Exhaled aerosols can be suspended in the air for long periods, facilitating the transmission of highly infectious respiratory diseases. The risk of exposure to occupants varies due to different usage conditions and driving scenarios of moving vehicles. Therefore, the present study investigates the airborne transmission of contaminants generated by coughing in a moving vehicle and explores the relationship between aerosol dispersion and fluid exchange between the interior and exterior domains of the car under the influence of window opening configurations, seating layouts and driving speeds. The results show that the cross-opening configurations provide a superior contaminant removal efficiency. The effect of seating layout on removal efficiency is significant, although it has a slight effect on air change rate (ACH). The best removal efficiency can be obtained when the passenger sits in the front seat with the right front window opening. Furthermore, the in-cabin ACH is almost linearly correlated with the driving speed. Higher speeds reduce contaminant concentrations faster. However, the risk of driver exposure does not depend solely on ACH, the peak cumulative contaminant concentration and residence time also need to be considered. This study offers data for the prevention and control of respiratory infectious diseases.
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