This study examines the association between lifestyle factors, chronic disease, body-indices, and the seroprevalence of Helicobacter pylori infection in Danish adults. The relationship between age at menarche and H. pylori infection is also assessed. A random sample of 3,608 Danish adults completed a questionnaire about lifestyle factors (smoking habits, alcohol consumption, and coffee and tea intake), doctor diagnosed chronic diseases (heart conditions, diabetes, chronic bronchitis, and hypertension), menarche, and socio-demographic factors. A total of 2,913 participants were eligible for the present study. Electrocardiographs were recorded and blood pressure and serum lipid levels (HDL cholesterol, triglyceride, and cholesterol) were measured. Height and weight were determined and body mass index (BMI) calculated. Sera were analysed with an enzyme-linked immunosorbent assay for the presence of H. pylori specific IgG antibodies. The seroprevalence of H. pylori infection was associated with weekly alcohol intake ≥6 drinks (odds ratio 0.7, 95% confidence interval 0.6-0.9) due to a low rate of H. pylori infection among wine drinkers (odds ratio 0.6, 95% confidence interval 0.5- 0.7). No associations were found with smoking habits or serum lipids. People with upper quartile BMI (≥26.8 kg/m 2) were more likely to be seropositive for antibodies to H. pylori (odds ratio 1.6, 95% confidence interval 1.1-2.4). Chronic bronchitis (odds ratio 1.6, 95% confidence interval 1.1-2.5) and unspecified heart condition (odds ratio 2.0, 95% confidence interval 1.1-3.3) was more often seen in IgG seropositive women than in uninfected women. The likelihood of being seropositive for IgG antibodies to H. pylori increased with age at menarche (odds ratio per year 1.10, 95% confidence interval 1.02-1.19). Previously reported associations with age and socioeconomic status were confirmed. We conclude that wine drinking is associated with lower rates of H. pylori infection in Danish adults. The seroprevalence of H. pylori infection is increased in people with high BMI. H. pylori infection may relate to a history of late menarche and chronic bronchitis in Danish women.
Kurata JH, Nogawa AN, Abbey DE, Petersen F.A prospective study of risk for peptic ulcer disease in Seventh-Day Adventists . Gastroenterology1992; 102: 902-9.
2.
Kato I., Nomura AMY, Stemmermann GN, Chyou P-H.A prospective study of gastric and duodenal ulcer and its relation to smoking, alcohol and diet. Am J Epidemiol1992; 135: 521-30.
3.
Sonnenberg A. , Wasserman IHAssociations of peptic ulcer and gastric cancer with other diseases in US veterans. Am J Publ Health1995; 85: 1252-5.
4.
Doll R., Peto R., Wheatley K., Gray R., Sutherland I.Mortality in relation to smoking: 40 years' observations on male British doctors . BMJ1994; 309: 901-10.
5.
Johnsen R., Forde OH, Straume G., Burhol PGAetiology of peptic ulcer: a prospective population study in Norway . J Epidemiol Community Health1994; 48: 156-60.
6.
Damon A., Polednak APConstitution, genetics, and body form in peptic ulcer: a review. J Chron Dis1967; 20: 787 - 802.
7.
The Eurogast Study Group.Epidemiology of, and risk factors for Helicobacter pylori infection among 3194 asymptomatic subjects in 17 populations. Gut1993; 34: 1672-6.
8.
Murray LJ, Bamford KB, O'Reilly DPJ, McCrum EE, Evans AEHelicobacter pylori infection: relation with cardiovascular risk factors, ischaemic heart disease, and social factors. Br Heart J1995; 74: 497-501.
9.
Gasbarrini G. , Pretolani S., Bonvicini F., et al. A population based study of Helicobacter pylori infection in a European country: the San Marino Study. Relations with gastrointestinal diseases. Gut1995; 36: 838-44.
10.
Murray LJ, McCrum EE, Evans AE, Bamford KBEpidemiology of Helicobacter pylori Infection among 4742 randomly selected subjects from Northern Ireland. Int J Epidemiol1997; 26: 880-7.
11.
Bonnevie O.Causes of death in duodenal and gastric ulcer . Gastroenterology1977; 73: 1000-4.
12.
Langman MJS , Cooke ARGastric and duodenal ulcers and their associated diseases. Lancet1976; i: 680-3.
13.
Medalie JH, Neufeld HN, Goldbourt U., Kahn HA, Riss E., Oron D.Association between blood-pressure and peptic-ulcer incidence. Lancet1970; ii: 1225-6.
14.
