MurphyS.L.Deaths: final data for 1998. National Vital Statistics Report2000; 48: 1–105.
2.
NashD., FordyceE.J., SinghT., & ForlenzaS.Trends in mortality rates among reported Acquired Immune Deficiency (AIDS) case patients in New York City, 1990–1998.XIII International AIDS Conference, Durban, South Africa, 9–14 July, 2000; Abstract 3385.
3.
PalellaF.J., DelaneyK.M., MoormanA.C., LovelessM.O., FuhrerJ., SattenG.A., AschmanD.J., & HolmbergS.D.Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. New England Journal of Medicine1998; 338: 853–860.
LedergerberB., EggerM., OpravilM., TelentiA., HirschelB., BattegayM., VernazzaP., SudreP., FleppM., FurrerH., FrancioliP., & WeberR.Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: a prospective cohort study. Lancet1999; 353: 863–868.
6.
WitF.W., van LeewenR., WeverlingG.J., NautaK., SteingroverR., SchuijtemakerJ., EyssenX., FortuinD., WeedaM., de WolfF., ReissP., DannerS.A., & LangeJ.M.Outcome and predictors of failure of highly active anti-retroviral therapy: one year follow-up of a cohort of human immunodeficiency type-1-infected persons. Journal of Infectious Diseases1999; 179: 790–798.
7.
YamashitaT.Effect of prior treatment and host genotype on response to highly active antiretroviral therapy in the multicenter AIDS cohort study (MACS).XIII International AIDS Conference, Durban, South Africa, 9–14 July, 2000; Abstract 4089.
8.
AndreoniM., SarmatiL., NicastriE.Discordance between genotypic and phenotypic drug resistance in HIV-1 seropositive patients treated with two nucleoside analogues.XIII International AIDS Conference. Durban, South Africa, 9–14 July, 2000; Abstract 3290.
9.
CondraJ.H., PetropoulousC.J., ZiermannR., SchleifW.A., ShivaprakashM., & EminiE.A.Drug resistance and predicted virological responses to human immunodeficiency virus type 1 protease inhibitor therapy. Journal of Infectious Diseases2000; 182: 758–765.
10.
WeinstockH., ZaidiI., RepressR., HeineW., LuoC-C, WoodsT., HellmannN., LieY., & KaplanJ.Genotypic and phenotypic evidence of antiretroviral drug resistance among drug-naive persons recently diagnosed with HIV-1, USA, 1997–1999. Antiviral Therapy2000; 5 (Suppl. 3): 345–350.
11.
CroweS.M., & SonzaS.HIV-1 can be recovered from a variety of cells including peripheral blood monocytes of patients receiving highly active antiretroviral therapy: a further obstacle to eradication. Journal of Leukocyte Biology2000; 68: 345–350.
12.
VenturiG., CatucciM., RomanoL., CorsiP., LeonciniF., ValensinP.E., & ZazziM.Antiretroviral resistance mutations in human immunodeficiency virus type 1 reverse transcriptase and protease from paired cerebrospinal fluid and plasma samples. Journal of Infectious Diseases2000; 181: 740–745.
13.
AcostaE.P., KakudaT.N., BrundageR.C., AndersonP.L., & FletcherC.V.Pharmacodynamics of human immunodeficiency virus type 1 protease inhibitors. Clinical Infectious Diseases2000; 30: S151–S159.
14.
BurgerD.M., MeenhoorstP.L., & BeijenJ.H.Concise overview of the clinical pharmacokinetics of dideoxynucleoside antiretroviral agents. Pharmaceutical World Science1995; 17: 25–30.
15.
GerberJ.G.Using pharmacokinetics to optimize antiretroviral drug–drug interactions in the treatment of human immunodeficiency virus infection. Clinical Infectious Diseases2000; 30: S123–S129.
16.
CasadoJ.L., DrondaF., AntelaA.Pharmacokinetics of the combination of nevirapine, nelfinavir and saquinavirhgc in HIV-infected patients (NELSANE study).XIII International AIDS Conference, Durban, South Africa, 9–14 July, 2000; Abstract 3304.
17.
