Diagnosis of Mitochondrial Dysfunction in HIV-Infected Patients under Highly Active Antiretroviral Therapy: Possibilities beyond the Standard Procedures

Wallace C.D. Diseases of mitochondrial DNA. Annual Review of Biochemistry 1992; 61: 1175–1212.

Cardellach F. , Casademont J. , & Urbano-Marquez A. Mitocondriopatías secundarias. Revista de Neurologia 1998; 26 (Suppl 1): S81–S86.

Schapira A.H. Primary and secondary defects of the mitochondrial respiratory chain. Journal of Inherited Metabolic Disease 2002; 25: 207–214.

Casademont J. , Barrientos A. , Grau J.M. , Pedrol E. , Estivill X. , Urbano-Marquez A. , & Nunes V. The effect of zidovudine on skeletal muscle mtDNA in HIV-1 infected patients with mild or no muscle dysfunction. Brain 1996; 119: 1357–1364.

Zaera M.G. , Miro O. , Pedrol E. , Soler A. , Picon M. , Cardellach F. , Casademont J. , & Nunes V. Mitochondrial involvement in antiretroviral therapy-related lipodystrophy AIDS 2001; 15: 1643–1651.

Cote H.C. , Brumme Z.L. , Craib K.J. , Alexander C.S. , Wynhoven B. , Ting L. , Wong H. , Harris M. , Harrigan P.R. , O'Shaughnessy M.V. , & Montaner J.S. Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients. New England Journal of Medicine 2002; 346: 811–820.

Casademont J. , Miró O. , & Cardellach F. Mitochondrial DNA and nucleoside toxicity. New England Journal of Medicine 2002; 347: 217.

Walker U.A. , Bickel M. , Lutke Volksbeck S.I. , Ketelsen U.P. , Schofer H. , Setzer B. , Venhoff N. , Rickerts V. , & Staszewski S. Evidence of nucleoside analogue reverse transcriptase inhibitor-associated genetic and structural defects of mitochondria in adipose tissue of HIV-infected patients. Journal of Acquired Immune Deficiency Syndromes 2002; 29: 117–121.

Miro O. , Lopez S. , Pedrol E. , Rodriguez-Santiago B. , Martinez E. , Soler A. , Milinkovic A. , Casademont J. , Nunes V. , Gatell J.M. , & Cardellach F. Mitochondrial DNA depletion and respiratory chain enzyme deficiencies are present in peripheral blood mononuclear cells of HIV-infected patients with HAART-related lipodystrophy. Antiviral Therapy 2003; 8: 333–338.

Miro O. , Lopez S. , Martinez E. , Rodriguez-Santiago B. , Blanco J.L. , Milinkovic A. , Miro J.M. , Nunes V. , Casademont J. , Gatell J.M. , & Cardellach F. Short communication: reversible mitochondrial respiratory chain impairment during symptomatic hyperlactatemia associated with antiretroviral therapy. AIDS Research & Human Retroviruses 2003; 19: 1027–1032.

Cossarizza A. , & Moyle G. Antiretroviral nucleoside and nucleotide analogues and mitochondria. AIDS 2004; 18: 137–151.

Lopez S. , Miro O. , Martinez E. , Pedrol E. , Rodriguez-Santiago B. , Milinkovic A. , Soler A. , Garcia-Viejo M.A. , Nunes V. , Casademont J. , Gatell J.M. , & Cardellach F. Mitochondrial effects of antiretroviral therapies in asymptomatic patients. Antiviral Therapy 2004; 9: 47–55.

de Martino M. , Zammarchi E. , Filippi L. , Donati M.A. , Mannelli F. , Galli L. , & Vierucci A. Redox potential status in children with perinatal HIV-1 infection treated with zidovudine. AIDS 1995; 9: 1381–1383.

Armuzzi A. , Marcoccia S. , Zocco M.A. , De Lorenzo A. , Grieco A. , Tondi P. , Pola P. , Gasbarrini G. , & Gasbarrini A. Non-invasive assessment of human hepatic mitochondrial function through the ¹³ C-methionine breath test. Scandinavian Journal of Gastroenterology 2000; 35: 650–653.

Candelli M. , Cazzato I.A. , Zocco M.A. , Nista E.C. , Fini L. , Armuzzi A. , Camise V. , Santoro M. , Miele L. , Grieco A. , Gasbarrini G. , & Gasbarrini A. ¹³ C-breath tests in the study of mitochondrial liver function. European Review for Medical & Pharmacological Sciences 2004; 8: 23–31.

Milazzo L. , Riva A. , Sangaletti O. , Piazza M. , Antinori S. , & Moroni M. ¹³ C-methionine breath test detects liver mitochondrial impairment in HIV-infected patients with antiretroviral drug-related hyperlactatemia. Journal of Acquired Immune Deficiency Syndromes 2004; 35: 429–432.

Banasch M. , Goetze O. , Hollborn I. , Hochdorfer B. , Brockmeyer N. , Schmidt W.E. , & Schmitz F. Non-invasive assessment of hepatic mitochondrial toxicity in HIV-infected patients with normal serum lactate by ¹³C-methionine breath test. Antiviral Therapy 2004; 9: L19.

Versalovic J. Helicobacter pylori. Pathology and diagnostic strategies. American Journal of Clinical Pathology 2003; 119: 403–412.

ATS/ACCP. Statement on cardiopulmonary exercise testing. American Journal of Respiratory & Critical Care Medicine 2003; 167: 211–277.

