Antiphospholipid Syndrome

Conley C L Hartman R. C. A haemorrhagic disorder caused by circulating anticoagulant in patients with disseminated lupus erythematosus. J Clin Invest 1952; 31: 621–22.

Schleider M A Nachman R L Jaffe E A Coleman M. A clinical study of the lupus anticoagulant. Blood 1976; 48: 499–509.

Bowie E J Thompson J H Pascuzzi C A Owen C. A. Thrombosis in systemic lupus erythematosus despite circulating anticoagulants. J Lab Clin Med 1963; 63: 416–30.

Exner T. Rickard K A Kronenberg H. Studies on phospholipids in the action of a lupus coagulation inhibitor. Pathology 1975; 7: 319–28.

Laurell B-B Nilsson I. M. Hypergamma-globulinaemia, circulating anticoagulant, and biological false positive Wassermann reaction. J Lab Clin Med 1957; 49: 694–707.

Shapiro S. Thiagarajan P. Lupus anticoagulant. Prog Haemost Thromb 1982; 6: 263–85.

Harris E N Gharavi A E Boey M L . Anticardiolipin antibodies: Detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet 1983; 2: 1211–14.

Harris E N Gharavi A E Louizou S. . Cross-reactivity of antiphospholipid antibodies. J Clin Lab Immunol 1985; 16: 1–6.

Hughes G. R. V. Thrombosis, abortion, cerebral disease and the lupus anticoagulant. Br Med J 1983; 287: 1088–89.

Elias M. Eldor A. Thromboembolism in patients with the ‘lupus’ type circulating anticoagulant. Arch Intern Med 1984; 144: 510–15.

Moysan J F Jouquan J. Gerard C. Pennec Y. Le Goff P. Youinou P. Is the target of anticardiolipin antibodies the same in Gougerot–Sjögren's syndrome and lupus erythematosus disseminatus? Rev Med Intern 1987; 8: 163–68.

Hull R G Harris E N Gharavi A. E. Anticardiolipin antibodies: Occurrence in Beçhet's syndrome. Ann Rheum Dis 1984; 43: 746–48.

Saxe D A Roy D. A. Takayasu's arteritis syndrome associated with systemic lupus erythematosus. Semin Arthritis Rheum 1992; 21: 295–305.

Seibold J R Knight P J Peter J. B. Anticardiolipin antibodies in systemic sclerosis. Arthritis Rheum 1986; 29: 1052–53.

Rapaport S I Feinstein D. I. Lupus anticoagulant and other hemostatic problems. In: Wallace D J Dubois E L Quismorio F P Klinenberg J R eds. Dubois's lupus erythematosus, third edition. Philadelphia: Lea & Febiger, 1987: 271–80.

Bloom E J Abrams D I Roger G. Lupus anticoagulant in the acquired immunodeficiency syndrome. JAMA 1986; 256: 491–93.

Smith K J Skelton H G James W D . Cutaneous histopathologic findings in ‘Antiphospholipid Syndrome’. Correlation with disease, including human immunodeficiency virus disease. Arch Dermatol 1990; 126: 1176–83.

Bell D A Boss G R Wolfson J. S. Circulating anticoagulant in the procainamide-induced lupus syndrome. Arch Intern Med 1977 137: 1471–73.

Zarrabi M H Zucker S. Miller L F . Immunologic and coagulation disorders in chlorpromazine treated patients. Ann Intern Med 1979; 91: 194–99.

Alarcon-Segovia D. Sanchez-Guerrero J. Primary antiphospholipid syndrome. J Rheumatol 1989; 16: 482–89.

Asherson R A Khamashta M. Ordi-Ros J. . The ‘primary’ antiphospholipid syndrome: Major clinical and serological features. Medicine 1989; 68: 366–75.

Mackworth-Young C G David J. Loizou S. . Primary antiphospholipid syndrome: Features of patients with raised anticardiolipin antibodies and no other disorders. Ann Rheum Dis 1989; 48: 362–67.

Wong K L Chan F Y Lee C. P. Outcome of pregnancy in patient with systemic lupus erythematosus: A prospective study. Arch Intern Med 1991; 15: 269–73.

Wong R W S Chan J K H Wong K. L. Lupus anticoagulant – a double misnomer. Asian Pac J Allergy Immunol 1987; vmr-5: 161–66.

Mueh J R Herbst K D Rapaport S. I. Thrombosis in patients with the lupus anticoagulant. Ann Intern Med 1980; 92: 156–59.

Boey M L Colaco C B Gharavi A E . Thrombosis in systemic lupus erythematosus: Striking association with the presence of circulating lupus anticoagulant. Br Med J 1983; 287: 1021–23.

