This analysis of parental/household smoking (a surro gate for environmental tobacco smoke, ETS) and respira tory symptoms and disease in children updates an ear lier analysis. Some 94 studies of preschool children and 152 studies of school-age or older children published between 1969 and 1998 were examined. Both analyses have shown an age dependency in the relationship between parental/household smoking and respiratory symptoms and disease in children. A statistically signifi cant, though moderate, relationship between parental/ household smoking and respiratory illness was ob served in most (86%) of the studies in preschool chil dren. While almost two thirds (98 of 152) of the studies of school-age children showed a statistically significant re lationship between parental/household smoking and re spiratory symptoms and disease, there was a general lack of consistency of statistical association for specific respiratory endpoints (e.g., asthma, wheeze, bronchitis,
Hood RD, Wu JM, Witorsch RJ, Witorsch P.: Environmental tobacco smoke exposure and respiratory health in children: An updated critical review and analysis of the epidemiological literature. Indoor Environ1992;1:19-35.
2.
Witorsch RJ, Wu JM, Hood RD, Witorsch P.: Further analyses of the role of confounding variables in epidemiologic studies of ETS and the respiratory system of school-age children; in Reverente Jun BR, Weetman DF, Wongphanich M (eds): Proc Int Symp on Indoor Air Quality in Asia. Rothenfluh, Indoor Air International, The International Association for Indoor Air Quality, 1993, pp 313-360.
3.
Witorsch P., Witorsch RJ: Analysis of potential confounding variables in epidemiologic studies of parental/household smoking and respiratory health in pre-school children. Indoor Environ1993;2:71-91.
4.
Cruz JR, Pareja G., de Fernandez A., Peralta F., Caceres P., Cano F.: Epidemiology of acute respiratory tract infections among Guatemalan ambulatory pre-school children. Rev Infect Dis1990;12 (supp) 8):S1029-S1034.
5.
Palmieri M., Longobardi G., Napolitano G., Simonetti Dml: Parental smoking and asthma in childhood. Eur J Pediatr1990 ;149:738-740.
6.
Woodward A., Douglas RM, Graham Nmh, Miles H.: Acute respiratory illness in Adelaide children: Breast feeding modifies the effect of passive smoking. J Epidemiol Community Health1990;44:224-230.
7.
Berg AT, Shapiro ED, Capobianco LA: Group day care and the risk of serious infectious illnesses. Am J Epidemiol1991;133:154-163.
Poder G., Borzsonyi L., Mezei G., Kelemen J.: Effect of parental smoking on wheezy bronchitis and bronchial hyperactivity . Acta Paediatr Hung1991;31:103-113.
10.
Wright AL, Holberg C., Martinez FD, Taussig LM: Relationship of parental smoking to wheezing and non-wheezing lower respiratory tract illnesses in infancy. J Pediatr1991 ;118: 207-214.
11.
Arshad SH, Hide DW: Effect of environmental factors on the development of allergic disorders in infancy. J Allergy Clin Immunol1992;90: 235-241.
12.
Forastiere F., Corbo GM, Michelozzi P., Piselli R., Agabiti N., Brancato G., Ciappi G., Perucci CA: Effects of environment and passive smoking on the respiratory health of children. Int J Epidemiol1992;21:66-73.
13.
Reese AC, James IR, Laundau LI, Lesouef PN: Relationship between urinary cotinine level and diagnosis in children admitted to hospital. Am Rev Respir Dis1992; 146:66-70.
14.
De Francisco A., Morris J., Hall AJ, Amstrong Schellenberg JRM, Greenwood BM: Risk factors for mortality from acute lower respiratory tract infections in young Gambian children. Int J Epidemiol1993 ;22:1174-1182.
15.
Duff AL, Pomeranz ES, Gelber LE, Price GW, Farris H., Hayden FG, Platts-Mills Tae, Heymann PW: Risk factors for acute wheezing in infants and children: Viruses, passive smoke, and IgE antibodies to inhalant allergens. Pediatrics1993;92:535-540.
16.
Infante-Rivard C.: Childhood asthma and indoor environmental risk factors. Am J Epidemiol1993;137:834-844.
17.
Jin C., Rossignol AM: Effect of passive smoking on respiratory illness from birth to age eighteen months, in Shanghai, People's Republic of China. J. Pediatr1993;123:553-558.
18.
Rylander E. , Pershagen G., Eriksson M., Nordvall L.: Parental smoking and other risk factors for wheezing bronchitis in children. Eur J Epidemiol1993;9:517-526.
19.
Tager IB, Hanrahan JP, Tosteson TD, Castile RG, Brown RW, Weiss ST, Speizer FE: Lung function, pre- and post-natal smoke exposure, and wheezing in the first year of life. Am Rev Respir Dis1993;147:811-817.
20.
Yuksel B., Greenough A., Gamsu HR: Neonatal meconium aspiration syndrome and respiratory morbidity during infancy . Pediatr Pulmonol1993;15:358-361.
21.
Chen Y.: Environmental tobacco smoke, low birth weight, and hospitalization for respiratory disease. Am J Respir Crit Care Med1994; 150:54-58.
