Respiratory diseases are common infectious illnesses on cruise ships. This study integrated an individual-to-individual probability model, a susceptible-exposed-infected-recovered epidemic model at the individual scale, and an onboard indoor social contact network model for evaluating the infection risk on a typical cruise ship voyage. The integrated model was validated by data from a previous influenza outbreak and was able to simulate the infection spreading. The model was used to assess the effects of various intervention measures on controlling influenza on a cruise ship with one index passenger. The results show that individuals in crew cabins and restaurants faced the highest infection risk. Increasing the air change rate in some or all locations could reduce the infection risk to some extent. High-efficiency particulate air filters and ultraviolet germicidal irradiation devices in ventilation systems were the most effective measures. Surgical masks worn by crew members or a quarantine of the index passenger and his/her roommate could reduce the attack rate only to a moderate extent.
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