørgensenL.N.GottrupF: Biochemical aspects of abdominal wall hernia formation and recurrance. In: Nyhus and Condon's HERNIA (FitzgibbonsR.J.Jr.GreenburgA.G.) Lippincott Williams & Wilkins, Philadelphia, 9–16, 2002.
JørgensenLNKallehaveFChristensenESianaJEGottrupF: Less collagen production in smokers. Surgery1998;123:450–455.
41.
SørensenLTKarlsmarkTGottrupF: Abstinence from smoking reduces incisional wound infection: A randomised controlled trial. Ann Surg2003;238:1–5.
42.
MollerAMVillebroNPedersenT: Effect of preoperative smoking intervention on postoperative complications: A randomised clinical trial. Lancet. 2002;359:114–117.
RosenbergJ: Late postoperative hypoxaemia. Mechanisms and clinical implications. These. Dan Med Bull1995;42:40–46.
45.
GreifRAkçaOHornE-P: Supplementary perioperative oxygen to reduce surgical wound infections. N Engl J Med2000;342:161–167.
46.
BeldaFJAnguileraLAsuncionJG: Supplemntal perioperative oxygen and the risk of surgical wound infection. A randomized controlled trial. JAMA2005;294:2035–2042.
47.
PryorKOFahneyTJLienCA: Surgical site infection and the routine use of perioperative hyperoxia in a general surgical population. A randomized controlled trial. JAMA2004;291:79–87.
48.
GillespieWJWalenkampG: Antibiotic prophylaxis for surgery for proximal femoral and other closed long bone fractures. Cochrane Database Syst rev2000;2:CD000244.
49.
GosselinRARobertsIGillespieWJ: Antibiotics for preventing infection in open limb fracturesCochrane Database Syst Rev2004;1:CD003764.
50.
AndersenBRKallehaveFLAndersenHK: Antibiotics versus placebo for prevention of postoperative infection after appendicectomy. Cochrane Database Syst Rev2005;3:CD001439.
51.
SongFGlennyAM: Antimicrobila prophylaxis on mcolorectal surgery: A systemic review of randomised controlled trials. Health Technol Assess1998;2:1–110.
52.
VerschuurHPDe WeverWWvan BantemPP: Antibiotic prophylaxis in clean and clean-contaminated ear surgery. Cochrane Database Syst Rev2004;3:CD003996.
53.
Sanchez-ManuelFJSeco-GilJL: Antibiotic prophylaxis for hernia repair. Cochrane Database Syst Rev2007;3:CD003769.
54.
WeberWPMartiWRZwahlenMThe timing of surgical antimicrobial prophylaxis. Ann Surg2008;247:918–926.
55.
DellingerEPGrossPABarrettTL: Quality standard for antimicrobial prophylaxis in surgical procedures. Infect Control Hosp1994;15:182–188.
56.
GareyKWDaoTChenH: Timing of vancomycin prophylaxis for cardiac surgery patients and the risk of surgical site infections. J Antimicrob Chem2006;58:645–65.
57.
TannerJWoodingDMoncasterK: Preoperative hair removal to reduce surgical site infection. Cochrane Database Syst Rev2006;3:CD004122.
58.
WebsterJOsborneS: Preoperative bathing or showering with skin antiseptics to prevent surgical site infection. Cochrane Database Syst Rev2006;2:CD004985.
59.
BlockSS: Disinfection, sterilisation and preservation5th ed.Philadelphia: Lippincott Williams & Wilkins Desktop Division2001:159–184, 229–254, 321–336.
60.
EdwardsPSLippAHolmesA: Preoperative skin antiseptics for preventing surgical wound infections after clean surgery. Cochrane Database Syst Rev2004;3:CD00394.
61.
GottrupFJørgensenPHBeckhøj: Sårinfektioner, præ- per- og postoperativ infektionsforebyggelse. Ugeskr Laeger2007;169:4150–4155.
EdlichRFRodeheaverGThackerJGEdgertonMT: Technical factors in wound management. I: HuntTKDunphyJE (Eds) Fundamentals of wound management. Appleton-Century-Crofts, New York. 1979:364–454.
64.
FranchiMGhezziFBenedetti-PaniciPLMelpignanoMFalloLTateoSMaggiRScambiaGMangiliGButtarelli: A multicentre collaborative study on the use of cold scalpel and electrocautery for midline abdominal incision. Am J Surg2001;181:128–132.
65.
KearnsSRConnellyEMMcNallySMcNamaraDADeasyJ: Randomized clinical trial of diathermy versus scalpel incision in elective midline laparotomy. Br J Surg2001;88:41–44.
66.
ChrysosEAthanasakisEAntonakakisSXynosEZorasO: A prospective study comparing diathermy and scalpel incisions in tension-free inguinal hernioplasty. Am J Surg2005;71:326–329.
67.
NilssonT: The relative rate of wound healing in longitudinal and transversal laparotomy incisions. Acta Chir Scand1981;147:503–507.
68.
GrantcharovTRosenbergJ: Vertical compared to transverse incision in abdominal surgery. Eur J Surg2001;167:260–267.
69.
LewisSJEggerMSylvesterPA: Early enteral feeding versus “nil by mouth” after gastrointestinal surgery: Systematic review and meta-analysis of controlled trials. BMJ2001;323:773–77.
70.
AndersenHKLewisSJThomasS: Early enteral nutrition within 24h of colorectal surgery versus later commencement of feeding for postoperative complications. Cochrane Database Syst Rev2006;18:CD00408.
71.
SighVABarbulA: Bacterial biofilms in wounds (Editorial). Wound Repair Regen2008;16:1.
72.
GarthAJSwoggerEWolcottRPulciniELSecorPSestriceJCostertonJWStewartPS: Biofilms in chronic wounds. Wound Repair Regen2008;16:37–44.