22.
Jee SH, Su IL, Kim IS: Passive smoking and acute respiratory infection of children in Korea ; in Slama K (ed): Proc 9th World Conf on Tobacco and Health, Paris, Oct 1994. New York, Plenum Press, 1994, pp 533-536.
23.
Azizi Bho, Zulkifli HI, Kasim S.: Indoor air pollution and asthma in hospitalized children in a tropical environment . J Asthma1995;32: 413-418.
24.
Bakoula CG, Kafritsa YJ, Kavadias GC, Lazopoulou DD, Theodoridou MC, Maravelias KP, Matsaniotis NS: Objective passive-smoking indicators and respiratory morbidity in young children . Lancet1995;346:280-281.
25.
Lewis S., Richards D., Bynner J., Butler N., Britton J.: Prospective study of risk factors for early and persistent wheezing in childhood . Eur Respir J1995;8:349-356.
26.
Lindfors A. , Wickman M., Hedlin G., Pershagen G., Rietz H., Nordvall SL: Indoor environmental risk factors in young asthmatics: A case control study. Arch Dis Child1995;73:408-412.
27.
Martinez FD , Wright AL, Taussig LM, Holberg CJ, Halonen M., Morgan WJ: Asthma and wheezing in the first six years of lifeN Engl J Med1995;332:133-138.
28.
Rylander E. , Pershagen G., Eriksson M., Bermann G.: Parental smoking, urinary cotinine and wheezing bronchitis in children. Epidemiology1995;6:289-291.
29.
Stoddard JL , Miller T.: Impact of parental smoking on the prevalence of wheezing respiratory illness in children. Am J Epidemiol1995; 141:96-102.
30.
Timonen KL, Pekkanen J., Korppi M., Vahteristo M., Salonin RO: Prevalence and characteristics of children with chronic respiratory symptoms in eastern Finland. Eur Respir J1995;8: 1155-1160.
31.
Volkmer RE, Ruffin RE, Wigg NR, Davies N.: The prevalence of respiratory symptoms in South Australian pre-school children. II. Factors associated with indoor air quality. J Paediatr Child Health1995;31:116-120.
32.
Altet N., Alcaide J., Plans P., Taberner JL, Salto E., Folguera L1, Salleras, L1: Passive smoking and risk of pulmonary tuberculosis in children immediately following infection: A case-control study. Tuber Lung Dis1996;77:537-544.
33.
Barber K., Mussin E., Taylor DK: Fetal exposure to involuntary maternal smoking and childhood respiratory disease . Ann Allergy Asthma Immunol1996;76:427-430.
34.
Gustafsson D. , Andersson K., Fagerlund I., Kjellman Nim: Significance of indoor environment for the development of allergic symptoms in children followed up to 18 months of age . Allergy1996;51:789-795.
O'Dempsey TJ , McArdle TF, Morris J., Lloyd-Evans N., Baldeh I., Laurence BE, Secka O., Greenwood BM: A study of risk factors for pneumococcal disease among children in a rural area of West Africa. Int J Epidemiol1996; 25:885-894.
38.
Robin LF, Lees Psj, Winget M., Steinhoff M., Moulton LH, Santosham M., Correa A.: Wood-burning stoves and lower respiratory illnesses in Navajo children. Pediatr Infect Dis J1996; 15:859-865.
39.
Rylander E. , Eriksson M., Pershagen G., Nordvall L., Ehrnst A., Ziegler T.: Wheezing bronchitis in children: Incidence, viral infections, and other risk factors in a defined population. Pediatr Allergy Immunol1996;7:6-11.
40.
Sears MR, Holdaway MD, Flannery EM, Herbison GP, Silva PA: Parental and neonatal risk factors for atopy, airway hyper-responsiveness, and asthma. Arch Dis Child1996;392-398.
41.
Wesley AG, Loening Wek: Assessment and 2-year follow-up of some factors associated with severity of respiratory infections in early childhood. S Afr Med J1996;86:365-368.
42.
Bearer C., Emerson RK, O'Riordan MA, Roitman E., Shackleton C.: Maternal tobacco smoke exposure and persistent pulmonary hypertension. Environ Health Pespect1997;105:202-206.
43.
Beckett WS, Belanger K., Gent JF, Holford TR, Leaderer, BP: Asthma among Puerto Rican Hispanics: A multi-ethnic comparison study of risk factors. Am J Respir Crit Care Med1996; 154:894-899.
44.
Burr ML, Merrett TG, Dunstan Fdj, Maguire MJ: The development of allergy in high-risk children. Clin Exp Allergy1997 ;27:1247-1253.
45.
Campbell H. : Indoor air pollution and acute lower respiratory infections in young Gambian children. Health Bull1997;55:20-31.
46.
ETAC Study Group: Determinants of total and specific IgE in infants with atopic dermatitis. Pediatr Allergy Immunol1997;8:177-184.
47.
Komoroski EM , Kirby RS, Rickert VI, Yamauchi T.: Risk factors for febrile, presumed viral illness in the first ten weeks of life. J Perinat Med1997;17:288-291.