Sonnenberg A.Concordant occurrence of gastric and hypertensive diseases. Gastroenterology1988; 95: 42-8.
15.
Monson RRDuodenal ulcer as a second disease. Gastroenterology1970; 52: 712-6.
16.
Mendall MA, Goggin PM, Molineaux N., et al. Relation of Helicobacter pylori infection and coronary heart disease. Br Heart J1994; 71: 437-9.
17.
Patel P., Mendall MA, Carrington D., Strachan DP, Leatham E., Molineaux N.Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors. BMJ1995; 311: 711-4.
18.
Sandifer QD , Lo SV, Crompton G.Association may not be causal. BMJ1996; 312: 251.
19.
Whincup PH, Mendall MA, Perry IJ, Strachan DP, Walker M.Prospective relations between Helicobacter pylori infection, coronary heart disease, and stroke in middle aged men. Heart1996; 75: 568-72.
20.
Khurshid A. , Fenske T., Bajwa T., Bourgeois K., Vakil N.A prospective controlled study of Helicobacter pylori Seroprevalence in coronary artery disease. Am J Gastroenterol1998; 93: 717-20.
21.
Regnström J. , Jovinge S., Båvenholm P., et al. Helicobacter pylori seropositivity is not associated with inflammatory parameters, lipid concentrations and degree of coronary artery disease. J Intern Med1998 ; 243: 109-13.
22.
McDonagh TA , Woodward M., Morrison CE, et al. Helicobacter pylori infection and coronary heart disease in the North Glasgow MONICA population . Eur Heart J1997; 18: 1257- 60.
23.
Danesh J., Peto R.Risk factors for coronary heart disease and infection with Helicobacter pylori: meta-analysis of 18 studies. BMJ1998; 316: 1130-2.
24.
Levine DM, Parker TS, Donnelly TM, Walsh A., Rubin ALIn vivo protection against endotoxin by plasma high density lipoprotein . Proc Natl Acad Sci USA1993; 90: 1240-4.
25.
Mohanty S., Mishra SK, Das BES, et al. Altered plasma lipid profile in falciparum malaria. Ann Trop Med Parasitol1992; 86: 601-6.
26.
Patel P., Mendall MA, Khulusi S., Northfield TC, Strachan DPHelicobacter pylori infection in childhood: risk factors and effect on growth . BMJ1994; 309: 1119-23.
27.
Perri F., Pastore M., Leandro G., et al. Helicobacter pylori infection and growth delay in older children . Arch Dis Child1997; 77: 46-9.
28.
Rosenstock SJ, Andersen LP, Rosenstock C., Bonnevie O., Jorgensen T.Socio-economic factors in Helicobacter pylori infection among Danish adults. Am J Publ Health1996; 86: 1539-44.
29.
Jørgensen T.Prevalence of gallstones in a Danish population . Am J Epidemiol1987; 126: 912-21.
30.
Andersen LP , Espersen F., Souckova A., Sedlackova M., Soucek A.Isolation and preliminary evaluation of a low molecular (LMW) antigen preparation for improved detection of Helicobacter pylori IgG antibodies. Clin Diagnostic Lab Immun1995; 2: 156-9.
31.
Andersen LP, Rosenstock SJ, Bonnevie O., Jorgensen T.Seroprevalence of Immunoglobulin G, M, and A antibodies to Helicobacter pylori in an unselected Danish population. Am J Epidemiol1996; 143: 1157-64.
Siafakas NM, Vermeire P., Pride NB, et al. Optimal assessment and management of chronic obstructive pulmonary disease (COPD). Eur Respir J1995; 8: 1398-420.
34.
Blackburn H. , Keys A., Simonsen E.The electrocardiogram in population studies. A classification system. Circulation1960; 21: 1160-75.
35.
Hansen H.Living Conditions in Denmark. Compendium of Statistics. Copenhagen: Danmarks Statistik, 1984.
36.
Norusis MJSPSS for Windows. Advanced Statistics Release 6.0. Chicago : SPSS Inc., 1993: 2-30.
37.
Parsonnet J. , Blaser MJ, Perez-Perez GI, Hargrett-Bean N., Tauxe RVSymptoms and risk factors of Helicobacter pylori infection in a cohort of epidemiologists. Gastroenterology1992; 102: 41-6.
38.
Banatvala N. , Kashiwagi S., Abdi Y., Hayashi J., Hardie JM, Feldman RAH. pylori seroconversion and seroreversion in an Okinawan cohort followed for 10 years. Am J Gastroenterol1994; 89: 1300-62.
39.
