Abstract
We performed polysomnography on eight randomly chosen male patients who met Poser's criteria for definite multiple sclerosis (MS), to obtain an idea of the frequency and severity of sleep apnea (SA) in this population. Ages ranged from 27 to 67 years (mean, 50 years). The mean Kurtzke's disability score was 6.1. Only one complained of awakenings with shortness of breath. Otherwise, none had a history of sleep disorder or significant pulmonary disease. We found that two patients had an apnea index greater than 5, with oxygen desaturation to 60% in one. Two others had apnea indices less than 5, but had oxygen desaturation to 59% and 81% during the apneas. Two patients had apnea indices less than 5 without oxygen desaturation. The apneas were mainly central type, except in one who had a mixed central-obstructive pattern. These preliminary results suggest that SA in MS may be more frequent than suspected, and it can be associated to significant oxygen desaturation in some cases. The potential impact of SA in MS deserves further evaluation. Key Words: Sleep apnea—Multiple sclerosis—Automatic respiration—Central apneas—Apneas with central nervous system lesions.