Seven men with autistic disorders developed mood disorders or psychotic illnesses during adult life. This association has also been described in several previous reports. Although no firm conclusions can be drawn on the basis of case reports alone, it appears that autistic disorders may increase vulnerability to such psychoses. Possible reasons for the association are discussed, as is treatment.
AKUFFO, E. , MACSWEENEY, D.A. & GAJAWANI, A.K. (1986) ‘Multiple Pathology in a Mentally Handicapped Individual’, British Journal of Psychiatry149: 377-378.
2.
BURD, L. & KERBESHIAN, J. (1985) ‘Tourette Syndrome, Atypical Pervasive Developmental Disorder and Ganser Syndrome in a 15-Year-Old, Visually Impaired, Mentally Retarded Boy’, Canadian Journal of Psychiatry30: 74-75.
3.
CLARKE, D.J. , LITTLEJOHNS, C.S., CORBETT, J.A. & JOSEPH, S. (1989) ‘Pervasive Developmental Disorders and Psychoses in Adult Life’, British Journal of Psychiatry155: 692-699.
4.
CORBETT, J.A. (1979) ’Psychiatric Morbidity and Mental Retardation’, in P. SNAITH & F.E. JAMES (eds) Psychiatric Illness and Mental Handicap. London: Gaskell.
5.
DARR, G.C. & WORDEN, F.G. (1951) ‘Case Report Twenty-Eight Years after an Infantile Autistic Disorder’, American Journal of Orthopsychiatry21: 559-569.
6.
GHAZIUDDIN, M. & TSAI, L. (1991) ‘Depression in Autistic Disorder’, British Journal of Psychiatry159: 721-723.
7.
GHAZIUDDIN, M. , TSAI, L. & GHAZIUDDIN, N. (1991) ‘Fluoxetine in Autism with Depression’, Journal of the American Academy of Child and Adolescent Psychiatry30: 508-509.
8.
GILLBERG, C. (1985) ‘Asperger’s Syndrome and Recurrent Psychosis - A Case Study’, Journal of Autism and Developmental Disorders15: 389-397.
9.
JABLENSKY, A. (1986) ‘Epidemiology of Schizophrenia: A European Perspective’, Schizophrenia Bulletin12: 52-73.
10.
KERBESHIAN, J. & BURD, L. (1986) A Second Visually Impaired, Mentally Retarded Male with Pervasive Developmental Disorder, Tourette Disorder and Ganser Syndrome: Diagnostic Classification and Treatment’, International Journal of Psychiatry in Medicine16: 67-75.
11.
KERBESHIAN, J. & BURD, L. (1987) ‘Are Schizophreniform Symptoms Present in Attenuated Form in Children with Tourette Disorder and Other Developmental Disorders?’, Canadian Journal of Psychiatry32: 123-135.
12.
KERBESHIAN, J. , BURD, L. & FISCHER, W. (1987) ’Lithium Carbonate in the Treatment of Two Patients with Infantile Autism and Atypical Bipolar Symptomatology’, Journal of Clinical Psychopharmacology7: 401-405.
13.
KERBESHIAN, J. , BURD, L., RANDALL, T., MARTSOLF, J. & JALAL, S. (1990) ‘Autism, Profound Mental Retardation and Atypical Bipolar Disorder in a 33-Year- Old Female with a Deletion of 15q12’, Journal of Mental Deficiency Research34: 205-210.
14.
KOMOTO, J. , USUI, S. & HIRATA, J. (1984) ‘Infantile Autism and Affective Disorder’, Journal of Autism and Developmental Disorders14: 81-84.
15.
LAINHART, J.E. & FOLSTEIN, S.E. (1994) Affective Disorders in People with Autism: A Review of Published Cases’, Journal of Autism and Developmental Disorders24: 587-601.
16.
LINTER, C.M. (1987) ‘Short-Cycle Manic-Depressive Psychosis in a Mentally Handicapped Child without Family History’, British Journal of Psychiatry151: 554-555.
17.
MYERS, J.K. , WEISSMAN, M.M., TISCHLER, G.L., HOLZER, C.E., LEAF, P.J., ORVASCHEL, H., ANTHONY, J.C., BOYD, J.H., BURKE, J.D., KRAMER, M. & STOLTZMAN, R. (1984) ‘Six-Month Prevalence of Psychiatric Disorders in Three Communities’, Archives of General Psychiatry41: 959-967.
18.
PETTY, L.K. , ORNITZ, E.M. & MICHELMAN, J.D. (1984) ‘Autistic Children Who Become Schizophrenic’, Archives of General Psychiatry41: 129-135.
19.
PRASHER, V.P. & CLARKE, D.J. (1996) ‘Case Report: Challenging Behaviour in a Young Adult with Down’s Syndrome and Autism’, British Journal of Learning Disabilities24: 167-169.
20.
REID, A.H. (1976) ‘Psychiatric Disturbances in the Mentally Handicapped’, Proceedings of the Royal Society of Medicine69: 509-512.
21.
REISER, D.E. & BROWN, J.L. (1964) ‘Patterns of Later Development in Children with Infantile Psychosis’, Journal of the American Academy of Child Psychiatry3: 650-657.
22.
SOVNER, R. (1988) ‘Behavioral Psychopharmacology: A New Psychiatric Subspecialty’, in J. STARKET AL. (eds) Mental Retardation and Mental Health: Classification, Diagnosis, Treatment, Services, pp. 229-242. New York: Springer.
23.
SOVNER, R. (1989) ‘The Use of Valproate in the Treatment of Mentally Retarded Persons with Typical and Atypical Bipolar Disorders’, Journal of Clinical Psychiatry50, suppl. 3: 40-43.
24.
STEINGARD, R. & BIEDERMAN, J. (1987) ‘Lithium Responsive Manic-Like Symptoms in Two Individuals with Autism and Mental Retardation’, Journal of the American Academy of Child and Adolescent Psychiatry26: 932-935.
25.
SZATMARI, P. , BARTOLUCCI, G., FINLAYSON, A. & KRAMES, L. (1986) ‘A Vote for Asperger’s Syndrome’, Journal of Autism and Developmental Disorders16: 515-517.
26.
TANTAM, D. (1988) ‘Asperger’s Syndrome’, Journal of Child Psychology and Psychiatry29: 245-255.
27.
TANTAM, D. (1991) ‘Asperger Syndrome in Adulthood’, in U. FRITH (ed.) Autism and Asperger Syndrome, pp. 170-172. Cambridge: Cambridge University Press.
28.
WEISSMAN, M.M. & MYERS, J.K. (1978) ‘Affective Disorders in a United States Urban Community’, Archives of General Psychiatry35: 705-712.
29.
WING, L. (1980) Childhood Autism and Social Class: A Question of Selection?’, British Journal of Psychiatry137: 410-417.
30.
WING, L. (1981) ‘Asperger’s Syndrome: A Clinical Account’, Psychological Medicine11: 115-129.
31.
WOLFF, S. & CHICK, J. (1980) ‘Schizoid Personality in Childhood: A Controlled Follow-Up Study’, Psychological Medicine10: 85-100.
32.
WORLD HEALTH ORGANIZATION (1992) The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. Geneva: WHO.
33.
WORLD HEALTH ORGANIZATION (1993) The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. Geneva: WHO.
