Epistatic effects of immunoglobulin KM (κ marker) allotypes and APOE ε4 allele on the risk of Alzheimer's disease

Abstract

We investigated whether immunoglobulin KM (κ marker) allotypes were associated with Alzheimer's disease (AD) individually and/or epistatically with APOE ε4, the strongest known genetic susceptibility factor for the disease. Results showed a significant (p = 0.01) interaction between KM and APOE ε4. In KM 3/3 homozygotes, APOE ε4 was strongly associated with AD (OR = 8.3); however, in non-KM 3/3 subjects, the association between APOE ε4 and AD was markedly lower (OR = 0.9) and non-significant. If confirmed, these results may identify a subgroup of the population with a markedly higher risk of developing AD, who might require a different preventive/treatment strategy.

Keywords

Alzheimer's disease APOE immunoglobulin KM allotypes

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