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Abstract

Aims: Little is known about the prevalence and characteristics of functional somatic syndromes (FSS) such as irritable bowel syndrome (IBS), fibromyalgia (FM), chronic fatigue syndrome (CFS), whiplash associated disorders (WAD), multiple chemical sensitivity (MCS), and bodily distress syndrome (BDS) in the general population when they are investigated simultaneously. Method: This cross-sectional study is based on the Danish Study of Functional Disorders (DanFunD) cohort consisting of 9656 adults from the general population. FSS and BDS were identified by questionnaires and characterized by age, sex, vocational training, physical health and comorbidity with physical and psychiatric disease. Results: In total, 16.3% (95% CI: 15.6–17.1) of the participants fulfilled the criteria for at least one FSS, ranging from 1.7% for WAD to 8.6% for CFS, and 16.1% (95% CI: 15.4–16.9) fulfilled the criteria for BDS. Cases had a high risk of poor self-perceived health, limitations in daily activities, and a high psychiatric comorbidity, all increasing with the number of syndromes in each individual. However, the associations differed across the various FSS. Mutual overlaps of IBS, FM and CFS were greater than could be expected by chance. Conclusions: FSS and BDS are prevalent in the adult Danish population, and cases have high risk of poor self-perceived health, limitation in daily activities, and psychiatric comorbidity. These associations were particularly strong for cases with multiple FSS and multi-organ BDS.

Keywords

Irritable bowel syndrome fibromyalgia chronic fatigue syndrome whiplash associated disorders multiple chemical sensitivity bodily distress syndrome

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References

Henningsen

Gundel

Kop

et al. Persistent physical symptoms as perceptual dysregulation: a neuropsychobehavioral model and its clinical implications. Psychosom Med 2018;80:422–1.

Rask

Ørnbøl

Rosendal

et al. Long-term outcome of bodily distress syndrome in primary care: a follow-up study on health care costs, work disability, and self-rated health. Psychosom Med 2017;79:345–357.

Lee

Johnson

Harris

et al. The resource utilisation of medically unexplained physical symptoms. SAGE Open Med 2016;4:2050312116666217.

Clauw

DJ.

Fibromyalgia: a clinical review. JAMA 2014;311:1547–55.

Chey

Kurlander

Eswaran

Irritable bowel syndrome: a clinical review. JAMA 2015;313:949–58.

Rossi

Pitidis

Multiple chemical sensitivity: review of the state of the art in epidemiology, diagnosis, and future perspectives. J Occup Environ Med 2018;60(2):138–46.

Dinos

Khoshaba

Ashby

et al. A systematic review of chronic fatigue, its syndromes and ethnicity: prevalence, severity, co-morbidity and coping. Int J Epidemiol 2009;38:1554–70.

Myrtveit

Skogen

Wenzel

et al. Somatic symptoms beyond those generally associated with a whiplash injury are increased in self-reported chronic whiplash. A population-based cross sectional study: the Hordaland Health Study (HUSK). BMC Psychiatry 2012;12:129–244X-12–129.

Wessely

Nimnuan

Sharpe

Functional somatic syndromes: one or many?

The Lancet 1999;354(9182):936–9.

10.

Nimnuan

Rabe-Hesketh

Wessely

et al. How many functional somatic syndromes? J Psychosom Res 2001;51:549–57.

11.

Fink

Schröder

One single diagnosis, bodily distress syndrome, succeeded to capture 10 diagnostic categories of functional somatic syndromes and somatoform disorders. J Psychosom Res 2010;68:415–26.

12.

Budtz-Lilly

Fink

Ørnbøl

et al. A new questionnaire to identify bodily distress in primary care: The ‘BDS checklist’. J Psychosom Res 2015;78:536–45.

13.

Janssens

Zijlema

Joustra

Rosmalen

Mood and anxiety disorders in chronic fatigue syndrome, fibromyalgia, and irritable bowel syndrome: results from the lifelines cohort study. Psychosom Med 2015;77:449–57.

14.

Joustra

Janssens

Bultmann

et al. Functional limitations in functional somatic syndromes and well-defined medical diseases. Results from the general population cohort LifeLines. J Psychosom Res 2015;79:94–9.

15.

McBeth

Tomenson

Chew-Graham

et al. Common and unique associated factors for medically unexplained chronic widespread pain and chronic fatigue. J Psychosom Res 2015;79:484–91.

16.

Creed

Tomenson

Chew-Graham

et al. The associated features of multiple somatic symptom complexes. J Psychosom Res 2018;112:1–8.

17.

Creed

Tomenson

Chew-Graham

et al. Multiple somatic symptoms predict impaired health status in functional somatic syndromes. Int J Behav Med 2013;20:194–205.

18.

Dantoft

Ebstrup

Linneberg

et al. Cohort description: The Danish Study of Functional Disorders. Clin Epidemiol 2017;9:127–39.

19.

Kay

Jørgensen

Redefining abdominal syndromes. Results of a population-based study. Scand J Gastroenterol 1996;31:469–75.

20.

White

Harth

Speechley

et al. Testing an instrument to screen for fibromyalgia syndrome in general population studies: the London Fibromyalgia Epidemiology Study Screening Questionnaire. J Rheumatol 1999;26:880–4.

21.

Chalder

Berelowitz

Pawlikowska

et al. Development of a fatigue scale. J Psychosom Res 1993;37:147–53.

22.

Kasch

Qerama

Kongsted

et al. Clinical assessment of prognostic factors for long-term pain and handicap after whiplash injury: a 1-year prospective study. Eur J Neurol 2008;15:1222–30.

23.

Multiple chemical sensitivity: a 1999 consensus. Arch Environ Health 1999;54:147–9.

24.

Lacour

Zunder

Schmidtke

et al. Multiple chemical sensitivity syndrome (MCS) – suggestions for an extension of the U.S. MCS-case definition. Int J Hyg Environ Health 2005;208:141–51.

25.

Ware

Jr Kosinski

Keller

SD.

A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity. Med Care 1996;34:220–33.

26.

Bioinformatics & Evolutionary Genomics. Calculate and draw custom made Venn diagrams. Available at: http://bioinformatics.psb.ugent.be/webtools/Venn/. Accessed 1 September 2017.

27.

Eliasen

Schröder

Fink

et al. A step towards a new delimitation of functional somatic syndromes: A latent class analysis of symptoms in a population-based cohort study. J Psychosom Res 2018;108:102–17.

28.

Goldberg

Reed

Robles

et al. Multiple somatic symptoms in primary care: a field study for ICD-11 PHC, WHO’s revised classification of mental disorders in primary care settings. J Psychosom Res 2016;91:48–54.

29.

Heidari

Afshari

Moosazadeh

Prevalence of fibromyalgia in general population and patients, a systematic review and meta-analysis. Rheumatol Int 2017;37:1527–39.

30.

Canavan

West

Card

The epidemiology of irritable bowel syndrome. Clin Epidemiol 2014;6:71–80.

31.

Petersen

Skovenborg

Rask

et al. Physical comorbidity in patients with multiple functional somatic syndromes. A register-based case-control study. J Psychosom Res 2018;104:22–8.

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Prevalence of functional somatic syndromes and bodily distress syndrome in the Danish population: the DanFunD study

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