Side effect profile and adherence to in the treatment of Multiple Sclerosis with interferon beta-la

Abstract

This study examines the course of patient-reported side effect during the first 4 months of treatment for multiple sclerosis (MS) with interferon beta-Ia (IFNβ-Ia), and the relationship of those side effects to discontinuation of medication. Flu-like symptoms, muscle aches and chills decreased over the first 2 months of treatment but did not change over the second 2 months. Loss of feeling or numbness, tingling and depression increased over 4 months, however these side effects were generally mild. Loss of feeling or numbness and tingling at 2 month follow-up were significantly related to discontinuation of IFNβ-Ia by 4 month follow-up.