Sipponen P. , Kosunen TU, Samloff IM, Heinonen OP, Siurala M.Rate of Helicobacter pylori acquisition among Finnish adults: a 15-year follow-up. Scand J Gastroenterol1996; 31: 229-32.
40.
Pearce DC, Peach HG, Farish SJHelicobacter pylori antibody titres in serum, plasma, and successively thawed specimens: implications for epidemiological studies. J Clin Pathol1996; 49: 1017-19.
41.
Kikendall JW , Evaul J., Johnson LFEffect of cigarette smoking on gastrointestinal physiology and non-neoplastic digestive disease . J Clin Gastroenterol1984; 6: 65-78.
42.
Schubert TT , Schubert AB, Ma CKSymptoms, gastritis, and Helicobacter pylori in patients referred for endoscopy. Gastrointestinal Endoscopy1992; 38: 357-60.
43.
Mitchell HM , Li YY, Hu PJ, et al. Epidemiology of Helicobacter pylori in Southern China: identification of early childhood as the critical period for acquisition. J Infect Dis1992; 166: 149-53.
44.
McCallion WA , Murray LJ, Bailie AG, Dalzell AM, O'Reilly DPJ, Bamford KBHelicobacter pylori infection in children: relation with current household living conditions . Gut1996; 39: 18-21.
45.
Friedman GD , Siegelaub MS, Seltzer CCCigarettes, alcohol, coffee and peptic ulcer . N Engl J Med1974 ; 290: 469-73.
46.
Christensen AH, Gjorup T., Andersen IB, Matzen P.Opinions in Denmark on the causes of peptic ulcer disease. A survey among Danish physicians and patients. Scand J Gastroenterol1994; 29: 305-8.
47.
Kauffmann F. , Brille D.Bronchial hypersecretion, chronic airflow limitation, and peptic ulcer. Am Rev Respir Dis1981; 124: 646-9.
48.
Mitz HS, Farber SSDemonstration of Helicobacter pylori in tracheal secretions. JAOA1993; 93: 87-91.
49.
Borkowski G. , Sudhoff H., Koslowski F., Hackstedt G., Radü H-J., Luckhaupt H.A possible role of Helicobacter pylori infection in the etiology of chronic laryngitis . Eur Arch Otorhinolaryngol1997; 254: 481-2.
50.
Tsang KW, Lam S-K., Lam W-K., et al. High seroprevalence of Helicobacter pylori in active bronchiectasis . Am J Respir Crit Care Med1998; 158: 1047-51.
51.
Krajden S., Fuksa M., Anderson J., et al. Examination of human stomach biopsies, saliva, and dental plaque for Campylobacter pylori. J Clin Microbiol1989; 27: 1397-8.
52.
McCormick PA , Sankey EA, Cardin F., Dhillon AP, McIntyre N., Burroughs AKCongestive gastropathy and Helicobacter pylori: an endoscopic and morphometric study . Gut1991; 32: 351-4.
53.
Fraser AG, Pounder RE, Burroughs AKGastric Secretion and peptic ulceration in cirrhosis. J Hepatol1993; 19: 171-82.
54.
Sonnenberg A., Müller-Lissner SA, Vogel E., et al. Predictors of duodenal ulcer healing and relapse. Gastroenterology1981; 81: 1061-7.
55.
Schubert TT , Bologna SD, Nensey Y., Schubert AB, Mascha EJ, Ma CKUlcer risk factors: interactions between Helicobacter pylori Infection, nonsteroidal use, and age. Am J Med1993; 94: 413-8.
56.
Robert A., Leung FW, Guth PHMorphological and functional gastric cytoprotection by prostaglandin in rats receiving absolute ethanol orally. Gut1992 ; 33: 444-51.
57.
Segawa K., Nakazawa T., Tsukamoto Y., et al. Chronic alcohol abuse leads to gastric atrophy and decreased gastric secretory capacity: a histological and physiological study. Am J Gastroenterol1988; 83: 373-9.
58.
Fong T-L., Dooley CP, Cohen H., et al. Helicobacter pylori infection in pernicious anemia. A prospective controlled study. Gastroenterology1991; 100: 328-32.
59.
Pretolani S. , Bonvicini F., Arienti V., et al. Late onset of menstrual cycle in H. pylori infected females in the general population. Int J Gastroenterol1996; 28 Suppl 2: 200-1.
60.
Balaban DH, Peura DA, Watson D., Rembold C., Shifflett J.Relationship between H. pylori infection and ischaemic heart disease . Gastroenterology1996; 110 Suppl: A106-422.