48.
Margolis PA , Keyes LL, Greenberg RA, Bauman KE, LaVange LM: Urinary cotinine and parent history (questionnaire) as indicators of passive smoking and predictors of lower respiratory illness in infants. Pediatr Pulmonol1997;23:417-423.
49.
Nafstad P., Kongerud J., Botten G., Hagen JA, Jaakkola Jjk: The role of passive smoking in the development of bronchial obstruction during the first 2 years of life. Epidemiology1997 ; 8:293-297.
50.
Gergen PJ, Fowler JA, Maurer KR, Davis WW, Overpeck MD: The burden of environmental tobacco smoke exposure on the respiratory health of children 2 months through 5 years of age in the United States: Third National Health and Nutrition Examination Survey, 1988 to 1994. Pediatrics1998;101:e81-e86.
51.
Lister SM, Jorm LR: Parental smoking and respiratory illnesses in Australian children aged 0-4 years: ABS 1989-90 National Health Survey results. Aust N Z J Public Health1998;22: 781-786.
52.
Lodrup-Carlsen KC, Halvorsen R., Carlsen KH: Serum inflammatory and effects of age and tobacco smoke exposure in young non-asthmatic children. Acta Paediatr1998;87: 559-564.
53.
McBride CM, Lozano P., Curry SJ, Rosner D., Grothans LC: Use of health services by children of smokers and nonsmokers in a health maintenance organization. Am J Public Health1998;88:897-902.
54.
Piitulainen E., Sveger T.: Effect of environmental and clinical factors on lung function and respiratory symptoms in adolescents with α1 antitrypsin deficiency. Acta Paediatr1998;87: 1120-1124.
55.
Royo FG, Vera CG, Sevillano Fjr, Pujol EP, Hereza Jmj, Burgui Jam: Passive smoking and other risk factors associated to the lower respiratory illnesses in suckling infants. Aten Primaria1998;22:46-51.
56.
Tariq SM, Matthews Smm, Hakim EA, Stevens M., Arshad SH, Hide DW: The prevalence of and risk factors atopy in early childhood: A whole population birth cohort study. J Allergy Clin Immunol1998;101:587-593.
57.
Rugtveit J. : Environmental factors in the first months of life and the possible relationship to later development of hypersensitivity . Allergy1990;45:154-156.
58.
Chinn S., Rona RJ: Quantifying health aspects of passive smoking in British children aged 5-11 years. J Epidemiol Community Health1991;45:188-194.
59.
Dekker C., Dales R., Bartlett S., Brunekereef B., Zwanenburg H.: Childhood asthma and the indoor environment. Chest1991; 100:922-926.
60.
Call RC, Smith TF, Morris E., Chapman MD, Platts-Mills Tae: Risk factors for asthma in inner city children. J Pediatr1992 ;121:862-866.
61.
Ehrlich R., Kattan M., Godbold J., Saltzberg DS, Grimm KT, Landrigan PJ, Lilienfield DE: Childhood asthma and passive smoking: Urinary cotinine as a biomarker of exposure . Am Rev Respir Dis1992;145:594-599.
62.
Lebowitz MD , Sherrill D., Holberg CJ: Effects of passive smoking on lung growth in children. Pediatr Pulmonol1992;12:27-42.
63.
Martinez FD , Cline M., Burrows B.: Increased incidence of asthma in children of smoking mothers. Pediatrics1992;89:21-26.
64.
Bener A., Al-Frayh A., Ozkaragoz F., Al-Jawadi TQ: Passive smoking effects on wheezy bronchitis. Ann Saudi Med1993; 13:222-225.
65.
Chilmonczyk BA, Salmun LM, Megathlin KN, Neveux LM, Palomaki GC, Knight GJ, Pulkkinen AJ, Haddow JE: Association between exposure to environmental tobacco smoke and exacerbations of asthma in children. N Engl J Med1993;328:1665-1669.
66.
Hinton AE, Herdman Rcd, Martin-Hirsch D., Saeed SR: Parental cigarette smoking and tonsillectomy in children. Clin Otolaryngol1993; 18:178-180.
67.
Clark SJ, Warner JO, Dean TP: Passive smoking amongst asthmatic children: Questionnaire or objective assessment?Clin Exp Allergy1994;24:276-280.
68.
Flynn Mgl: Respiratory symptoms of rural Fijian and Indian children in Fiji. Thorax1994;49:1201-1204.
69.
Guneser S., Atici A., Alparslan N., Cinaz P.: Effects of indoor environmental factors on respiratory systems of children . J Trop Pediatr1994;40:114-116.
70.
Huss K., Rand CS, Butz AM, Eggleston PA, Murigande C., Thompson LC, Schneider S., Weeks K., Malveauz FJ: Home environmental risk factors in urban minority asthmatic children. Ann Allergy1994;72:173-177.
71.
Ogborn CJ, Duggan AK, DeAngelis C.: Urinary cotinine as a measure of passive smoke exposure in asthmatic children . Clin Pediatr1994; 33:220-226.
72.
