This study tested depression as a mediator between childhood sexual abuse and adherence to antiretroviral therapy, an effect moderated by resilience. In total, 149 HIV+ Latino men who have sex with men were recruited for this study. Using a regression-based bootstrap approach, depression mediated the relationship between childhood sexual abuse and antiretroviral therapy adherence, with worse adherence for participants at lowest percentiles of the resilience index. The prevalence of childhood sexual abuse and depression in HIV+ men who have sex with men is high and must be addressed to better prevent disease progression and reduce transmission, especially in expanding Latino populations.
AmicoKRFisherWACornmanDH. (2006) Visual analog scale of ART adherence: Associations with 3-day self-report and adherence barriers. Journal of Acquired Immune Deficiency Syndromes42: 455–459.
2.
ArreolaSGNeilandsTBDíazR (2009) Childhood sexual abuse and the sociocultural context of sexual risk among adult Latino gay and bisexual men. American Journal of Public Health99: S432–S438.
3.
ArreolaSGNeilandsTBPollackLM. (2005) Higher prevalence of childhood sexual abuse among Latino men who have sex with men than non-Latino men who have sex with men: Data from the Urban Men’s Health Study. Child Abuse & Neglect29: 285–290.
4.
ArreolaSGNeilandsTBPollackLM. (2008) Childhood sexual experiences and adult health sequelae among gay and bisexual men: Defining childhood sexual abuse. Journal of Sex Research45: 246–252.
5.
BingEGBurnamMALongshoreD. (2001) Psychiatric disorders and drug use among human immunodeficiency virus-infected adults in the United States. Archives of General Psychiatry58: 721–728.
6.
BonannoGA (2004) Loss, trauma, and human resilience: Have we underestimated the human capacity to thrive after extremely aversive events?American Psychologist59: 20–28.
7.
BoudewynACLiemJH (1995) Childhood sexual abuse as a precursor to depression and self-destructive behavior in adulthood. Journal of Traumatic Stress8: 445–459.
8.
BraithwaiteRSJusticeACChangCH. (2005) Estimating the probabilities of patients infected with HIV who will die from comorbid diseases. American Journal of Medicine118: 890–898.
9.
CatzSLMcclureJBJonesGN. (1999) Predictors of outpatient medical appointment attendance among persons with HIV. AIDS Care11: 361–373.
ChesneyMAIckovicsJRChambersDB. (2000) Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: The AACTG adherence instruments. AIDS Care12: 255–266.
12.
CicchettiD (2010) Resilience under conditions of extreme stress: A multilevel perspective. World Psychiatry9: 145–154.
13.
CohenMSMcCauleyMGambleTR (2012) HIV treatment as prevention and HPTN 052. Current Opinions in HIV/AIDS7: 99–105.
14.
ConnorKMDavidsonJRT (2003) Development of a new resilience scale: The Connor–Davidson Resilience Scale (CD-RISC). Depression and Anxiety18: 76–82.
15.
DollLSJoyDBartholowBN. (1992) Self-reported childhood and adolescent sexual abuse among adult homosexual and bisexual men. Child Abuse & Neglect16: 855–864.
16.
FelittiVJAndaRFNordenbergD. (1998) Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. American Journal of Preventive Medicine14: 245–258.
17.
FerrandoSJFreybergZ (2008) Treatment of depression in HIV positive individuals: A critical review. International Review of Psychiatry20: 61–71.
18.
FriedlandGHWilliamsA (1999) Attaining higher goals in HIV treatment: The central importance of adherence. AIDS13(Suppl. 1): S61–S72.
19.
GiordanoTPGuzmanDClarkR. (2004) Measuring adherence to antiretroviral therapy in a diverse population using a visual analog scale. HIV Clinical Trials5: 74–79.
20.
GonzalezJSBatchelderAWPsarosC. (2011) Depression and HIV/AIDS treatment nonadherence: A review and meta-analysis. Journal of Acquired Immune Deficiency Syndrome58: 181–187.
