Chromosome 19 locus apolipoprotein C-II association with multiple sclerosis

Abstract

We have used a PCR based method to analyze allelic frequencies in a (TG)_n(AG)_m microsatellite marker located in the first intron of the apolipoprotein C-II gene in French MS patients and controls. Samples were collected from 74 MS patients and from 102 controls. The distribution of microsatellite alleles differed between patients and controls (w²=7.82), showing a significant effect (P50.04) with MS due to the increased frequency of the allele 6 and a decrease frequency (P50.03) of allele 1. Our study confirms that the apolipoprotein C-II region may influence susceptibility to MS.

Keywords

multiple sclerosis (MS)apolipoprotein C-II gene microsatellite allelic frequencies genetic susceptibility chromosome 19q13.2 region

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References

Ebers GC , Sadovnick AD , Risch NJ. (1995) A genetic basis for familial aggregation in multiple sclerosis . Nature 377: 150-151 .

Allen M et al. (1994) Association of susceptibility to multiple sclerosis in Sweden with HLA class II DRB1 and DQB1 . Hum Immunol 39: 41-48 .

Ebers GC et al. (1996) A full genome search in multiple sclerosis . Nat Genet 13: 472-476 .

Haines JL et al. (1996) A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex . Nat Genet 13: 469-471 .

Sawcer S et al. (1996) A genome screen in multiple sclerosis reveals susceptibility loci on chromosomes 6p21 and 17q22 . Nat Genet 13: 464-468 .

Haines JL et al. (1994) Genetic dissection of the multiple sclerosis genotype . Am J Hum Genet 53: A266-A266 (Abstract).

Formage M , Chan L , Siest G , Boerwinkle E. (1992) Allele frequency distribution of the (TG)n(AG)m microsatellite in the apolipoprotein C-II gene . Genomics 12: 63-68 .

Poser CM et al. (1983) New diagnostic criteria for multiple sclerosis: guidelines for research protocols . Ann Neurol 13: 227-231 .

Risch N , Merikangas K. (1996) The future of genetic studies of complex human diseases . Science 273: 1516-1517 .

10.

Ashworth LK et al. (1995) An integrated metric physical map of human chromosome 19 . Nat Genet 11: 422-427 .

11.

Kamboh MI. (1995) Apolipoprotein E polymorphism and susceptibility to Alzheimer's disease . Hum Biol 67: 195-215 .

12.

Rubinstein DC et al. (1994) ApoE genotypes in multiple sclerosis, Parkinson's disease, schwannomas and late-onset Alzheimer's disease . Mol Cell Probes 8: 519-525 .

13.

Allan CM , Walker D , Segrest JP , Taylor JM. (1995) Identification and characterization of a new human gene (APOC4)inthe apolipoprotein E, C1, and C2 gene locus . Genomics 28: 291-300 .