Harris E N Gharavi A E Hughes G. R. V. Antiphospholipid antibodies. Clin Rheum Dis 1985; 11: 591–609.

Asherson R A Baguley E. Pal C. Hughes G. R. V. Antiphospholipid syndrome: Five year follow up. Ann Rheum Dis 1991; 50: 805–10.

Rosove M H Brewer P. M. C. Antiphospholipid thrombosis: Clinical course after the first thrombotic event in 70 patients. Ann Intern Med 1992; 117: 303–308.

Asherson R A Higenbottam T W Xuan Dinh A T Khamashta M A Hughes G. R. Pulmonary hypertension in a lupus clinic: Experience with twenty-four patients. J Rheumatol 1990; 17: 1292–98.

Hall S. Buettner H. Harrinder L. S. Occlusive retinal vascular disease in systemic lupus erythematosus. J Rheumatol 1984; 11: 846–50.

Farrant J M Judge M. Thompson R. P. M. Thrombotic cutaneous nodules and hepatic vein thrombosis in the anticardiolipin syndrome. Clin Exp Dermatol 1989; 14: 306–308.

Asherson R A Lanham J G Hull R G . Renal vein thrombosis in systemic lupus erythematosus associated with the ‘lupus anticoagulanty’. Clin Exp Rheumatol 1984; 2: 75–79.

Levine S R Deagan M J Futrell N. Welch K. M. A. Cerebrovascular and neurologic disease associated with antiphospholipid antibodies: 48 cases. Neurology 1990; 40: 1181–89.

The Antiphospholipid Antibodies in Stroke Study Group. Clinical and laboratory findings in patients with antiphospholipid antibodies and cerebral ischaemia. Stroke 1990; 21: 1268–73.

Briley D P Coull B M Goodnight S. H. Neurological disease associated with antiphospholipid antibodies. Ann Neurol 1989; 25: 211–17.

Kleiner R C Najarain L V Schatten S. Jabs D A Patz A. Kaplan H. J. Vaso-occlusive retinopathy associated with antiphospholipid antibodies (lupus anticoagulant retinopathy). Ophthalmology 1989; 96: 896–904.

Inzelberg R. Korczyn A. D. Lupus anticoagulant and late onset seizures. Acta Neurol Scand 1989; 79: 114–18.

Coull B M Bourdette D N Goodnight S H Jr Briley D P Hart R. Multiple cerebral infarctions and dementia associated with anticardiolipin antibodies. Stroke 1987; 18: 1107–12.

Khamashta M A Gil A. Anciones B. . Chorea in systemic lupus erythematosus: Association with antiphospholipid antibodies. Ann Rheum Dis 1988; 47: 681–83.

Lavalle C. Pizarro S. Drenkard C. Sanchez-Guerrero J. Alarcon-Segovia D. Transverse myelitis: A manifestation of systemic lupus erythematosus strongly associated with antiphospholipid antibodies. J Rheumatol 1990; 17: 34–37.

Hamsten A. Norberg R. Bjorkholm M. . Antibodies to cardiolipin in young survivors of myocardial infarction: An association with recurrent cardiovascular events. Lancet 1986; 1: 113–15.

Inam S. Sidki K. Al-Marshedy A-R Judzewitsch R. Addison's disease, hypertension, renal and hepatic microthrombosis in ‘primary’ antiphospholipid syndrome. Postgrad Med J 1991; 67: 385–88.

Ostuni P A Lazzarin P. Pengo V. Ruffatti A. Schiavon F. Gambari P. Renal artery thrombosis and hypertension in a 13 year old girl with antiphospholipid syndrome. Ann Rheum Dis 1990; 49: 184–87.

Kant K S Pollack V E Weiss M A Glueck H I Miller A N Hess E. V. Glomerular thrombosis in systemic lupus erythematosus: Prevalence and significance. Medicine 1981; 60: 71–86.

Frampton G. Hicks J. Cameron J. S. Significance of antiphospholipid antibodies in patients with lupus nephritis. Kidney Int 1991; 39: 1225–31.

Hughson M D Nadasdy T. McCarty G A Sholer C. Min K W Silva F. Renal thrombotic microangiopathy in patients with systemic lupus erythematosus and the antiphospholipid syndrome. Am J Kidney Dis 1992; 20: 150–58.

Garcia-Martin F. De Arriba G. Carrascosa T. . Anticardiolipin antibodies and lupus anticoagulant in end-stage renal disease. Nephrol Dial Transplant 1991; 6: 543–47.

Branch W D Scott J T Kochenour N K Hershgold E. Obstetric complications associated with the lupus anticoagulant. N Engl J Med 1985; 313: 1322–26.

