The effect of cross-talk on MRI lesion numbers and volumes in multiple sclerosis using conventional and turbo spin-echo

Abstract

We measured and compared lesion numbers and volumes present on brain magnetic resonance imaging (MRI) scans of patients with multiple sclerosis (MS) acquired with contiguous (scheme A) and interleaved (scheme B) slice acquisition, to evaluate whether there was a gain in sensitivity using the second pattern of acquisition and whether this counterbalanced the doubled acquisition time. Conventional spin-echo (CSE) sequences were performed for eight patient and turbo spin-echo (TSE) sequences for ten. Acquisition scheme B detected 3.8% more lesions than acquisition scheme A (the increase was 3. 1% for CSE and 4.5% for TSE). These differences were not statistically significant. No significant difference in lesion numbers was found when different lesion locations were also considered. Lesion volumes were significantly higher when scheme B was used (P=0.024). This was due to higher lesion volumes on TSE images (P=0.006), especially on even-numbered slices (P=0.008). Inter-slice cross-talk has a negligible effect on lesion numbers and volume estimates in MS for CSE sequence, whilst it cannot be neglected when TSE sequences are used to measure MS lesion volume.

Keywords

multiple sclerosis magnetic resonance imaging cross-talk lesion volumes

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References

Filippi M , Horsfield MA , Bressi S , Martinelli V , et al. (1995) Intra- and inter-observer variability of brain MRI lesion volume measurements in multiple sclerosis: a comparison of techniques . Brain 118: 1593-1600 .

Filippi M , Horsfield MA , Campi A , Mammi S , et al. (1995) Resolution-dependent estimates of lesion volumes in MRI studies of the brain in multiple sclerosis . Ann Neurol 38: 749-754 .

Filippi M , Horsfield MA , Tofts PS , Barkhof F et al. (1995) Quantitative assessment of MRI lesion load in monitoring the evolution of multiple sclerosis . Brain 118: 1601-1612 .

Filippi M , Paty DW , Kappos L , Barkhof F et al. (1995) Correlations between changes in disability and T2- weighted brain MRI activity in multiple sclerosis: a follow up study . Neurology 45: 255-260 .

Filippi M , van Waesberghe JH , Horsfield MA , Bressi S et al. (1997) Interscanner variation in brain MIRI lesion load measurements in MS: implications for clinical trials . Neurology 49: 371-377 .

Filippi M , Yousry T , Baratti C , Horsfield MA et al. (1996) Quantitative assessment of MRI lesion load in multiple sclerosis: a comparison of conventional spin-echo with fast-fluid-attenuated inversion recovery . Brain 119: 1349-1355 .

Gass A , Barker GJ , Kidd D , Thorpe JW et al. (1994) Correlation of magnetization transfer ratio with disability in multiple sclerosis . Ann Neurol 36: 62-67 .

Grimaud J , Lai M , Thorpe JW , Adeleine P et al. (1996) Quantification of MRI lesion load in multiple sclerosis: a comparison of three computer-assisted techniques . Magn Reson Imaging 5: 495-505 .

Kurtze JE. (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS) . Neurology 33: 1444-1452 .

10.

Miller DH , Barkhof F , Berry I , Kappos L et al. (1991). Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines . J Neurol Neurosurg Psychiatry 54: 683-688 .

11.

Miller DH , Albert PS , Barkhof F , Francis G et al. (1996) Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis . Ann Neurol 36: 6-16 .

12.

Miller DH , Barkhof F , Nauta JJP. (1993) Gadolinium enhancement increases the sensitivity of MRI in detecting disease activity in multiple sclerosis . Brain 116: 1077-1094 .

13.

Paty DW , Li DKB , UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group . (1993) Interferon beta-lb is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial . Neurology 43: 662-667 .

14.

Poser CM , Paty DW , Scheinberg L , McDonald WI et al. (1983) New diagnostic criteria for multiple sclerosis: guidelines for research protocols . Ann Neurol 13: 227-231 .

15.

Simmons A , Tofts PS , Barker GJ , Arridge SR. (1994) Sources of intensity nonuniformity in spin-echo images at 1.5 T . Magn Reson Med 32: 121-128 .

16.

Thorpe JW , Halpin SF , Macmanus DG , Barker GJ et al. (1994) A comparison between fast and conventional spin-echo in the detection of multiple sclerosis lesions . Neuroradiology 36: 388-392 .

17.

van Walderveen MAA , Barkhof F , Hommes OR , Polman CH et al. (1995) Correlating MR imaging and clinical disease activity in multiple sclerosis: relevance of hypointense lesions on short TR/short TE ('Tl-weighted') spin-echo images . Neurology 45: 1684-1690 .