Abstract
Objective
Aortic stenosis is a common valvular disease in the elderly. This study aimed to investigate changes in whole blood viscosity (WBV), which reflects hemodynamic load and blood flow and is associated with cardiovascular diseases, after percutaneous and surgical interventions for aortic stenosis.
Methods
From 2019 to 2022, 200 patients undergoing Transcatheter Aortic Valve Implantation (TAVI) (n = 100) or bioprosthetic Aortic Valve Replacement (bAVR) (n = 100) were analyzed. WBV at low shear rate (LSR, 0.5 s−1) and high shear rate (HSR, 208 s−1) was calculated from the hematocrit and total protein using the De Simone formula. Pre- and 3-month values were compared using paired and independent t-tests, and correlations and multivariable regression were performed.
Results
The aortic valve area was negatively correlated with HSR (r = –0.340, p < 0.01) and LSR (r = –0.358, p < 0.01). At 3 months, HSR decreased by 0.95 ± 0.31 cP and LSR by 18.92 ± 6.32 cP (both p < 0.001). Reductions were significant in both groups without between-group differences and were mainly related to decreases in non-albumin protein fractions.
Conclusion
Both TAVI and bAVR markedly reduced WBV, independent of the intervention type. WBV may be a useful biomarker for monitoring hemorheological and protein-based changes following valve intervention.
Keywords
Get full access to this article
View all access options for this article.
References
Supplementary Material
Please find the following supplemental material available below.
For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.
For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.
