Abstract
We investigated whether immunoglobulin KM (κ marker) allotypes were associated with Alzheimer's disease (AD) individually and/or epistatically with APOE ε4, the strongest known genetic susceptibility factor for the disease. Results showed a significant (p = 0.01) interaction between KM and APOE ε4. In KM 3/3 homozygotes, APOE ε4 was strongly associated with AD (OR = 8.3); however, in non-KM 3/3 subjects, the association between APOE ε4 and AD was markedly lower (OR = 0.9) and non-significant. If confirmed, these results may identify a subgroup of the population with a markedly higher risk of developing AD, who might require a different preventive/treatment strategy.
Get full access to this article
View all access options for this article.
References
Supplementary Material
Please find the following supplemental material available below.
For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.
For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.