HoggR., YipB., ChanK., & Shaughnessy MontanerJ.Non-adherence to triple combination therapy is predictive of AIDS progression and death in HIV-positive men and women.XIII International AIDS Conference. Durban, South Africa, 9–14 July, 2000; Abstract 419.
18.
RuizL., NijhuisM., BoucherC., PuigT., BonjochA., Martinez-PicadoJ., MarfilS., de JongD., BurgerD., ArnoA., BalagueM., & ClotetB.Efficacy of adding indinavir to previous reverse transcriptase nucleoside analogues in relation to genotypic and phenotypic resistance development in advanced HIV-1-infected patients. Journal of Acquired Immune Deficiency Syndrome and Human Retroviruses1998; 19: 19–28.
19.
HsuA., WilliamsL., ChiuY-L, HillL., McMillanF., LammJ., RynkiewiczK., FoitC., JiQ., HutmanW., RyanJ., SunE., & JapourA.Pharmacokinetic (PK) interactions between ritonavir (RTV) and amprenavir (APV) in healthy volunteers.XIII International AIDS Conference, Durban, South Africa, 9–14 July, 2000; Abstract 546.
20.
LamotteC., DuvalX., PeytavinG., & FarinottiR.Amprenavir (APV) plasma concentrations are dramatically increased by association with ritonavir (RTV) baby-doses in HIV-infected patients (pts): possible combination with efavirenz (EFV).XIII International AIDS Conference, Durban, South Africa, 9–14 July, 2000; Abstract 4123.
21.
MorenoA., CasadoJ.L., Marte-BeldaP.Efficacy of the combination of ritonavir plus indinavir plus a non-nucleoside reverse transcriptase inhibitor in patients failing multiple antiretroviral regimens: pharmacokinetic and resistance data (NIVELPROT study).XIII International AIDS Conference, Durban, South Africa, 9–14 July, 2000; Abstract 4159.
22.
ZolopaA.R., ShulmanN., HavlirD., GallantJ., RaceE., JiangP., LamnJ., RenzC., KempfD., HsuA., & SunE.Ritonavir intensification of indinavir-containing antiretroviral regimens: the effect of increasing indinavir trough concentration and protease resistance on virological response. Antiviral Therapy2000; 5 (Suppl. 3): 75.
23.
SaagM.S., KilbyM., EhrensingE.Modulation of saquinavir steady-state pharmacokinetics with ‘baby’ doses of ritonavir in healthy volunteers.7th European Conference on Clinical Aspects and Treatment of HIV Infection, Lisbon, Portugal, 23–27 October, 1999; Abstract 829.
24.
KeplerT.B., & PerelsonA.S.Drug concentration heterogeneity facilitates the evolution of drug resistance. Proceedings of the National Academy of Science, USA1998; 95: 11514–11519.
25.
HoetelmansR.M., BurgerD.M., MeenhoorstP.L., & BeijenJ.H.Pharmacokinetic individualisation of zidovudine therapy. Current state of pharmacokinetic-pharmacodynamic relationships. Clinical Pharmacokinetics1996; 30: 314–327.
InabaT., FischerN.E., RiddickD.S., StewartD.J., & HidakaT.HIV protease inhibitors, saquinavir, indinavir and ritonavir: inhibition of CYP3A4-mediated metabolism of testosterone and binzoxazinorifamycin, KRM-1648, in human liver microsomes. Toxicology Letters1997; 93: 215–219.
28.
BackD.J., GibbonsS.E., KhooS.H., MerryC., BarryM.G., & MulcahyF.Therapeutic drug monitoring of antiretrovirals: Ready for the clinic? Diagnostic Technologies in the Management of HIV/AIDS and Other Life-Threatening Coinfectious Diseases: An IAPAC Symposium, Vienna, Austria, 10 October, 1999; Abstract.http://www.aegis.com/pubs/iapac/2000/IA000201.html.
29.
HoetelmansR.How will HIV therapeutic drug monitoring be used in clinical settings?40th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, Calif., USA, 26–29 September, 2000; Abstract 1172.
30.