Shaw R., Woodman K., Crane J., Moyes C., Kennedy J., Pearce N.: Risk factors for asthma symptoms in Kawerau children. N Z Med J1994;107:387-391.
73.
Leen MG, O'Connor T., Kelleher C., Mitchell EG, Loftus BG: Home environment and childhood asthma. Ir Med J1994;87:142-143.
74.
Braback L., Breborowicz A., Julge K., Knutsson A., Rijkjarv M-A., Vasa M., Bjorksten B.: Risk factors for respiratory symptoms and atopic sensitisation in the Baltic area. Arch Dis Child1995;72:487-493.
75.
Cuijpers Cej , Swaen Gmh, Wesseling GJ, Kessels F., Sturmans F., Wouters Efm: Adverse effects of the indoor environment on respiratory health in primary school children. Environ Res1995;68:11-23.
76.
Goren AY, Hellman S.: Respiratory conditions among school children and their relationship to environmental tobacco smoke and other combustion products. Arch Environ Health1995; 50:112-118.
77.
Henderson FW , Henry MM, Ivins SS, Morris R., Neebe EC, Len S-Y., Stewart PW: The Physicians of Raleigh Pediatrics Association PA: Correlates of recurrent wheezing in school-age children. Am J Respir Crit Care Med1995; 151:1786-1793.
78.
Kay J., Mortimer MH, Jaron AG: Do both paternal and maternal smoking influence the prevalence of childhood asthma? A study into the prevalence of asthma in children and the effects of parental smoking. J Asthma1995;32: 47-55.
79.
Lau YL, Darlberg J., Yeung CY: Prevalence of and factors associated with childhood asthma in Hong Kong. Acta Paediatr1995;64:820-822.
80.
LeSon S., Gershwin ME: Risk factors for asthmatic patients requiring intubation. I. Observations in children. J Asthma1995 ;32:285-294.
81.
LeSon S., Gershwin ME: Risk factors for asthmatic patients requiring intubation. II. Observations in teenagers. J Asthma1995;32:379-389.
82.
Mohamed N., Ng'ang'a L., Odhiambo J., Nyamwaya J., Menzies R.: Home environment and asthma in Kenyan schoolchildren: A case-control study . Thorax1995;50:74-78.
83.
Monafo V., De Amici M., Quaglini S., Pugni L., Ottolenghi A., Teracciano L., Burgio GR: Fumo passivo e livelli di IgE totali in eta scolare (Passive smoking and total IgE in school-age children). Riv ItalPediatr1995;21:675-680.
84.
Moyes CD, Weldon J., Ramades D., Crane J., Peerce N.: Respiratory symptoms and environmental factors in schoolchildren in the Bay of Plenty. N Z Med J1995;108:358-361.
85.
Soyseth V., Kongerud J., Boe J.: Postnatal maternal smoking increases the prevalence of asthma but not of bronchial hyper-responsiveness or atopy in their children. Chest1995;107:389-394.
86.
Strachan DP , Carey IM: Home environment and severe asthma in adolescence: A population based case-control study. Br Med J1995; 311;1053-1056.
87.
Wolf-Ostermann K., Luttmann H., Treiber-Klotzer C., Kreienbrock L., Wichmann HE: Cohort study on respiratory diseases and lung function in schoolchildren in Southwest Germany . Zentralbl Hyg1995;197:459-488.
88.
Aberg N., Sundell J., Eriksson B., Hesselmar B., Aberg B.: Prevalence of allergic diseases in schoolchildren in relation to family history, upper respiratory infections, and residential characteristics. Allergy1996;51:232-237.
89.
Chen Y., Rennie DC, Dosman JA: Influence of environmental tobacco smoke on asthma in nonallergic and allergic children. Epidemiology1996;7:536-539.
90.
Cunningham J., O'Connor GT, Dockery DW, Speizer FE: Environmental tobacco smoke, wheezing, and asthma in children in 24 communities. Am J Respir Crit Care Med1996; 153:318-324.
91.
Ehrlich R., Du Toit D., Jordaan E., Zwarenstein M., Potter P., Volmink JA, Weinberg E.: Risk factors for childhood asthma and wheezing: Importance of maternal and household smoking. Am J Respir Crit Care Med1996;154:681-688.
92.
El-Nawawy A. , Soliman AT, El-Azzouni O., El-Sayed A., Demian S., EI-Sayed M: Effect of passive smoking on frequency of respiratory illnesses and serum immunoglobulin-E (IgE) and interleukin-4 (IL-4) concentrations in exposed children. J Trop Pediatr1996 ;42:166-169.
93.
Lewis S., Butland B., Strachan D., Bynner J., Richards D., Butler N., Britton J.: Study of the aetiology of wheezing illness at age 16 in two national British birth cohorts. Thorax1996; 51:670-676.
94.
Lyons B., Frizelle H., Kirby F., Casey W.: The effect of passive smoking on the incidence of airway complications in children undergoing general anaesthesia. Anaesthesia1996;51: 324-326.
95.
Mannino DM, Siegel M., Huston C., Rose D., Etzel R.: Environmental tobacco smoke exposure and health effects in children: Results from the 1991 National Health Interview Survey. Tob Control1996;5:15-18.