Lockshin M D Druzin M L Goei S. . Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with systemic lupus erythematosus. N Engl J Med 1985; 313: 152–56.

Cowchock S. Smith J R Gocial B. Antibodies to phospholipid and nuclear antigens in patients with repeated abortions. Am J Obstet Gynecol 1986; 155: 1002–10.

McNeil H P Chesterman C N Krills S. A. Immunology and clinical importance of antiphospholipid antibodies. In: Duluth D R ed. Advances in immunology. London: Academic Press, 1991: 193–280.

Lubbe W F Pattison N. Liggins G. C. Antiphospholipid antibodies and pregnancy (letter). N Engl J Med 1985; 313: 1350.

Carreras L O Vermylen J. G. ‘Lupus’ anticoagulant and thrombosis – possible role of inhibition of prostacyclin formation. Thromb Haemost 1982; 48: 28–40.

Branch D W Andres R. Digre I C B Rote N S Scott J. R. The association of antiphospholipid antibodies with severe preeclampsia. Obstet Gynecol 1989; 73: 54–55.

Harris E N Asherson R A Gharavi A E . Thrombocytopenia in SLE and related autoimmune disorders association with anticardiolipin antibodies. Br J Haematol 1985; 59: 227–30.

Murphy J J Leach I. A. Findings at necropy in the heart of a patient with anticardiolipin syndrome. Br Heart J 1989; 62: 61–64.

Leung W H Wong K L Lau C P Wong C K Liu H. W. Association between antiphospholipid antibodies and cardiac abnormalities in patients with systemic lupus erythematosus. Am J Med 1990; 89: 411–19.

Chartash E K Lans D M Paget S A Qamar T. Lockshin M. D. Aortic insufficiency and mitral regurgitation in patients with systemic lupus erythematosus and the antiphospholipid syndrome. Am J Med 1989; 86: 407–12.

Ford P H Ford S E Lillierap D. P. Association of lupus anticoagulant with severe valvular heart disease in SLE. J Rheumatol 1988; 15: 597–600.

Alegre V A Gastineau D A Winkelmann R. K. Skin lesions associated with circulating lupus anticoagulant. Br J Dermatol 1989; 120: 419–29.

Harris E N Gharavi A E Mackworth-Young C G Patel B M Derue G. Hughes G. R. V. Lupoid sclerosis: A possible genetic role for antiphospholipid antibodies. Ann Rheum Dis 1985; 44: 281–83.

Meyer O. Piette J V C Bourgeois P. . Antiphospholipid antibodies – a disease marker in 25 patients with antinuclear antibody negative systemic lupus erythematosus (SLE) – comparison with a group of 91 patients with antinuclear antibody positive SLE. J Rheumatol 1987; 14: 502–506.

Derksen R H W M Hasselaar P. Blokzil L. Meyling F H J G De Groot P. G. Coagulation screen is more specific than the anticardiolipin antibody ELISA in defining a thrombotic subset of lupus patients. Ann Rheum Dis 1988; 47: 364–71.

Triplett D A Brandt J. T. Lupus anticoagulant: Misnomer, paradox, riddle, epiphenomenon. Haematol Pathol 1988; 2: 121–43.

MacFarlane R. G. An enzyme cascade in the blood clotting mechanism and its function as a biochemical amplifier. Nature 1964; 202: 498–99.

Brandt J T Triplett D A Musgrave K. Orr C. The sensitivity of different coagulation reagents to the presence of lupus anticoagulants. Arch Pathol Lab Med 1987; 111: 120–24.

Green D. Hougie C. Kazmier F J . Report on the working party on acquired inhibitors of coagulation: Studies of the ‘lupus’ anticoagulant. Thromb Haemost 1983; 49 (2): 144–46.

Exner T. Richard K A Kronenberg B. H. A sensitive test demonstrating lupus anticoagulant and its behavioral patterns. Br J Haematol 1978; 40: 143–51.

Lo S C L Oldmeadow M J Howard M A Firkin B. G. Comparison of laboratory tests used for identification of the lupus anticoagulant. Am J Hematol 1989; 30: 213–20.

Triplett D A Brandt J T Kaczor D. Schaeffer J. Laboratory diagnosis of lupus inhibitors: A comparison of the tissue thromboplastin inhibition procedure with a new platelet neutralization procedure. Am J Clin Pathol 1983; 79: 678–82.

Khamashta M A Hughes G. R. V. Detection and importance of anticardiolipin antibodies. J Clin Pathol 1993; 46: 104–107.

