Being the second most-frequent type of age-related neurodegenerative dementia, dementia with Lewy bodies (DLB) is currently exerting a huge burden on the healthcare system. Since DLB lacks a definitive biomarker profile, a diagnostic tool becomes indispensable for effectively distinguishing DLB from other neurodegenerative diseases with overlapping neuropathological and clinical features in their early stages. In this context, saliva could serve as a viable alternative to more invasive and costly methods, providing clear advantages in terms of safety and affordability. This is a commentary serving to contextualize the findings of D’Antonio et al., featured in the Journal of Alzheimer's Disease.
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