Increased abdominal obesity,adverse psychosocial factors and shorter telomere length in subjects reporting early ageing;the MONICA Northern Sweden Study

Abstract

Background: The rate of biological ageing is individual and represents the steady decrease in physiological and mental functions. Adverse social factors have been shown to influence this process. Self-perceived early ageing (SEA) might be a useful indicator of early biological ageing and increased mortality risk. The aim of this population-based study was to identify markers of SEA, including telomere length. Methods: We studied 1502 subjects (744 men, 758 women) from Northern Sweden. These subjects underwent a physical examination, blood sampling (including telomere length) and completed a self-administered questionnaire about their subjective age, social situation, lifestyle, and self-rated health (SRH). Age- and SRH-adjusted statistical analyses were made comparing SEA subjects with same-sex controls. Results: In all, 7.9% of men and 12.1% of women reported SEA. These subjects had significantly (p<0.0001) wider waist circumference and higher body mass index than controls. SEA men showed higher fasting glucose and SEA women showed higher total cholesterol levels than controls (p=0.020 and p=0.015, respectively). In addition, SEA women more often reported infrequent physical exercise (p=0.006), mental problems (p=0.064) and worse SRH (p=0.001) than controls. In a random sub-sample, telomere length was significantly shorter in SEA subjects (n=139) than controls (n=301; p=0.02), but not after full adjustment for BMI. Conclusions: Self-perceived early ageing is not uncommon and is associated with abdominal obesity, poor self-rated health, lower education, and shorter telomere length. This could link adverse social factors with features of the metabolic syndrome as well as with early biological ageing, of importance for targeting preventive programmes.

Keywords

Ageing metabolic syndrome self-perceived smoking social telomere length

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References

Harman D. The aging process: major risk factor for disease and death . Proc Natl Acad Sci 1991;88:5360-3.

Benjamin H. Biologic versus chronologic age . J Gerontol 1949;2:217-27.

Adams JM , White M.

Biological ageing. A fundamental, biological link between socio-economic status and health?

Eur J Pub Health 2004;14:331-4.

Valdes AM , Andrew T. , Gardner JP , Kimura M. , Oelsner E. , Cherkas LF , et al. Obesity, cigarette smoking, and telomere length in women . Lancet 2005;366:662-4.

Brouilette S. , Singh RK , Thompson JR , Goodall AH , Samani NJ White cell telomere length and risk of premature myocardial infarction . Arterioscler Thromb Vasc Biol 2003; 23:842-6.

Fitzpatrick AL , Kronmal RA , Gardner JP , Psaty BM , Jenny NS , Tracy RP , et al. Leukocyte telomere length and cardiovascular disease in the Cardiovascular Health Study . Am J Epidemiol 2007;165:14-21.

Samani NJ , Boultby R. , Butler R. , Thompson JR , Goodall AH Telomere shortening in atherosclerosis . Lancet 2001;358:472-3.

Gardner JP , Li S. , Srinivasan SR , Chen W. , Kimura M. , Lu X. , Berenson GS , Aviv A. Rise in insulin resistance is associated with escalated telomere attrition . Circulation 2005;111: 2171-7.

Cherkas LF , Aviv A. , Valdes AM , Hunkin JL , Gardner JP , Surdulescu GL , Kimura M. , Spector TD The effects of social status on biological aging as measured by white-blood-cell telomere length . Aging Cell 2006;5:61-5.

10.

Nilsson PM , Engberg M. , Nilsson J-A. , Karlsmose B. , Lauritzen T. Adverse social factors predict early ageing in middle-aged men and women: the Ebeltoft Health Study, Denmark . Scand J Public Health 2003 ;31:1-6.

11.

Shanley DP , Kirkwood TB Caloric restriction and aging: a life-history analysis . Int J Evolution 2000 ;54:740-50.

12.

Rowe JW , Kahn RL Human aging: usual and successful . Science 1987;237:143-9.

13.

Nilsson P.

Premature ageing - the link between psychosocial risk factors and disease?

Med Hypotheses 1996;47:39-42.

14.

Epel ES , Blackburn EH , Lin J. , Dhabhar FS , Adler NE , Morrow JD , et al. Accelerated telomere shortening in response to life stress . Proc Natl Acad Sci 2004;101: 17312-15.

15.

Epel ES , Lin J. , Wilhelm FH , Wolkowitz OM , Cawthon R. , Adler NE , et al. Cell aging in relation to stress arousal and cardiovascular risk factors . Psychoneuroendocrinology 2006 ;31:277-87.

16.

Uotinen V. , Rantanen T. , Suutama T. Perceived age as a predictor of old age mortality: a 13-year prospective study . Age Ageing 2005;34:368-72.

17.

