Prevention of Mother-To-Child Transmission of HIV-1

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Nduati R. , John G. , Mbori-Ngacha D. , Richardson B. , Overbaugh , Mwatha A. , Ndinya-Achola J. , Bwayo J. , Onyango F.E. , Hughes J. , & Kreiss J. Effect of breastfeeding and formula feeding on transmission of HIV-1: a randomized clinical trial. Journal of the American Medical Association 2000; 283: 1167–1174.

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Sperling R.S. , Shapiro D.E. , Coombs R.W. , Todd J.A. , Herman S.A. , McSherry G.D. , O'Sullivan M.J. , Van Dyke R.B. , Jimenez E. , Rouzioux C. , Flynn P.M. , Sullivan J.L. , Spector S.A. , Diaz C. , Rooney J. , Balsley J. , Gelber R.D. , & Connor EM for the Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. Maternal viral load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant. New England Journal of Medicine 1996; 335: 1621–1629.

Melvin A.J. , Burchett S.K. , Watts D.H. , Hitti J. , Hughes J.P. , McLellan C.L. , King P.D. , Johnson E.J. , Williams B.L. , Frenkel L.M. , & Coombs R.W. Effect of pregnancy and zidovudine on viral load in HIV-1 infected women. Journal of Acquired Immune Deficiency Syndrome and Human Retroviruses 1997; 14: 232–236.

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Mandelbrot L. , Landreau-Mascaro A. , Rekacewicz C. , Berrebi A. , Benifla F.L. , Burgard M. , Lachassine E. , Barret B. , Chaix M.L. , Bongain A. , Ciraru-Vigneron N. , Crenn-Hebert C. , Delfraissy J.F. , Rouzioux C. , Mayaux M.J. , & Blanche S Agence Nationale de Recherches sur le SIDA (ANRS) 075 Study Group. Lamivudine-Zidovudine Combination for Prevention of Maternal-Infant Transmission of HIV-1. Journal of the American Medical Association 2001; 285: 2083–2093.

Saba J on behalf of the PETRA Trial Study Team. Interim analysis of early efficacy of three short ZDV/3TC combination regimens to prevent mother–to-child transmission of HIV-1: the PETRA Trial. 6th Conference on Retroviruses and Opportunistic Infections. Chicago, Illinois, USA, January–February, 1999. Abstract 57.

Wade N.A. , Birkhead G.S. , Warren B.L. , Charbonneau B.A. , French P.T. , Wang L. , Baum J.B. , Tesoriero J.M. , & Savicki R. Abbreviated regimens of zidovudine prophylaxis and perinatal transmission of the human immunodeficiency virus. New England Journal of Medicine 1998; 339: 1409–1414.

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WHO Collaborative Study Team on the Role of Breastfeeding on the Prevention of Infant Mortality. Effect of breastfeeding on infant and child mortality due to infectious diseases in less developed countries: a pooled analysis. Lancet 2000; 355: 345–455.

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Leroy V. , Newell M.L. , Dabis F. , Catherine Peckham , Van de Perre P. , Bulterys M. , Kind C. , Simonds R.J. , Wiktor S. , & Msellati P for the Ghent International working Group on Mother-to-Child Transmission of HIV. International multi-centre pooled analysis of late postnatal mother-to-child transmission of HIV-1 infection. Lancet 1998; 352: 597–600.

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Coutsoudis A. Method of feeding and transmission of HIV-1 from mothers to children by 15 months of age: prospective cohort study from Durban. XIIIth International AIDS Conference. Durban, South Africa, 9–13 July 2000. Abstract LbOr6.

Gray G. The PETRA study: early and late efficacy of three short ZDV/3TC combination regimens to prevent mother-to-child transmission of HIV-1. XIIIth International AIDS Conference, Durban, South Africa, 9–13 July 2000. Abstract LbOr05.

Deseyve M. , Duefield C. , Musisi M. , Fleming T. , Musoke P. , Guay L. , Mmiro F. , Jackson B. , & Owor M. The one year safety and efficacy data of the HIVNET 012 trial. XIIIth International AIDS Conference. Durban, South Africa, 9–13 July 2000. Abstract. LbOr1.

Garcia P.M. , Kalish L.A. , Pitt J. , Minkoff H. , Quinn T.C. , Burchett S.K. , Kornegay J. , Jackson B. , Moye J. , Hanson C. , Zorrilla C. , & Lew J.F. for The Women and Infants Transmission Study Group. Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission. New England Journal of Medicine 1999; 341: 394–402.

