Repetitive cognition, including rumination such as that seen in depression, has been shown to correlate with depression symptoms in both typically developing individuals and individuals with autism spectrum disorder. Repetitive cognition is more common in autism spectrum disorder than in typically developing peers, as is depression; thus, this study evaluated the role of repetitive cognition in relation between autism spectrum symptomatology and depressive symptomatology. In all, 200 typically developing adults completed self-report questionnaires measuring autism spectrum symptomatology, different forms of repetitive cognition (general perseveration and depressive rumination), depression, and rejection sensitivity. Perseveration was found to mediate the relation between autism spectrum symptoms and depression, and to partially mediate the relation between autism spectrum symptoms and rejection sensitivity. We conclude that it is of vital importance to consider cognition when considering depression in autism spectrum disorder.
American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Washington, DC.
2.
AndersonSMorrisJ (2006) Cognitive behaviour therapy for people with Asperger syndrome. Behavioural and Cognitive Psychotherapy34: 293–303.
3.
AustinEJ (2005) Personality correlates of the broader autism phenotype as assessed by the autism spectrum quotient (AQ). Personality and Individual Differences38(2): 451–460.
4.
AydukODowneyGKimM (2001) Rejection sensitivity and depressive symptoms in women. Personality and Social Psychology Bulletin27(7): 868–877.
5.
Baron-CohenSWheelwrightSSkinnerR. (2001) The autism-spectrum quotient (AQ): evidence from Asperger syndrome/high-functioning autism, males and females: scientists and mathematicians. Journal of Autism and Developmental Disorders31: 5–17.
6.
BishopSLHusVDuncanA. (2013) Subcategories of restricted and repetitive behaviors in children with autism spectrum disorders. Journal of Autism and Developmental Disorders43: 1287–1297.
7.
BoonstraAMOosterlaanJSergeantJA. (2005) Executive functioning in adult ADHD: a meta-analytic review. Psychological Medicine35: 1097–1108.
8.
BuckTRViskochilJFarleyM. (2014) Psychiatric comorbidity and medication use in adults with autism spectrum disorder. Journal of Autism and Developmental Disorders44: 3063–3071.
9.
CampbellDTFiskeDW (1959) Convergent and discriminant validation by the multitrait-multimethod matrix. Psychological Bulletin56(2): 81.
10.
Carcani-RathwellIRabe-HaskethSSantoshPJ (2006) Repetitive and stereotyped behaviours in pervasive developmental disorders. Journal of Child Psychology and Psychiatry and Allied Disciplines47: 573–581.
11.
ChowdhuryMBensonBAHillierA (2010) Changes in restricted repetitive behaviors with age: a study of high-functioning adults with autism spectrum disorders. Research in Autism Spectrum Disorders4: 210–216.
12.
CraneLGoddardLPringL (2013) Autobiographical memory in adults with autism spectrum disorder: the role of depressed mood, rumination, working memory and theory of mind. Autism17(2): 205–219.
13.
DowneyGFeldmanSI (1996) Implications of rejection sensitivity for intimate relationships. Journal of Personality and Social Psychology70(6): 1327–1343.
14.
DziobekIRogersKFleckS. (2008) Dissociation of cognitive and emotional empathy in adults with Asperger syndrome using the Multifaceted Empathy Test (MET). Journal of Autism and Developmental Disorders38(3): 464–473.
15.
EhringTZetscheUWeidackerK. (2011) The Perseverative Thinking Questionnaire (PTQ): validation of a content-independent measure of repetitive negative thinking. Journal of Behavior Therapy and Experimental Psychiatry42: 225–232.
16.
GadowKDGuttmann-SteinmetzSRieffeC. (2012) Depression symptoms in boys with autism spectrum disorder and comparison samples. Journal of Autism and Developmental Disorders42: 1353–1363.
17.
GhaziuddinMGhaziuddinNGredenJ (2002) Depression in persons with autism: implications for research and clinical care. Journal of Autism and Developmental Disorders32: 299–306.
18.
GothamKUnruhKLordC (2015) Depression and its measurement in verbal adolescents and adults with autism spectrum disorder. Autism19(4): 491–504.
19.
HarariHShamay-TsoorySGRavidM. (2010) Double dissociation between cognitive and affective empathy in borderline personality disorder. Psychiatry Research175(3): 277–279.
20.
HozaB (2007) Peer functioning in children with ADHD. Journal of Pediatric Psychology32: 655–663.
21.
IaoLSLeekamSR (2014) Nonspecificity and theory of mind: new evidence from a nonverbal false-sign task and children with autism spectrum disorders. Journal of Experimental Child Psychology122: 1–20.
22.
IngersollBMeyerKBeckerMW (2011) Increased rates of depressed mood in mothers of children with ASD associated with the presence of the broader autism phenotype. Autism Research4: 143–148.