HirschM.S., Brun-VezinetF., D'AquilaR.T., HammerS.M., JohnsonV.A., KuritzkesD.R., LovedayC., MellorsJ.W., ClotetB., ConwayB., DemeterL.M., VellaS., JacobsenD.M., & RichmanD.D.Antiretroviral drug resistance testing in adult with HIV infection. Recommendations of an International AIDS Society-USA Panel. Journal of the American Medical Association2000; 283: 2417–2426.
31.
BeanP.PMGFAD. Therapeutic drug monitoring of anti-retroviral agents. American Clinical Laboratories2000; 19: 20–22.
32.
HoetelmansR.M.Sanctuary sites in HIV-1 infection. Antiviral Therapy1998; 3: 13–15.
HillA., CraigC., & WhittakerL.Prediction of drug potency from Cmin/IC50 or Cmin/IC95 ratio: false precision. Antiviral Therapy2000; 5 (Suppl. 3): 50.
35.
van HeeswijkR.P., VeldkampA.I., MulderJ.W., MeenhorstP.L., WitF.W., LangeJ.M., DannerS.A., FoudraineN.A., KwakkelsteinM.O., ReissP., BeijnenJ.H., & HoetelmansR.M.The steady-state pharmacokinetics of nevirapine during once daily and twice daily dosing in HIV-1-infected individuals. AIDS2000; 14: F77–F82.
36.
KempfD., HsuA., JianP., RodeR., HertogsK., LarderB., ZolopaA., ShulmanN., HavlirD., GallantJ., RaceE., BollerS., SwerdlowJ., JasinskyO., RenzC., & SunE.Response to ritonavir (RTV) intensification in indinavir (IDV) recipients is highly correlated with virtual inhibitory quotient.8th Conference on Retroviruses and Opportunistic Infections, Chicago, Ill., USA, 4–8 February, 2001; Abstract 523.
37.
LarderB., KempS.D., & HertogsK.Quantitative prediction of HIV-1 phenotypic resistance from genotypes: the virtual phenotype (Virtual Phenotype). Antiviral Therapy2000; 5: 49.
38.
AIDS Clinical Trials Group Pharmacology Committee.Position paper on therapeutic drug monitoring for anti-retroviral drugs: Using drug concentrations to guide individual therapy.1998. http://www.hopkins-aids.edu/publications/report/jan00_4.html.
39.
PozniakA., GazzardB.G., BabikerA., BackD., DeutschJ., ChurchillD., FisherM., JohnsonM., LovedayC., MainJ., MoyleG., NelsonM., PetersB., PhilipsA., PillayD., PoppaA., TaylorC., WilliamsI., & YouleM.British HIV Association Guidelines for the treatment of HIV-infected adults with antiretroviral therapy.1999. http://www.aidsmap.com/about/bhiva/bhivagd.asp.
40.
MayersD.Both antiretroviral drug levels and drug resistance are associated with short-term virologic responses to subsequent drug regimens in CPCRA 046 (GART study).1st IAS Conference on HIV Pathogenesis and Treatment, Buenos Aires, Argentina, 8–11 July, 2001; Abstract 124.
41.
ClevenberghP., DurantJ., GarraffoR., KirstetterM., DauresJ.P., & Infectio-SUD Group. Usefulness of protease inhibitor therapeutic drug monitoring? PharmAdapt: A prospective multicentric randomized controlled trial: 12 weeks results.8th Conference on Retroviruses and Opportunistic Infections, Chicago, USA, Abstract 260B. Chicago, Ill., USA, 4–8 February, 2001; Abstract 260B.
42.
BurgerD., HugenP., DrosteJ., & HuitemaA.Therapeutic drug monitoring (TDM) of nelfinavir (NFV) and indinavir (IDV) in treatment-naive patients improves therapeutic outcome after 1 year: results from Athena.1st IAS Conference on HIV Pathogenesis and Treatment, Buenos Aires, Argentina, 8–11 July, 2001; Abstract 30.
PeterK., & GambertoglioJ.G.Intracellular phosphorylation of zidovudine (ZDV) and other nucleoside reverse transcriptase inhibitors (RTI) used for human immunodeficiency virus (HIV) infection. Pharmaceutical Research1998; 15: 819–825.
