This article reports the perception of the quality of work and the desire for supervision among physicians and nurses of a pediatric intensive care unit. Results indicated that, whereas staff members in general evaluated patient-related activities as challenging and attractive, they perceived organizational aspects of their work less positively and thus worthy of change. Notably, physicians rated the quality of their work environment higher and indicated more job satisfaction than nurses. Furthermore, senior doctors perceived themselves as better stress copers than other staff members. However, both professional groups demonstrated a strong wish for multidisciplinary team supervision. The findings indicate that supervision is essential when working in this context.