Abstract
Background
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that significantly impairs cognitive function, emotional health, and daily living activities. Comprehensive Geriatric Assessment (CGA) is a multidisciplinary approach designed to optimize health outcomes in older adults, but its effectiveness in managing AD remains to be fully elucidated.
Objective
To evaluate the impact of CGA intervention on serum S100β levels and clinical outcomes in patients with AD.
Methods
In this prospective study, 120 patients diagnosed with AD were randomly assigned to either a Control group or an Intervention group. The Control group received standard treatment and routine care, while the Intervention group received individualized care plans based on CGA in addition to standard management. Primary outcomes included serum S100β levels, Alzheimer's Disease Assessment Scale–Cognitive Subscale (ADAS-Cog), Neuropsychiatric Inventory–Questionnaire (NPI-Q), Geriatric Depression Scale (GDS) scores, Mini-Nutritional Assessment (MNA) scores, Activities of Daily Living (ADLs), Instrumental Activities of Daily Living (IADLs), and Parkinson's Disease Questionnaire (PDQ-39) scores, assessed at baseline and during follow-up.
Results
Serum S100β levels remained stable in the Control group but significantly decreased in the Intervention group at 6 months. ADLs and IADLs scores were consistently higher in the Intervention group. Although ADAS-Cog and NPI-Q scores improved in both groups, the Intervention group demonstrated significantly lower NPI-Q scores at 6 months.
Conclusions
CGA intervention effectively enhances cognitive function, emotional well-being, mobility, and social interaction in patients with AD.
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