The biological definition of Alzheimer's disease promoted by the Alzheimer's Association Working Group's new criteria relegates cognitive impairment to the background when defining the disease. However, cognitive syndromes, as plaques and tangles, are important biological phenomena, are part of the disease and not of the illness, and are objectively investigable. When well delineated, they show a close correlation with brain anatomy and neuropathology and are also few, relatively invariable, well-defined and well distinguishable from each other. Therefore, their detection retains a high value in suggesting the presence of the disease, which still must be confirmed by principle of exclusion.
JackCRJrAndrewsJSBeachTG, et al.Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's association workgroup. Alzheimers Dement2024; 20: 5143–5169.
2.
EisenbergL. Disease and illness distinctions between professional and popular ideas of sickness. Cult Med Psychiatry1977; 1: 9–23.
3.
HelmanCG. Disease versus illness in general practice. J R Coll Gen Pract1981; 31: 548–552.
4.
LachK. The difference between disease and illness. Mcgill J Med2013; 14: 20–21.
5.
JenningsD. The confusion between disease and illness in clinical medicine. Can Med Assoc J1986; 135: 865.
6.
CassellEJ. The healer's art: A new approach to the doctor-patient relationship. Philadelphia: JB Lippincott Company, 1976.
7.
BeachTGMalek-AhmadiM. Alzheimer’s disease neuropathological comorbidities are common in the younger-old. J Alzheimers Dis2021; 79: 389–400.
8.
WeintraubSMesulamM. With or without FUS, it is the anatomy that dictates the dementia phenotype. Brain2009; 132: 2906–2908.
9.
CubelliRDe BastianiP. 150 years after Leborgne: why is Paul Broca so important in the history of neuropsychology?Cortex2011; 47: 899e901.
10.
SbicigoJBPiccoloLDRBeckerN, et al.Current perspectives on the anatomo-clinical method in neuropsychology. Psychol Neurosci2016; 9: 198.
11.
LamBMasellisMFreedmanM, et al.Clinical, imaging, and pathological heterogeneity of the Alzheimer’s disease syndrome. Alzheimers Res Ther2013; 5: 1.
12.
McKhannGMKnopmanDSChertkowdH, et al.The diagnosis of dementia due to Alzheimer’s disease: recommendations from the national institute on aging-Alzheimer’s association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement2011; 7: 263–269.
13.
CrutchSJSchottJMRabinoviciGD, et al.Consensus classification of posterior cortical atrophy. Alzheimers Dement2017; 13: 870–884.
14.
Gorno-TempiniMLBrambatiSMGinexV, et al.The logopenic/phonological variant of primary progressive aphasia. Neurology2008; 71: 1227–1234.
15.
OssenkoppeleRPijnenburgYALPerryDC, et al.The behavioral/dysexecutive variant of Alzheimer’s disease: clinical, neuroimaging and pathological features. Brain2015; 138: 2732–2749.
16.
AlaviABarrioJRWernerTJ, et al.Suboptimal validity of amyloid imaging-based diagnosis and management of Alzheimer’s disease: why it is time to abandon the approach. Eur J Nucl Med Mol Imaging2020; 47: 225–230.
17.
PatilSAyubchaCTeichnerE, et al.Clinical applications of PET imaging in Alzheimer’s disease. PET Clin2025; 20: 89–100.