Gharavi A. E. Antiphospholipid cofactor. Stroke 1992; 23 (suppl): 7–10.

Asherson R A Derksen R H W M Harris E N . Large vessel occlusion and gangrene in SLE and ‘lupus like’ disease. A report of 6 cases. J Rheumatol 1986; 13: 740–47.

Kaiser L. Sparks H V Jr . Endothelial cells. Not just a cellophane wrapper. Arch Intern Med 1987; 147: 569–73.

Hasselaar P. Derksen R H W M Blokzijl L. De Groot P. G. Crossreactivity of antibodies directed against cardiolipin, DNA, endothelial cells and blood platelet. Throm Haemost 1990; 63: 169–73.

Moncada S. Higgs E A Vane J. R. Human arterial and venous tissue generate inhibitor of platelet aggregation. Lancet 1977; 1: 18–21.

Rustin M H Bull H A Machin S J Isenberg D A Snaith M L Dowd P. M. Effects of the lupus anticoagulant in patients with systemic lupus erythematosus on endothelial cell prostacyclin release and procoagulant activity. J Invest Dermatol 1988; 90: 744–48.

Hasselaar P. Derksen R H W M Blokzijl L. De Groot P. G. Thrombosis associated with antiphospholipid antibodies cannot be explained by effects on endothelial and platelet prostanoid synthesis. Thromb Haemost 1988; 59: 80–85.

Schinco P C Marranca D. Bazzan M. . Lupus anticoagulant: Interference with in vivo prostaglandin production and with platelet sensitivity to prostacyclin. Scand J Rheumatol 1992; 21: 124–28.

Walker T S Triplett D A Javed N. Musgrave K. Evaluation of lupus anticoagulants: Antiphospholipid antibodies, endothelium associated immunoglobulin, endothelial prostacyclin secretion, an antigenic protein S levels. Thromb Res 1988; 51: 267–81.

Watson K V Schorer A. E. Lupus anticoagulant inhibition of in vitro prostacyclin release is associated with a thrombosis-prone subset of patients. Am J Med 1991; 90: 47–53.

Angles-Cano E. Sultan Y. Clauvell J. P. Predisposing factors to thrombosis in systemic lupus erythematosus. J Lab Clin Med 1979; 94: 312–23.

Francis R B Jr Neely S. Effect of the lupus anticoagulant on endothelial fibronolytic activity in vitro. Thromb Haemost 1989; 61: 314–17.

Francis R B Jr McGehee W G Feinstein D. I. Endothelial-dependent fibrinolysis in subjects with the lupus anticoagulant and thrombosis. Thromb Haemost 1988; 59: 412–14.

Tsakiris D A Marbet G A Makris P E Settas L. Duckert F. Impaired fibrinolysis as an essential contribution to thrombosis in patients with lupus anticoagulant. Thromb Haemost 1989; 61: 175–77.

Esmon E. T. The regulation of natural anti-coagulant pathways. Science 1987; 235: 1348–52.

Comp P C DeBault L E Esmon N L Esmon C. T. Human thrombomodulin is inhibited by IgG from two patients with non-specific anticoagulants. Blood 1983; 62: 299a.

Cariou R. Tobelem G. Bellucci S. . Effect of lupus anti-coagulant on antithrombogenic properties of endothelial cells: Inhibition of thrombomodulin-dependent protein C activation. Thromb Haemost 1988; 60: 54–58.

Marciniak E. Romond E. H. Impaired catalytic function of activated protein C: A new in vitro manifestation of lupus anticoagulant. Blood 1989; 74: 2426–32.

Lo S C Salem H H Howard M A Oldmeadow M J Firkin B. G. Studies of the natural anticoagulant proteins and anticardiolipin antibodies in patients with the lupus anticoagulant. Br J Haematol 1990; 76: 380–86.

Tsakaris D A Settas L. Makris P E Marbet G. A. Lupus anticoagulant-antiphospholipid antibodies and thrombophilia. Relation to protein C–Protein S–thrombomodulin. J Rheumatol 1990; 17: 785–89.

Stankiewicz A J Steiner M. Lally E V Kaplan S. R. Abnormally high levels of C4b binding protein and deficiency of free fraction of protein S in a patient with systemic lupus erythematosus and recent thromboses. J Rheumatol 1991; 18: 82–87.

Ruiz-Arguelles G J Ruiz-Arguelles A. Alarcon-Segovia D. . Natural anticoagulants in systemic lupus erythematosus: Deficiency of protein S bound to C4bp associates with recent history of venous thrombosis, antiphospholipid antibodies, and the antiphospholipid syndrome. J Rheumatol 1991; 18: 552–58.