21.
GrasLKesselringAMGriffinJT. (2007) CD4 cell counts of 800 cells/mm3 or greater after 7 years of highly active antiretroviral therapy are feasible in most patients starting with 350 cells/mm3 or greater. Journal of Acquired Immune Deficiency Syndrome45: 183–192.
22.
HayesAF (2009) Beyond Baron and Kenny: Statistical mediation analysis in the new millennium. Communication Monographs76: 408–420.
23.
HayesAF (2013) Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-Based Approach. New York: Guilford Press.
24.
HellerSSLarrieuJAD’ImperioR. (1999) Research on resilience to child maltreatment: Empirical considerations. Child Abuse & Neglect23: 321–338.
25.
HenryJ. Kaiser Family Foundation (2013) HIV/AIDS policy fact sheet: Latinos and HIV. Available at: http://www.kff.org/hivaids/6007.cfm (accessed 3 October 2013).
26.
HermannHStewartDEDiaz-GranadoN. (2011) What is resilience?Canadian Journal of Psychiatry56: 258–265.
27.
HerrickALLimSHWeiC. (2011) Resilience as an untapped resource in behavioral intervention design for gay men. AIDS and Behavior15: 25–29.
28.
HillbergTHamilton-GiachritsisCDixonL (2011) Review of meta-analyses on the association between child sexual abuse and adult mental health difficulties: A systematic approach. Trauma, Violence, & Abuse12: 38–49.
29.
IBM Corp. (2012) IBM SPSS Statistics for Windows (version 19.0). Armonk, NY: IBM Corp.
30.
JinichSPaulJPStallR. (1998) Childhood sexual abuse and HIV risk-taking behavior among gay and bisexual men. AIDS and Behavior2: 41–51.
31.
KentMDavisMCStarkSL. (2011) A resilience-oriented treatment for posttraumatic stress disorder: Results of a preliminary randomized clinical trial. Journal of Traumatic Stress24: 591–595.
32.
KurtzSPButtramMESurrattHL. (2012) Resilience, syndemic factors, and serosorting behaviors among HIV-positive and HIV-negative substance-using MSM. AIDS Education and Prevention24: 193–205.
33.
LesermanJ (2008a) Role of depression, stress, and trauma in HIV disease progression. Psychosomatic Medicine70: 539–545.
34.
LesermanJBarrosoJPenceBW. (2008b) Trauma, stressful life events and depression predict HIV-related fatigue. AIDS Care20: 1258–1265.
35.
LesermanJIronsonGO’CleirighC. (2008c) Stressful life events and adherence in HIV. AIDS Patient Care and STDs22: 403–411.
36.
LoprinziCEPrasadKSchroederDR. (2011) Stress Management and Resilience Training (SMART) program to decrease stress and enhance resilience among breast cancer survivors: A pilot randomized clinical trial. Clinical Breast Cancer11: 364–368.
37.
LuMSafrenSASkolnikPR. (2007) Optimal recall period and response task for self-reported HIV medication adherence. AIDS and Behavior12: 86–94.
38.
LutharSSCicchettiDBeckerB (2000) The construct of resilience: A critical evaluation and guidelines for future work. Child Development71: 543–562.
39.
MacKinnonDP (2008) Introduction to Statistical Mediation Analysis. Mahwah, NJ: Lawrence Erlbaum.
40.
MackinnonDPLueckenLJ (2008) How and for whom? Mediation and moderation in health psychology. Health Psychology72: S99–S100.
41.
ManiglioR (2010) Child sexual abuse in the etiology of depression: A systematic review of reviews. Depression and Anxiety27: 631–642.
42.
MastenAS (2001) Ordinary magic: Resilience processes in development. American Psychologist56: 227–238.
43.
MathieuJETaylorSR (2006) Clarifying conditions and decision points for meditational type inferences in organizational behavior. Journal of Organizational Behavior27: 1031–1056.