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Ekpini E. , Nkengasong J.N. , Sibailly T.S. , Diaby L. , Maurice C. , Bile C. , Monga B. , Roels T.H. , & Wiktor S.Z. Changes in plasma HIV-1 viral load and CD4 counts in HIV-1 infected women receiving short-course oral zidovudine to prevent mother-to-child transmission of HIV-1 in Abidjan, Cote d'Ivoire. XIIIth International AIDS Conference. Durban, South Africa, 9–13 July 2000. Abstract WePpB1301.

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Mmiro F. , Fleming T. , Deseyve M. , Ducar C. , Musoke P. , Guay L. , Donnell D. , Mofenson L. , & Jackson B. Association of maternal HIV viral load and perinatal transmission in the HIVNET 012 trial. XIIIth International AIDS Conference. Durban, South Africa, 9–13 July 2000. Abstract TuPpB1231.

Ionnidis J.P.A. , Abrams E.J. , Ammann A. , Bulterys M. , Goedert J.J. , Gray L. , Korber B.T. , Mayaux M.J. , Mofenson L.M. , Newell M.L. , Shapiro D.E. , Teglas J.P. , & Wilfert C.M. Perinatal transmission of HIV-1 from pregnant women with RNA viral load less than 1000 copies per ml. Journal of Infectious Disease 2001; 183: 539–545.

Wiktor S.Z. , Ekpini E. , Karon J.M. , Nkengasong J. , Maurice C. , Severin S.T. , Roels T.H. , Kouassi M.K. , Lackritz E.M. , Coulibaly I-M , & Greenberg A.E. Short course oral zidovudine for prevention of mother-to-child transmission of HIV-1 in Abidjan, Cote d'Ivoire: a randomized trial. Lancet 1999; 353: 781–785.

Dabis F. , Msellati P. , Meda N. , Welffens-Ekra C. , You B. , Manigart O. , Leroy V. , Simonon A. , Cartoux M. , Combe P. , Ouangre A. , Ramon R. , Ky-Zerbo O. , Montcho C. , Salamon R. , Rouzioux C. , Van der Perre P. , & Mandelbrot L. 6 month efficacy, tolerance, and acceptability of a short regimen of oral zidovudine to reduce vertical transmission of HIV in breastfed children in Cote d'Ivoire and Burkina Faso; a double blind placebo-controlled multicentre trial. DITRAME Study Group. Lancet 1999; 353: 786–792.

Culnane M. , Fowler M.G. , Lee S.S. , McSherry G. , Brady M. , O'Donnell K. , Mofenson L. , Gortmaker S.L. , Shapiro D.E. , Scott G. , Jimenez E. , Moore E.C. , Diaz C. , Flynn P.M. , Cunningham B. , & Oleske J. Lack of long-term effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women. Pediatric AIDS Clinical Trials Group Protocol 219/076 Teams. Journal of the American Medical Association 1999; 281: 151–157.

Hanson I.C. , Antonelli T.A. , Sperling R.S. , Oleske J.M. , Cooper E. , Culnane M. , Fowler M.G. , Kalish L.A. , Lee S.S. , McSherry G. , Mofenson L. , & Shapiro D.E. Lack of tumors in infants with perinatal HIV type 1 exposure and fetal/neonatal exposure to zidovudine. Journal of Acquired Immune Deficiency Syndrome 1999; 20: 463–467.

Blanche S. , Tardieu M. , Rustin P. , Slama A. , Barret B. , Ghislaine F. , Ciraru-Vigneron N. , Lacrois C. , Rouzioux C. , Mandelbrot L. , Desguerre I. , Rotig A. , Mayaux M-J , & Delfraissy J-F Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues. Lancet 1999; 354: 1084–1089.

Smith M.E. , US Nucleoside Safety Review Working Group. Ongoing nucleoside safety review of HIV-exposed children in US studies. 2nd Conference on Global Strategies for Prevention of HIV Transmission from Mothers to Infants. Montreal, Canada, September 1999. Abstract. 096.

Bulterys M. , Nesheim S. , Abrams E.J. , Palumbo P. , Farley J. , Lampe M. , Fowler M.G. , & Perinatal Safety Review Working Group. Lack of evidence of mitochondrial dysfunction in the offspring of HIV-infected women: retrospective review of perinatal exposure to antiretroviral drugs in the Perinatal AIDS Collaborative Study. Annals of the New York Academy of Science 2000; 918: 212–221.

Lang J. , Stellato R. , Brinkman K. , Wijburg F. , Haverkamp G. , Weverling G.J. , & Saba J for the PETRA Trial Management Committee. Review of neurologic adverse events in relation to mitochondrial dysfunction in the prevention of mother to child transmission of HIV: the PETRA study. 2nd Conference on Global Strategies for Prevention of HIV Transmission from Mothers to Infants. Montreal, Canada, September 1999. Abstract. 250.