Vuorisalmi M. , Lintonen T. , Jylhä M. Global self-rated health data from a longitudinal study predicted mortality better than comparative self-rated health in old age . J Clin Epidemiol 2005;58:680-7.

18.

af Sillén U. , Nilsson J-A. , Månsson N-O. , Nilsson P. Self-rated health in relation to age and gender: influence on mortality risk in the Malmö Preventive Project . Scand J Public Health 2005;33:183-9.

19.

Stegmayr B. , Lundberg V. , Asplund K. The events registration and survey procedure in the Northern Sweden MONICA Project . Scand J Public Health 2003;31(Suppl. 61):9-17.

20.

Cawthon RM Telomere measurement by quantitative PCR . Nucleic Acids Res 2002;30(10): e47 .

21.

Grabowski P. , Hultdin M. , Karlsson K. , Tobin G. , Åleskog A. , Thunberg U. , et al. Telomere length as a prognostic parameter in chronic lymphocytic leukaemia with special reference to VH gene mutation status . Blood 2005;105: 4807-12.

22.

Nordfjäll K. , Larefalk Å. , Lindgren P. , Roos G. Telomere length and heredity: Indications of paternal inheritance . Proc Natl Acad Sci USA 2005;102:16374-8.

23.

Alberti Kgmm , Zimmet P. , Shaw J. , for the IDF Epidemiology Task Force Consensus Group. The metabolic syndrome - a new worldwide definition . Lancet 2005;366: 1059-62.

24.

Kuh D. A life course perspective on telomere length and social inequalities in aging . Aging Cell 2006;5:579-80.

25.

Cawthon RM , Smith KR , O'Brien E. , Sivatchenko A. , Kerber RA Association between telomere length in blood and mortality in people aged 60 years or older . Lancet 2003;361:393-5.

26.

Denton M. , Prus S. , Walters V. Gender differences in health: a Canadian study of the psychosocial, structural and behavioural determinants of health . Soc Sci Med 2004;58: 2585-600.

27.

Miner-Rubino K. , Winter DG , Stewart AJ Gender, social class, and the subjective experience of aging: self-perceived personality changes from early adulthood to late midlife . Personality Soc Psychol Bull 2004 ;30:1599-610.

28.

Deeg DJ , Driegsman DM Concepts of self-rated health: specifying the gender difference in mortality risk . Gerontologist 2003;43:376-86.

29.

Brouwer WBF , van Exel J. , Stolk EA Acceptability of less than perfect health states . Soc Sci Med 2005 ;60:237-46.

30.

Chandola T. , Brunner E. , Marmot M. Chronic stress at work and the metabolic syndrome: prospective study . BMJ 2006;332:521-5.

31.

Nilsson P. , Möller L. , Solstad K. Adverse effects of psychosocial stress on gonadal function and insulin levels in middle-aged males . J Internal Med 1995;237:479-86.

32.

Andersen JG Coping with long-term unemployment: economic security, labour market integration and well-being. Results from a Danish panel study, 1994-1999 . Int J Soc Welfare 2002;11:178-90.

33.

Isacson D. , Bingefors K. , von Knorring L. The impact of depression is unevenly distributed in the population . Eur Psychiatry 2005;20:205-12.

34.

Beutel ME , Weidner K. , Schwarz R. , Brähler E. Age-related complaints in women and their determinants based on a representative community study . Eur J Obstetr Gynecol Reproductive Biol 2004;117:204-12.

35.

Emmelin M. , Weinehall L. , Stegmayr B. , Dahlgren L. , Stenlund H. , Wall S. Self-rated ill-health strengthens the effect of biomedical risk factors in predicting stroke, especially for men - an incident case referent study . J Hypertens 2003;21:887-96.

36.

Bjorkan GA , Bachman SS , Norris AH Comparison of visually estimated age with physiologically predicted age as indicators of rates of aging . Soc Sci Med 1982;16:197-204.

37.

Bulpitt CJ , Shipley MJ , Broughton PM , Fletcher AE , Markowe HL , Marmot MG , et al. The assessment of biological age: a report from the Department of Environment Study . Aging Clin Exp Res 1994;6:181-91.

38.

Aviv A. Telomeres, sex, reactive oxygen species, and human cardiovascular aging . J Mol Med 2002;80:689-95.

39.

Bairey Merz CN , Dwyer J. , Nordstrom CK , Walton KG , Salerno JW , Schneider RH Psychosocial stress and cardiovascular disease: pathophysiological links . Behav Med 2002;27:141-7.

40.

Artandi SE Telomeres, telomerase, and human disease . N Engl J Med 2006;355:1195-7.

41.

Demakakos P. , Gjonca E. , Nazroo J. Age identity, age perceptions, and health: evidence from the English longitudinal study of ageing . Ann N Y Acad Sci 2007;1114: 279-87.