Marcus A J McKenny J B Rosenberg R. D. The acceleration of thrombin–antithrombim complex formation in rat hindquarters via naturally occurring heparin-like molecules bound to the endothelium. J Clin Invest 1984; 74: 341–50.

Cosgriff T M Martin B. A. Low functional and high antigenic antithrombin III level in a patient with the lupus anticoagulant and recurrent thrombosis. Arthritis Rheum 1987; 24: 94–95.

Mayumi T. Nagasawa K. Inogucai T. . Haemostatic factors associated with vascular thrombosis in patients wtih systemic lupus erythematosus and the lupus anticoagulant. Ann Rheum Dis 1991; 50: 543–47.

Galli M. Cortelazzo S. Viero P. Finazzi G. De Gaetano G. Barbui T. Interaction between platelet and lupus anticoagulant. Eur J Haematol 1988; 41: 88–94.

Lellouche F. Martinuzzo M. Said P. Maclouf J. Carreras L. O. Imbalance of thromboxane/prostacyclin biosynthesis in patients with lupus anticoagulant. Blood 1991; 78: 2894–99.

Sanfelippo M J Drayna C. J. Prekallikren inhibition associated with the lupus anticoagulant. Am J Clin Pathol 1982; 77: 275–79.

Galli M. Beguin S. Lindhout T. Hemker C. H. Inhibition of phospholipid and platelet-dependent prothrombinase activity in the plasma of patients with lupus anticoagulants. Br J Haematol 1989; 72: 549–55.

Santiago M B Gaburo N. Jr De Oliveira R M Crossermelli W. Complement activation by cardiolipin antibodies. Ann Rheum Dis 1991; 50: 249–50.

Lubbe W F Butler W S Palmer S J Liggins G. C. Fetal survival after prednisone suppression of maternal lupus anticoagulant. Lancet 1983; 1: 1361–63.

Ordi J. Barquinero J. Vilardell M. . Fetal loss treatment in patients with antiphospholipid antibodies. Ann Rheum Dis 1989; 48: 798–802.

Lockshin M D Druzin M L Qamar T. Prednisone does not prevent recurrent fetal death in women with antiphospholipid antibody. Am J Obstet Gynecol 1989; 160: 439–43.

Simel D L St Clair E W Adams J. Greenberg C. S. Correction of hypoprothrombinaemia by immunosuppressive treatment of the lupus anticoagulant-hypoprothrombinaemia syndrome. Am J Med 1987; 83: 563–66.

Sturfelt G. Nived O. Norberg R. Thorstensson R. Krook K. Anticardiolipin antibodies in patients with systemic lupus erythematosus. Arthritis Rheum 1987; 30: 382–88.

Ingram S B Goodnight S H Bennet R. M. An unusual syndrome of a devastating noninflammatory vasculopathy associated with anticardiolipin antibodies. Report of two cases. Arthritis Rheum 1987; 30: 1167–72.

Parke A. The role of IVIG in the management of patients with antiphospholipid antibodies and recurrent pregnancy losses. Clin Rev Allergy 1992; 10: 105–18.

Kobayashi S. Tamura N. Tsuda H. Mokuno C. Hashimoto H. Hirose S. Immunoadsorbent plasmapheresis for a patient with antiphospholipid syndrome during pregnancy. Ann Rheum Dis 1992; 51: 399–401.

Joffe A M Hoskins C F Ghitter-Mannes S C Mart M. J. Anticoagulant therapy for prevention of spontaneous abortion in a patient with a lupus anticoagulant. Am J Hematol 1988; 29: 56–57.

Asherson R A Chan J K H Harris E N Gharavi A E Hughes G. R. V. Anticardiolipin antibody, recurrent thrombosis and warfarin withdrawal. Ann Rheum Dis 1985; 44: 823–25.

Moreb J. Kitchens C. S. Acquired functional protein S deficiency, cerebral venous thrombosis, and courmarin skin necrosis in association with antiphospholipid syndrome: Report of two cases. Am J Med 1989; 87: 207–10.

Cowchock F S Reece E A Balaban D. Branch D W Plouffe L. Repeated fetal losses associated with antiphospholipid antibodies: A collaborative randomized trial comparing prednisone with low-dose heparin treatment. Am J Obstet Gynecol 1992; 166: 1318–23.

Tabachnik-Schor N F Lipton S. A. Association of lupus like anticoagulant and nonvasculitic cerebral infarction. Arch Neurol 1986; 43: 851–52.

Digre K B Durcan F J Branch D W Jacobson D M Varner M W Baringer J. R. Amaurosis fugax associated with antiphospholipid antibodies. Ann Neurol 1989; 25: 228–32.