96.
Moussa Maa, Skaik MB, Yaghy OY, Sal-wanes SB, Bin-Othman SA: Factors associated with asthma in school children. Eur J Epidemiol1996;12:583-588.
97.
Owen GO, Canter RJ, Robinson A.: Snoring, apnoea and ENT symptoms in the paediatric community. Clin Otolaryngol1996;21:130-134.
98.
Peters J., Hedley AJ, Wong CM, Lam TH, Ong SG, Liu J., Spiegelhalter DJ: Effects of an ambient air pollution intervention and environmental tobacco smoke on children's respiratory health in Hong Kong. Int J Epidemiol1996;25:821-828.
99.
Richards GA , Terblanche Aps, Theron AJ, Opperman L., Crowther G., Myer MS, Steenkamp J., Smith FC, Dowdeswell R., van der Merwe CA, Stevens K., Anderson R.: Health effects of passive smoking in adolescent children. S Afr Med J1996;86:143-147.
100.
Sears MR, Holdaway MD, Flannery EM, Herbison GP, Silva PA: Parental and neonatal risk factors for atopy, airway hyper-responsiveness, and asthma. Arch Dis Child1996;75:392-398.
101.
Strachan DP , Butland BK, Anderson HR: Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a national British. Br Med J1996;312: 1195-1199.
Austin JB, Russell G.: Wheeze, cough, atopy, and indoor environment in the Scottish Highlands. Arch Dis Child1997;76:22-26.
104.
Burr ML, Verrall C., Kaur B.: Social deprivation and asthma. Respir Med1997;91:603-608.
105.
Butland BK , Strachan DP, Anderson HR: The home environment and asthma symptoms in childhood: Two population based case-control studies 13 years apart. Thorax1997;52:618-624.
106.
Charlton A. , While D., Kelly S., Huang W.: Causes of absence from school related in children's and their parents' smoking. Tob Control1997;6:150-151.
107.
Forsberg B. , Pekkanen J., Clench-Aas J., Martensson N-B., Stjernberg N., Bartonova A., Timonen KL, Skerfving S.: Childhood asthma in four regions in Scandinavia: Risk factors and avoidance effects. Int J Epidemiol1997;26: 610-619.
108.
Goren AI, Hellmann S.: Changing prevalence of asthma among schoolchildren in Israel. Eur Respir J1997;10:2279-2284.
109.
Hemmelgarn B., Ernst P.: Airway function among Inuit primary school children in far northern Quebec. Am J Respir Crit Care Med1997;156:1870-1875.
110.
Hu FB, Persky V., Flay BR, Zelli A., Cooksey J., Richardson J.: Prevalence of asthma and wheezing in public school children: Association with maternal smoking during pregnancy. Ann Allergy Asthma Immunol1997;79: 80-84.
111.
Jedrychowski W., Flak E.: Symptoms of respiratory tract in schoolchildren exposed to indoor and outdoor air pollution. Pneumonol Alergol Pol1997;65:741-748.
112.
Jedrychowski W., Flak E.: Maternal smoking during pregnancy and postnatal exposure to environmental tobacco smoke as predisposition factors to acute respiratory infections. Environ Health Perspect1997; 105:302-306.
113.
Kaplan BA, Mascie-Taylor Cgn: Smoking and asthma among 23-year-olds. J Asthma1997;34:219-226.
114.
Lis G., Pietrzyk JJ: Association between air pollution and asthma prevalence in schoolchildren from Krakow. Pneumonol Alergol Pol1997;65:611-620.
115.
Leung R., Wong G., Lau J.Ho, A.Chan Jkw, Choy D., Douglass C., Lai Ckw: Prevalence of asthma and allergy in Hong Kong schoolchildren: An ISAAC study . Eur Respir J1997; 10: 354-360.
116.
Lilljeqvist A-C., Faleide AO, Watten RG: Low birthweight, environmental tobacco smoke and air pollution: Risk factors for childhood asthma? Pediatr AsthmaAllergy1997 ; 11:95-102.
117.
Lombardi E. , Morgan WJ, Wright AL, Stein RT, Holberg CJ, Martinez FD: Cold air challenge at age 6 and subsequent incidence of asthma: A longitudinal study. Am J Respir Crit Care Med1997;156:1863-1869.
118.
Maier WC, Arrighi HM, Morray B., Llewellyn C., Redding GJ: Indoor risk factors for asthma and wheezing among Seattle school children . Environ Health Perspect1997; 105:208-214.
119.
Ones U., Sapan N., Somer A., Disci R., Salman N., Guler N., Yalcin I.: Prevalence of childhood asthma in Istanbul, Turkey. Allergy1997;52: 570-575.
120.
Sanjuan Dms , Ramirez MS, Mendez Nhs, Medrano S., Cueto Smc: Exposición a contaminates y alergenos en el niño asmatico en comparación con el niño sano (Exposure to pollutants and allergens in the asthmatic child compared with the healthy child). Rev Alerg Mex1997;44:13-16.