45.
StetcherB.N., PesceA.J., HurtubiseP.E., & FrameP.T.Pharmacokinetics of zidovudine phosphorylation in patients infected with the human immunodeficiency virus. Therapeutic Drug Monitoring1992; 14: 281–285.
46.
StretcherB.N., PescueA.J., MurrayJ.A., HurtubiseP.E., VineW.H., & FrameP.T.Concentrations of phosphorylated zidovudine (ZDV) in patients leukocytes do not correlate with ZDV dose or plasma concentrations. Therapeutic Drug Monitoring1991; 13: 325–331.
47.
HoetelmansR.M., MeehorstP.L., MulderJ.W., BurgerD.M., KoksC.H., & BeijnenJ.H.Clinical pharmacology of HIV protease inhibitors: focus on saquinavir, indinavir and ritonavir. Pharmaceutical World Science1997; 19: 159–175.
48.
SteinD.S., FishD.G., BielloJ.A., PrestonS.L., MartineauG.L., & DrusanoG.L.A 24-week, open-label phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir). AIDS1996; 10: 485–492.
49.
BurgerD.M., HoetelmansR.M., HugenP.W., MulderJ.W., MeenhorstP.L., KoopmansP.P., BrinkmanK., KeuterM., DolmansW., & HeksterY.A.Low plasma concentrations of indinavir are related to virological failure in HIV-1-infected patients on indinavir-containing triple therapy. Antiviral Therapy1998; 3: 215–220.
50.
HoetelmansR.M., ReijersM.H., WeverlingG.J., ten KateR.W., WitF.W., MulderJ.W., WeigelH.M., FrissenP.H., RoosM., JurriaansS., SchuitemakerH., De WolfF., BeijnenJ.H., & LangeJ.M.The effect of plasma drug concentrations on HIV-1 clearance rate during quadruple drug therapy. AIDS1998; 12: F111–F115.
51.
HarrisM., DurakovicC., RaeS., RaboudJ., FransenS., ShillingtonA., ConwayB., & MontanerJ.S.A pilot study of nevirapine, indinavir and lamivudine among patients with advanced human immunodeficiency virus disease who have had failure of combination nucleoside therapy. Journal of Infectious Diseases1998; 177: 1514–1520.
52.
MurphyR.L., SommadossiJ.P., LamsonM., HallD.B., MyersM., & DusekA.Antiviral effect and pharmacokinetic interaction between nevirapine and indinavir in persons infected with human immunodeficiency virus type1. Journal of Infectious Diseases1999; 179: 1116–1123.
53.
FletcherC.V., BrundageR.C., RemmelR. P., PageL.M., WellerD., CallesN.R., SimonC., & KlineM.W.Pharmacologic characteristics of indinavir, didanosine and stavudine in human immunodefificiency virus-infected children receiving combination therapy. Antimicrobial Agents & Chemotherapy2000; 44: 1029–1034.
54.
DielemanJ., GyssensI., van der EndeM., de MarieS., & BurgerD.M.Urological complaints in relation to indinivir plasma concentrations in HIV-infected patients. AIDS1999; 13: 473–478.
55.
DielemanJ., van RossumA-M, van der EndeM.High prevalence of subclinical nephrotoxicity with indinavir.XIII International AIDS Conference, Durban, South Africa, 9–14 July, 2000; Abstract 4264.
56.
SchapiroJ.M., WintersM.A., StewartF., EfronB., NorrisJ., KozalM.J., & MeriganT.C.The effect of high-dose saquinavir on viral load an CD4+ T-cell counts in HIV-infected patients. Annals of Internal Medicine1996; 124: 1039–1050.
57.
DannerS.A., CarrA., LeonardJ.M., LehmanL.M., GudiolF., GonzalesJ., RaventosA., RubioR., BouzaE., PintadoV.A short-term study of the safety, pharmacokinetics and efficacy of ritonavir, an inhibitor of HIV-1 protease. European-Australian Collaborative Ritonavir Study Group. New England Journal of Medicine1995; 333: 1528–1533.
58.
