The current study examined the association between asthma and both smoking and nicotine dependence in the National Comorbidity Survey-Replication (NCS-R) as well as the temporal patterning between smoking and asthma onset (N = 5692; 53% female; M
age = 45.01, SD = 17.9). Results indicated lifetime history of daily smoking and nicotine dependence were both significantly associated with asthma diagnosis and half of individuals with asthma reported that their asthma diagnosis preceded smoking onset. These data suggest that nicotine dependence may maintain a stronger relation with asthma than smoking and that there may be distinct developmental trajectories for asthma—smoking relations.