Chemotherapy-related cognitive impairment (CRCI) is one of the common adverse reactions experienced by colorectal cancer patients during chemotherapy. However, little is known about the experiences of colorectal cancer patients with CRCI. This study interviewed 12 patients with colorectal cancer. Three main themes were identified. Micro-systems represent the individual intra-experience of complex interactions (affected cognitive abilities; cognitively altered negative emotional experiences). Mesosystems as disordered life patterns (Frustration and self-deprecation in daily life; Family role imbalance in CRCI scenarios; Social withdrawal under cognitive impairment). The macro system is characterized by inadequate healthcare services and related policies. (Weak CRCI-related knowledge, longing for medical attention and home care guidance, dual pressures of CRCI on finances and employment). Research indicates that CRCI in colorectal cancer patients is complex and diverse. Effective intervention programs must be developed from multiple perspectives, including patients, families and healthcare institutions, to enhance their cognitive experience and fulfill their multidimensional needs.
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