121.
Schafer T., Dirschedl P., Kunz B., Ring J., Uberla K.: Maternal smoking during pregnancy and lactation increases the risk for atopic eczema in the offspring. J Am Acad Dermatol1997;36:550-556.
122.
Selcuk ZT, Caglar T., Enunlu T., Topal T.: The prevalence of allergic diseases in primary school children in Edirne, Turkey. Clin Exp Allergy1997;27:262-269.
123.
Squillace SP, Sporik RB, Coutre N., Lawrence A., Merriam S., Zhang J., Platts-Mills Tae: Sensitization to dust mites as a dominant risk factor for asthma among adolescents living in central Virginia. Am J Respir Crit Care Med1997;156:1760-1764.
124.
Wennergren G., Amark M., Amark K., Oskarsdottir S., Sten G., Redfors S.: Wheezing bronchitis reinvestigated at the age of 10 years. Acta Paediatr1997;86:351-355.
125.
Yang CY, Chiu JF, Cheng MF, Lin MC: Effects of indoor environmental factors on respiratory health of children in a subtropical climate. Environ Res1997 ;75:49-55.
126.
Zavras AI, Al-Bultan T, Jackson A., White G.: Exposure to passive smoking and other predictors of reduced nasal volume in children 7 to 12 years old. J Clin PediatrDent1997;21: 295-303.
127.
Chhabra SK , Gupta CK, Chhabra P., Rajpal S.: Prevalence of bronchial asthma in schoolchildren in Delhi. J Asthma1998 ;35:291-296.
128.
Chen Y., Rennie DC, Lockinger LA, Dosman JA: Effect of environmental tobacco smoke on cough in children with a history of tonsillectomy or adenoidectomy. Eur Respir J1998;11:1319-1323.
129.
Farooqi IS , Hopkin JM: Early childhood infection and atopic disorder . Thorax1998;53: 927-932.
130.
Fischer PH , Kriz B., Martuzzi M., Woityniak B., Lebret E., van Reeuwijk H., Pikhart H., Briggs D., Gorynski P., Elliot P.: Risk factors indoors and prevalences of childhood respiratory health in four countries in Western and Central Europe. Indoor Air1998;8:244-254.
131.
Jedrychowski W., Flak E.: Effects of air quality on chronic respiratory symptoms adjusted for allergy among preadolescent children. Eur Respir J1998;11:1312-1318.
132.
Jedrychowdski W., Maugeri U., Flak E., Mroz E., Bianchi I.: Predisposition to acute respiratory infections among overweight preadolescent children: An epidemiologic study in Poland. PublicHealth1998;112:189-195.
133.
Kearney PM , Kearney PJ: The prevalence of asthma in schoolboys of travellers' families. Ir Med J1998;91:203-206.
134.
Knight JM, Eliopoulos C., Klein J., Greenwald M., Koren G.: Pharmacokinetic predisposition to nicotine from environmental tobacco smoke: A risk factor for pediatric asthma. J Asthma1998;35:113-117.
135.
Lam TH, Chung SF, Betson CL, Wong CM, Hedley AJ: Respiratory symptoms due to active and passive smoking in junior secondary school students in Hong Kong. Int J Epidemiol1998;27:41-48.
136.
Lewis PR, Hensley MJ, Wlodarczyk J., Toneguzzi RC, Westley-Wise VJ, Dunn T., Calvert D.: Outdoor air pollution and children's respiratory symptoms in the steel cities of New South Wales. Med J Aust1998;169:459-463.
137.
Lewis SA, Britton JR: Consistent effects of high socioeconomic status and low birth order, and the modifying effect of maternal smoking on the risk of allergic disease during childhood. Respir Med1998;92:1237-1244.
138.
McBride CM , Lozano P., Curry SJ, Rosner D., Grothans LC: Use of health services by children of smokers and nonsmokers in a health maintenance organization. Am J Public Health1998;88:897-892.
139.
Milligan Pjm , Brabin BJ, Kelly YJ, Pearson MG, Mahoney G., Dunne E., Heaf D., Reid J.: Association of spatial distribution of childhood respiratory morbidity with environmental dust pollution. J Toxicol Environ Health A 1998 ;55:169-184.
140.
Montefort S., Lenicker HM, Caruna S., Agius Muscat H: Asthma, rhinitis and eczema in Maltese 13-15 year old schoolchildren: Prevalence, severity and associated factors (ISAAC). Clin Exp Allergy1997;28:1089-1099.
141.
Normann NE , Nystrom L., Jonsson E., Stjernberg N.: Prevalence and incidence of asthma and rhinoconjunctivitis in Swedish teenagers. Allergy1998;53:28-35.
142.
Peters J., McCabe CJ, Hedley AJ, Lam TH, Wong CM: Economic burden of environmental tobacco smoke on Hong Kong families: Scale and impact. J Epidemiol Community Health1998 ;52:53-58.
143.
Ronmark E. , Lundback B., Jonsson E., Platts-Mills T.: Asthma, type-1 allergy and related conditions in 7- and 8-year old children in Northern Sweden: Prevalence rates and risk factor pattern. Respir Med1998 ;92:316-324.