Mayers J.N. The physiology behind exercise testing. Primary Care 2001; 28: 5–28.

Dandurand R.J. , Matthews P.M. , Arnold D.L. , & Eidelman D.H. Mitochondrial disease. Pulmonary function, exercise performance, and blood lactate levels. Chest 1995; 108: 182–189.

Taivassalo T. , Jensen T.D. , Kennaway N. , DiMauro S. , Vissing J. , & Haller R.G. The spectrum of exercise tolerance in mitochondrial myopathies: a study of 40 patients. Brain 2003; 126: 413–423.

Tesiorowski A.M. , Harris M. , Chan K.J. , Thompson C.R. , & Montaner J.S. Anaerobic threshold and random venous lactate levels among HIV-positive patients on antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes 2002; 31: 250–251.

Chapplain J.M. , Beillot J. , Begue J.M. , Souala F. , Bouvier C. , Arvieux C. , Tattevin P. , Dupont M. , Chapon F. , Duvauferrier R. , Hespel J.P. , Rochcongar P. , & Michelet C. Mitochondrial abnormalities in HIV-infected lipoatrophic patients treated with antiretroviral agents. Journal of Acquired Immune Deficiency Syndromes 2004; 37: 1477–1488.

Roge B.T. , Calbet J.A. , Moller K. , Ullum H. , Hendel H.W. , Gerstoft J. , & Pedersen B.K. Skeletal muscle mitochondrial function and exercise capacity in HIV-infected patients with lipodystrophy and elevated p-lactate levels. AIDS 2002; 16: 973–982.

Johnson J.E. , Anders G.T. , Blanton H.M. , Hawkes C.E. , Bush B.A. , McAllister C.K. , & Matthews J.I. Exercise dysfunction in patients seropositive for the human immunodeficiency virus. American Review of Respiratory Disease 1990; 141: 618–622.

Stringer W.W. Mechanisms of exercise limitation in HIV+ individuals. Medicine & Science in Sports & Exercise 2000; 32 (7 Suppl): S412–S421.

Munsat T.L. A standardized forearm ischemic exercise test. Neurology 1970; 20: 1171–1178.

Sanjurjo E. , Laguno M. , Bedini J.L. , Miro O. , & Grau J.M. Forearm ischemic exercise test. Standardization and diagnostic value in the identification of McArdle disease. Medicina Clinica 2004; 122: 761–766.

Clark J.B. , Bates T.E. , Boakye P. , Kuimov A. , & Land J.M. Investigation mitochondrial defects in brain and skeletal muscle. In A Practical Approach to the Investigation of Metabolic Disease, 1996, pp. 151–174. Edited by Turner A.J. , & Batchelard H.S. . Oxford: IRL Press, Oxford University Press.

Dysgaard Jeppesen T. , Olsen D. , & Vissing J. Cycle ergometry is not a sensitive diagnostic test for mitochondrial myopathy. Journal of Neurology 2003; 250: 293–299.

Jensen T.D. , Kazemi-Esfarjani P. , Skomorowska E. , & Vissing J. A forearm exercise screening test for mitochondrial myopathy. Neurology 2002; 58: 1533–1538.

Garrabou G. , López S. , Sanjurjo E. , Infante A. , Riba J. , Casademont J. , Cardellach F. , & Miró Ò . Mitochondrial dysfunction of HAART-related hyperlactataemia is demonstrable by non-invasive studies. Antiviral Therapy 2004; 9: L24.

Abe K. , Matsuo Y. , Kadekawa J. , Inoue S. , & Yanagihara T. Measurement of tissue oxygen consumption in patients with mitochondrial myopathy by noninvasive tissue oximetry. Neurology 1997; 49: 837–841.

Beekvelt M. , Engelen B. , Wevers R. , & Colier W. Quantitative near-infrared spectroscopy discriminates between mitochondrial myopathies and normal muscle. Annals of Neurology 1999; 46: 667–670.

Parry A. , & Matthews P.M. Roles for imaging in understanding the patophysiology, clinical evaluation, and management of patients with mitochondrial disease. Journal of Neuroimaging 2003; 13: 293–302.

Argov Z. , De Stefano N. , & Arnold D.L. ADP recovery after a brief ischemic exercise in normal and diseased human muscle - a ³¹P MRS study. NMR in Biomedicine 1996; 9: 165–172.

Matthews P.M. , Allaire C. , Shoubridge E.A. , Karpati G. , Carpenter S. , & Arnold D.L. In vivo muscle magnetic resonance spectroscopy in the clinical investigation of mitochondrial disease. Neurology 1991; 41: 114–120.

Mattei J.P. , Bendahan D. , & Cozzone P. P-31 magnetic resonance spectroscopy. A tool for diagnostic purposes and pathophysiological insights in muscle diseases. Reumatismo 2004; 56: 9–14.

Argov Z. Functional evaluation techniques in mitochondrial disorders. European Neurology 1998; 39: 65–71.

Cea G. , Bendahan D. , Manners D. , Hilton-Jones D. , Lodi R. , Styles P. , & Taylor D.J. Reduced oxidative phosphorylation and proton efflux suggest reduced capillary blood supply in skeletal muscle of patients with dermatomyositis and polymyositis: a quantitative 31P-magnetic resonance spectroscopy and MRI study. Brain 2002; 125: 1635–1645.