44.
MaxwellSEColeDA (2007) Bias in cross-sectional analyses of longitudinal mediation. Psychological Methods12: 23–44.
45.
MimiagaMJNoonanEDonnellD. (2009) Childhood sexual abuse is highly associated with HIV risk-taking behavior and infection among MSM in the EXPLORE study. Journal of Acquired Immune Deficiency Syndromes51: 340–348.
46.
MoreraOFCastroFG (2013) Important considerations in conducting statistical mediation analyses. American Journal of Public Health103: 394–396.
47.
O’CleirighCSafrenSAMayerKH (2012) The pervasive effects of childhood sexual abuse: Challenges for improving HIV prevention and treatment interventions. Journal of Acquired Immune Deficiency Syndromes59: 331–334.
48.
OyugiJHByakika-TusiimeJCharleboisED. (2004) Multiple validated measures of adherence indicate high levels of adherence to generic HIV antiretroviral therapy in a resource-limited setting. Journal of Acquired Immune Deficiency Syndromes36: 1100–1102.
49.
OzerEJBestSRLipseyTL. (2008) Predictors of posttraumatic stress disorder and symptoms in adults: A meta-analysis. Psychological Trauma: Theory, Research, Practice, and Policy1: 3–36.
50.
Page-ShaferKDelorenzeGNSatarianoWA. (1996) Comorbidity and survival in HIV-infected men in the San Francisco Men’s Health Survey. Annals of Epidemiology6: 420–430.
51.
PaolucciEGenuisMLViolatoC (2001) A meta-analysis of the published research on the effects of child sexual abuse. Journal of Psychology135: 17–36.
52.
PattersonTLShawWSSempleSJ. (1996) Relationship of psychosocial factors to HIV disease progression. Annals of Behavioral Medicine18: 30–39.
53.
PreacherKJKelleyK (2011) Effect size measures for mediation models: Quantitative strategies for communicating indirect effects. Psychological Methods16: 93–115.
54.
RothmanEFExnerDBaughmanAL (2011) The prevalence of sexual assault against people who identify as gay, lesbian, or bisexual in the United States: A systematic review. Trauma, Violence, & Abuse12: 55–66.
55.
SafrenSARadomskyASOttoMW. (2002) Predictors of psychological well-being in a diverse sample of HIV-positive patients receiving highly active antiretroviral therapy. Psychosomatics43: 478–485.
56.
SethiAJCelentanoDDGangeSJ. (2003) Association between adherence to antiretroviral therapy and human immunodeficiency virus drug resistance. Clinical Infectious Disease37: 1112–1118.
57.
SimoniJMHuhDWilsonIB. (2012) Racial/ethnic disparities in ART adherence in the United States: Findings from the MACH14 study. Journal of Acquired Immune Deficiency Syndromes60: 466–472.
58.
SimoniJMWiebeJSSaucedaJA. (2013) A preliminary RCT of CBT-AD for adherence and depression among HIV-positive Latinos on the U.S.-Mexico border: The Nuevo Dia study. AIDS and Behavior17: 2816–2829.
59.
StallRMillsTCWilliamsonJ (2003) Association of co-occurring psychosocial health problems and increased vulnerability to HIV/AIDS among urban men who have sex with men. American Journal of Public Health93: 939–942.
60.
Van Eeden-MoorefieldB (2008) A theory of resilience applied to couples affected by HIV/AIDS. Journal of LGBT Family Studies4: 433–452.
61.
WidomCSpatzSJCzajaTB. (2012) A prospective investigation of physical health outcomes in abused and neglected children: New findings from a 30-year follow-up. American Journal of Public Health102: 1135–1144.
62.
WiebeJSSaucedaJALaraC (2013) Assessing mood disorders and suicidality in Hispanics. In: BenutoLT (ed.) Guide to Psychological Assessment with Hispanics. New York: Springer, pp. 113–128.