144.
Saraclar Y. , Sekerel BE, Kalayci O., Cetinkaya F., Adalioglu G., Tuncer A., Tezcan S.: Prevalence of asthma symptoms in school children in Ankara, Turkey. Respir Med1998;92:203-207.
145.
Skolnick DT , Vomvolakis MA, Buck KA, Mannino SF: Exposure to environmental tobacco smoke and the risk of adverse respiratory events in children receiving general anesthesia . Anesthesiology1998;88:1144-1153.
146.
Withers NJ , Low L., Holgate ST, Clough JB: The natural history of respiratory symptoms in a cohort of adolescents. Am J Respir Crit Care Med1998;158:352-357.
147.
Yang C-Y., Lin M-C., Hwang K-C.: Childhood asthma and the indoor environment in a subtropical area. Chest1998;114:393-397.
148.
Yang C-Y., Tien Y-C., Hsieh H-H., Kao W-Y., Lin M-C.: Indoor environmental risk factors and childhood asthma: A case-control study in a subtropical area. Pediatr Pulmonol1998 ; 26:120-124.
149.
DiFranza JK , Lew RA: Morbidity and mortality in children with use of tobacco products by other people. Pediatrics1996 ;97:560-568.
150.
Strachan DP , Cook DG: Health effects of passive smoking. 1. Parental smoking and lower respiratory illness in infancy and early childhood. Thorax1997;52:905-914.
151.
Cook DG, Strachan DP: Health effects of passive smoking. 3. Parental smoking and prevalence of respiratory symptoms and asthma in school age children. Thorax1997;52:1081-1094.
152.
Strachan DP , Cook DG: Health effects of passive smoking. 6. Parental smoking and childhood asthma: Longitudinal and case-control studies. Thorax1998;53:204-212.
153.
Li Jsm , Peat JK, Xuan W., Berry G.: Meta-analysis on the association between environmental tobacco smoke (ETS) exposure and the prevalence of lower respiratory tract infection in early childhood. Pediatr Pulmonol1999;27:5-13.
154.
Greenland S.: Quantitative methods in the review of epidemiologic literature. Epidemiol Rev1987;9:1-30.
155.
Partanen T. : What's with epidemiologic meta-analysis?Scand J Work Environ Health1996; 22:241-242.
156.
Tweedie RL , Scott KJ, Biggerstaff BJ, Mengersen KL: Bayesian meta-analysis with application to studies of ETS and lung cancer. Lung Cancer1996; 14 (suppl 1):S171-S194.
157.
Bailar JC III: The promise and problems of meta-analysis . N Engl J Med1997;337:559-561.
158.
Bailar JC III: Passive smoking, coronary heart disease and meta-analysis. N Engl J Med1999;340:958-951.
159.
Givens GH, Smith DD, Tweedie RL: Publication bias in meta-analysis: A Bayesian data-augmentation approach to account for issues exemplified in the passive smoking debate. Stat Sci1997; 19:221-250.
160.
Egger M., Smith GD: Bias in location and education of studies. BMJ1998 ;316:61-66.
161.
Kawachi I. , Colditz GA: Invited commentary: Measurement error, and publication bias in studies of passive smoking. Am J Epidemiol1996; 144:909-915.
162.
Egger M., Schneider M., Davey Smith G: Spurious precision? Meta-analysis of observational studies. BMJ1998;316:140-144.
163.
Weed DL, Kramer BS: Induced-abortion, bias, and breast cancer: Why epidemiology hasn't reached its limit. J Natl Cancer Inst1996;88:1698-1700.
164.
LeLorier J. , Gregoire G., Benhaddad A., Lapierre J., Derderian F.: Discrepancies between meta-analyses and subsequent large randomized, controlled trials. N Engl J Med1997; 337:536-542.
165.
Freiman JA , Chalmers TC, Smith H. Jr, Kuebler RR: The importance of beta, the type II error and sample size in the design and interpretation of the randomized control trial. N Engl J Med1978;690-694.
166.
Hernberg S. : Significance testing of potential confounders and other properties of study groups. Scand J Work Environ Health1996; 22:315-316.
167.
Chia K-S.: Significant-itis - an obsession with the p-value. Scand J Work Environ Health1996;23:152-154.
168.
Hill AB: The environment and disease: Association and causation?Proc R Soc Med1965; 58:295-300.
169.
Witorsch RJ: Parental smoking and respiratory health and pulmonary function in children: A review of the literature and suggestions for future research; in Ecobichon DJ, Wu JM (eds): Environmental Tobacco Smoke. Lexington, Lexington Books, 1990, pp 205-226.
170.
Chen MF, Kimizuka G., Wang NS: Human fetal lung changes associated with maternal smoking during pregnancy . Pediatr Pulmonol1987;3:51-58.
171.
Taylor B., Wadsworth J.: Maternal smoking during pregnancy and lower respiratory tract illness in early life. Arch Dis Child1987;62: 786-791.
172.