Sullivan J. , Cunningham C. , Dorenbaum A. , Mofenson L. , Culnane M. , Gelber R. , & Britto Pl Genotypic resistance analysis in women participating in PACTG 316 with HIV-1 RNA ≥ 10,000 copies/ml. XIIIth International AIDS Conference. Durban, South Africa, 9–13 July 2000. Abstract. LbOr14.

Richman D. , Shih C.K. , Lowy I. , Rose J. , Prodanovich P. , Goff S. , & Griffin J. Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture. Proceedings of the National Academy of Sciences, USA 1991; 88: 11241–11245.

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Mracna M. , Guay L. , Dileanis J.A. , Musoke P. , Mmiro F. , Eshleman S.H. , & Jackson J.B. Selection of nevirapine (NVP) resistance mutations in Urgandan women and infants receiving NVP prophylaxis to prevent HIV-1 vertical transmission (HIVNET 012). XIIIth International AIDS Conference. Durban, South Africa, 9–13 July 2000. Abstract LbOr13.

Jackson J.B. , Becku-Pergola G. , Guay L. , Musoke P. , Mracna M. , Fowler M.G. , Mofenson L.M. , Mirochnick M. , Mmiro F. , Eshleman S.H. Identification of the K103N resistance mutation in Urgandan women receiving nevirapine to prevent HIV-1 vertical transmission. AIDS 2000; 14: F111–F115.

The International Perinatal HIV Group. The Mode of Delivery and the Risk of Vertical Transmission of Human Immunodeficiency Virus Type 1-A Meta-Analysis of 15 Prospective Cohort Studies. New England Journal of Medicine 1999; 340: 977–987.

The European Mode of Delivery Collaboration. Elective caesarean section versus vaginal delivery in prevention of vertical HIV-1 transmission: a randomized clinical trial. Lancet 199; 353: 1035–1039.

Akue J.P. , Babaki P. , Barre-Sinoussi F. , Charpak N. , de The G. , Rea M.F. , Huraux C. , Ndiaye B. , Pratomo H. , Samuel N.M. , Wilfert C. , & Zetterstrom R. Human Immunodeficiency virus type-1 mother-to-child transmission. Meeting of World Federation of Scientists in Erice, Italy, August 2000. Joint Report of AIDS/Infectious Disease PMP and Mother and Child PMP. Acta Paediatrica 2000; 89: 1385–1386.

Karita E. , Uwamaliya H. , Carmelinda S. , Munyangabe C. , Mpfizi B. , Tekirya E. , Rusanganwa E. , Shengero S. , Van Hoven D. Acceptability and feasibility of the introduction of a short regimen of oral zidovudine (ZDV) to reduce mother-to-child transmission (MTCT) of HIV in Rwanda. XIIIth International AIDS Conference. Durban, South Africa, 9–13 July 2000. Abstract WeOrC551.

Marseille E. , Kahn J.G. , Mmiro F. , Guay L. , Musoke P. , Fowler M.G. , & Jackson J.B. Cost effectiveness of single-dose nevirapine regimen for mothers and babies to decrease vertical HIV-1 transmission in sub-Saharan Africa. Lancet 1999; 354: 803–809.

Chorba T.L. , Sibailly T. , Ekpini E.R. , Noba V. , Nkengasong J. , Maurice C. , Kouassi M.K. , Roels T.H. , & Wiktor S.Z. Implementation and effectiveness of a short-course zidovudine and replacement feeding program to prevent mother-to-child transmission of HIV-1 in Abidjan, Cote d'Ivoire. XIIIth International AIDS Conference. Durban, South Africa, 9–13 July 2000. Abstract ThPpC1446.

Sibailly T.S. , Ekpini E.R. , Kamelan-Tanoh A. , Yavo D. , Maurice C. , Nkengasong J. , Roels T.H. , Wiktor S.Z. , & Chorba T.L. Impact of on-site HIV rapid testing with same-day post-test counseling on acceptance of short-course zidovudine for the prevention of mother-to-child transmission of HIV in Abidjan, Cote d'Ivoire. XIIIth International AIDS Conference. Durban, South Africa, 9–13 July 2000. Abstract We Or C549.

Second Conference HIV/AIDS Gaberone, Botswana, February, 2000.

Rantona K. , Tlou S. , Kidd R. , Field M.L. , Nyblade L. , & Sentumo S Programs to prevent mother-to-child transmission of HIV. A Botswana study of women's perspectives. XIIIth International AIDS Conference. Durban, South Africa, 9–13 July 2000. Abstract MoOrD207.

Perinatal HIV Intervention Research in Developing Countries Workshop Participants. Science, ethics, and the future of research into maternal infant transmission of HIV-1. Lancet 1999; 353: 832–835.