23.
KernsCMKendallPC (2012) The presentation and classification of anxiety in autism spectrum disorder. Clinical Psychology: Science and Practice19: 323–347.
24.
KroenkeKSpitzerRLWilliamsJBW (2001) The PHQ-9: validity of a brief depression severity measure. Journal of General Internal Medicine16: 606–613.
25.
LernerMDMazefskyCAWhiteSW. (2017) Autism spectrum disorder. In: ButcherJHooleyJKendallPC (eds) American Psychological Association Handbook of Psychopathology. Washington, DC: American Psychological Association.
26.
MastenCLMorelliSAEisenbergerNI (2011) An fMRI investigation of empathy for “social pain” and subsequent prosocial behavior. Neuroimage55(1): 381–388.
27.
MaxwellSEColeDAMitchellMA (2011) Bias in cross sectional analyses of longitudinal mediation partial and complete mediation under an autoregressive model. Multivariate Behavioral Research46(5): 816–841.
28.
MayesSDCalhounSLMurrayMJ. (2011) Variables associated with anxiety and depression in children with autism. Journal of Developmental and Physical Disabilities23: 325–337.
29.
NijmeijerJSMinderaaRBBuitelaarJK. (2008) Attention-deficit/hyperactivity disorder and social dysfunctioning. Clinical Psychology Review28: 692–708.
30.
Nolen-HoeksemaS (2000) The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. Journal of Abnormal Psychology109(3): 504–511.
31.
Nolen-HoeksemaSWiscoBELyubomirskyS (2008) Rethinking rumination. Perspectives on Psychological Science3(5): 400–424.
32.
PatelSDayTNJonesN. (2017) Association between anger rumination and autism symptom severity, depression symptoms, aggression, and general dysregulation in adolescents with autism spectrum disorder. Autism21: 181–189.
33.
PearsonKAWatkinsERMullanEG (2011) Rejection sensitivity prospectively predicts increased rumination. Behaviour Research and Therapy49: 597–605.
34.
PearsonKAWatkinsERMullanEG. (2010) Psychosocial correlates of depressive rumination. Behaviour Research and Therapy48: 784–791.
35.
PetersonC (2014) Theory of mind understanding and empathic behavior in children with autism spectrum disorders. International Journal of Developmental Neuroscience39: 16–21.
36.
PivenJPalmerPJacobiD. (1997) Broader autism phenotype: evidence from a family history study of multiple-incidence autism families. American Journal of Psychiatry154: 185–190.
37.
PreacherKJKelleyK (2011) Effect size measures for mediation models: quantitative strategies for communicating indirect effects. Psychological Methods16(2): 93.
38.
RuzichEAllisonCSmithP. (2015) Measuring autistic traits in the general population: a systematic review of the Autism-Spectrum Quotient (AQ) in a nonclinical population sample of 6,900 typical adult males and females. Molecular Autism6: 2.
39.
ScheerenAMde RosnayMKootHM. (2013) Rethinking theory of mind in high-functioning autism spectrum disorder. Journal of Child Psychology and Psychiatry54(6): 628–635.
40.
SchuwerkTVuoriMSodianB (2015) Implicit and explicit theory of mind reasoning in autism spectrum disorders: the impact of experience. Autism19(4): 459–468.
41.
SenjuA (2012) Spontaneous theory of mind and its absence in autism spectrum disorders. The Neuroscientist18(2): 108–113.
42.
SmithCJLangCMKryzakL. (2009) Familial associations of intense preoccupations, an empirical factor of the restricted, repetitive behaviors and interests domain of autism. Journal of Child Psychology and Psychiatry, and Allied Disciplines50: 982–990.
43.
SpekAAvan HamNCNyklíčekI (2013) Mindfulness-based therapy in adults with an autism spectrum disorder: a randomized controlled trial. Research in Developmental Disabilities34: 246–253.
44.
SterlingLDawsonGEstesA. (2008) Characteristics associated with presence of depressive symptoms in adults with autism spectrum disorder. Journal of Autism and Developmental Disorders38: 1011–1018.
45.
TreynorWGonzalezRNolen-HoeksemaS (2003) Rumination reconsidered: a psychometric analysis. Cognitive Therapy and Research27(3): 247–259.
46.
TroybEKnochKHerlihyL. (2016) Restricted and repetitive behaviors as predictors of outcome in autism spectrum disorders. Journal of Autism and Developmental Disorders46: 1282–1296.
47.
UljarevićMEvansDWAlvaresGA. (2016) Short report: relationship between restricted and repetitive behaviours in children with autism spectrum disorder and their parents. Molecular Autism7: 29.
48.
WhiteSWOllendickTHBrayBC (2011) College students on the autism spectrum: prevalence and associated problems. Autism15: 683–701.
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