BurgerD.M., HugenP.W.H., AanoutseR.E., & HoetelmansRM on behalf of the ATHENA Study Group. Treatment failure of nelfinavir-containing triple therapy can largely be explained by low nelfinavir plasma concentrations. AIDS2000; 13: S89.
59.
DurantJ., ClevenberghP., GarraffoR., HalfonP., IcardS., del GiudiceP., MontagneN., SchapiroJ.M., & DellamonicaP.Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: pharmacological data from the Viradapt study. AIDS2000; 14: 1333–1339.
60.
MeadenE.R., BrownR.A., Hoggard, MaherB., KhooS.H., & BackD.J.Decreased P-glycoprotein but unaltered multidrug resistance-associated protein in HIV patients. AIDS2000; 14: S94.
61.
HuismanM.T., SmitJ.W., HoetelmansR.M.W., WiltshireR., BeijnenJ.H., & SchinkelH.The role of P-glycoprotein in oral bioavailability, brain and fetal penetration of the HIV protease inhibitor saquinavir. AIDS2000; 14 (Suppl. 4): S94.
62.
HennessyM., ClarkeS., Mulcahny, BerginC., TijaJ., BackD., & BarryM.Intracellular pharmacokinetics in HIV positive patients. AIDS2000; 14 (Suppl. 4): S97.
63.
ChooE.F., LeakeB., WandelC., ImamuraH., WoodA.J., WilkinsonG.R., & KimR.B.Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1protease inhibitors into brain and testis. Drug Metabolism Disposition2000; 28: 655–660.
64.
KimR.B., FrommM.F., WandelC., LeakeB., WoodA.J., RodenD.M., & WilkinsonG.R.The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. Journal of Clinical Investigation1998; 101: 289–294.
65.
CameronD.W., JapourA.J., XuY., HsuA., MellorsJ., FarthingC., CohenC., PoretzD., MarkowitzM., FollansbeeS., AngelJ.B., McMahonD., HoD., DevanarayanV., RodeR., SalgoM., KempfD.J., GrannemanR., LeonardJ.M., & SunE.Ritonavir and saquinavir combination therapy for the treatment of HIV infection. AIDS1999; 13: 213–224.
66.
SaahA., WinchellG., SenuikM., MehotaD., & DeutschP.Multiple-dose pharmacokinetics(PK) and tolerability of indinavir (IDV) and ritonavir (RTV) combinations in healthy volunteers.6th Conference on Retroviruses and Opportunistic Infections. Chicago, Ill., USA, 21 January – 4 February, 2000; Abstract 362.
GatellJ.M., LangeJ., ArnaizJ.A., FaetkenheuerG., MallolasJ., & ClotetB.A randomized study comparing continued indinavir (800 mg tid) to indinavir/ritonavir (800/100 mg bid) in HIV patients having achieved viral load suppression with indinavir plus 2 nucleosides analogues. The bid efficacy and safety trial (BEST).XIII International AIDS Conference, Durban, South Africa, 9–14 July, 2000; Abstract 484.
69.
JoshiA.S., BarrettJ.S., FiskeW.D.Population pharmacokinetics of efavirenz in Phase II studies and relationship with efficacy.39th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, Calif., USA, 26–29 September; Abstract 1201.
70.
MarzoliniC., TelentiA., DecosterdL.A., GreubG., BiollazJ., & BuclinT.Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients. AIDS2001; 15: 71–75.
71.
HavlirD., CheesemanS.H., McLaughlinM., MurphyR., EriceA., SpectorS.A., GreenoughT.C., SullivanJ.L., HallD., MyersM.High-dose nevirapine: safety, pharmacokinetics, and antiviral effect in patients with human immunodeficiency virus infection. Journal of Infectious Diseases1995; 171: 537–545.
72.
MontanerJ.S., ReissP., CooperD., VellaS., HarrisM., ConwayB., WainbergM.A., SmithD., RobinsonP., HallD., MyersM., & LangeJ.M.A randomized, double-blind trial comparing combinations of nevirapine, didanosine and zidovudine for HIV-infected patients: the INCAS Trial. Italy, the Netherlands, Canada and Australia Study. Journal of the American Medical Association1998; 279: 930–937.