Young S., LeSouef PN, Geelhoed GC, Stick SM, Turner KJ, Landau LI: The influence of a family history of asthma and parental smoking on airway responsiveness in early pregnancy. N Engl J Med1991;324:1168-1173.
173.
Hanrahan JP , Tager IB, Segal MR, Tosteson TD, Castile RG, Van Vunakis H, Weiss ST, Speizer FE: The effect of maternal smoking during pregnancy on early infant lung function. Am Rev Respir Dis1992 ;145:1129-1135.
174.
Kahn A., Groswasser J., Sottiaux M., Kelmanson I., Rebuffat E., Franco P., Dramaix M., Wayenberg JL: Prenatal exposure to cigarettes in infants with obstructive sleep apneas. Pediatrics1994;93:778-783.
175.
Cutz E., Perrin DG, Hackman R., Czegledy-Nagy EN: Maternal smoking and pulmonary neuroendocrine cells in sudden infant death syndrome. Pediatrics1996;98:668-672.
176.
Stick SM, Burton PR, Gurrin L., Sly PD, LeSouef PN: Effects of maternal smoking during pregnancy and a family history of asthma on respiratory function in newborn infants. Lancet1996;348:1060-1064.
177.
Hoo AF, Henschen M, Dezateux, Costeloe K., Stocks J.: Respiratory function among preterm infants whose mothers smoked during pregnancy . Am J Respir Crit Care Med1998; 158:700-705.
178.
Gold DR, Burge HA, Carey V., Milton DK, Platts-Mills T., Weiss ST: Predictors of repeated wheeze in the first year of life. Am J Respir Crit Care Med1999; 160:227-236.
179.
Milner AD, Marsh MJ, Ingram DM, Fox GP, Susiva C.: Effects of smoking in pregnancy on neonatal lung function. Arch Dis Child Fetal Neonatal Ed1999;80:F8-F14.
180.
Yusuf HR, Rochat RW, Baughman WS, Gargiullo PM, Perkins BA, Brantley MK, Stephens DS: Maternal cigarette smoking and invasive meningococcal disease: A cohort study among young children in metropolitan Atlanta, 1989-1996. Am J Public Health1999;89: 712-717.
181.
Cunningham J., Dockery DW, Speizer FE: Maternal smoking during pregnancy as a predictor of lung function in children. Am J Epidemiol1994;139:1139-1152.
182.
Abel EL: Smoking during pregnancy: A review of effects on growth and development of offspring. Hum Biol1980;52:593-625.
183.
Brooke OG, Anderson HR, Bland JM, Peacock JL, Stewart CM: Effects on birth weight of smoking, alcohol, caffeine, socioeconomic factors, and psychosocial stress. Br Med J1989;298:795-801.
184.
Cnattingius S., Forman MR, Berendes HW, Graubard BI, Isotalo L.: Effect of age, parity, and smoking on pregnancy outcome: A population-based study. Am J Obstet Gynecol1993;168:16-21.
185.
Harlow BL, Frigoletto FD, Cramer DW, Evans JK, LeFevre ML, Bain RP, McNellis D.: Determinants of preterm delivery in low-risk pregnancies: The RADIUS Study Group. J Clin Epidemiol1996;49:441-448.
186.
Kyrklund-Blomberg NB, Cnattingius S.: Preterm birth and maternal smoking: Risks related to gestational age and onset of delivery. Am J Obstet Gynecol1998;179:1051-1055.
187.
Castles A. , Adams EK, Melvin CL, Kelsch C., Boulton ML: Effects of smoking during pregnancy: Five meta-analyses. Am J Prev Med1999;16:208-215.
188.
Coates AL, Bergsteinsson H., Desmond K., Outerbridge EW, Beaudry PH: Long-term pulmonary sequelae of premature birth with and without idiopathic respiratory distress syndrome. J Pediatr1977 ;90:611-616.
189.
Chan KN, Noble-Jamieson CM, Elliman A., Bryan EM, Silverman M.: Lung function in children of low birth weight. Arch Dis Child1989;64:1284-1293.
190.
Abbasi S., Bhutani VK: Pulmonary mechanics and energetics of normal, non-ventilated low birthweight infants. Pediatr Pulmonol1990; 8:89-95.
191.
Ashworth A. : Effects of intrauterine growth retardation on mortality and morbidity in infants and young children. Eur J Clin Nutr1998;52(suppl 1):S34-S41.
192.
Chen Y., Li W., Yu S.: Influence of passive smoking and artificial feeding on hospitalization for respiratory illness in early childhood. Br Med J1986;293:303-306.
193.
Chen Y., Li W., Yu S., Qian W.: Chang-Ning epidemiologic study of children's health. I: Passive smoking and children's respiratory diseases. Int J Epidemiol 988;17:348-355.
194.
Chen Y.: Synergistic effect of passive smoking and artificial feeding on hospitalization for respiratory illness in early childhood. Chest1989;95:1004-1007.
195.
Wynder EL: Epidemiological issues in weak associations. Int J Epidemiol1990;19(suppl 1):S5-S7.
196.
Taubes G.: Epidemiology faces its limits (Special news report). Science1995;269:164-169.
