Computerized color perimetry in multiple sclerosis

Abstract

Color visual field analysis has proven highly sensitive for early visual impairments diagnosis in MS, yet it has never attained widespread popularity usually because the procedure is difficult to standardize, the devices are costly, and the test is fatiguing. We propose a computerized procedure running on standard PC, cost effective, clonable, and easy handled. Two hundred and sixty-four colored patches subtending 18 angle of vision, with selected hues and low saturation levels are sequentially and randomly displayed on gray equiluminous background of the PC screen subtending 2486408 angle of vision. The subject is requested to press a switch at the perception of the stimulus. The output provides colored maps with quantitative information. Comparison between normals and a selected population of MS patients with no actual luminance visual field defects, showed high statistical difference.

Keywords

automatic perimetry color perimetry color defects in multiple sclerosis

Get full access to this article

View all access options for this article.

References

Fallowfield L , Krauskopt J. (1984) Selective loss of chromatic sensitivity in demyelinating disease . Invest Ophthalmol Vis Sci 25: 771-773 .

Flammer J , Drance SM. (1984) Correlation between color vision scores and quantitative perimetry in suspected glaucoma . Arch Ophthalmol 102: 38-39 .

Chioran GM et al. (1985) Color mixture threshold measured on a color television-a new method for analysis, classification and diagnosis of neuroophthalmic disease . Doc Ophthalmol 61: 119-135 .

Gunduz K et al. (1988) Color vision defects in ocular hypertension and glaucoma. Quantification with a computer-driven color television system . Arch Ophthalmol 106: 929-935 .

Vingrys AJ , Ewen King-Smith P , Benes SC. (1989) Color perimetry can be more sensitive than achromatic perimetry . Clin Vision Sci 4: 197-209 .

Berninger TA , Jaeger W , Krastel H. (1991) Electrophysiology and colour perimetry in dominant infantile optic atrophy . Br J Ophthalmol 75: 49-52 .

Kulikowski JJ , Metcalf RA , Murray IJ , Russel MHA. (1991) The visual defect in multiple sclerosis and optic neuritis . Oxford University Press 114 2419-2435 .

Mutlukan E , Cullen JF. (1991) Red colour comparison perimetry chart in neuro-ophthalmological examination . Eye 5: 352-361 .

Johnson CA , Adams AJ , Casson EJ , Brandt JD. (1993) Blue-on-yellow perimetry can predict the development of glaucomatous visual field loss . Arch Ophthalmol 111: 645-650 .

10.

Nagy AL , Wolf S. (1993) Red-green color discrimination in peripheral vision . Vision Res 33: 235-242 .

11.

Keltner JL , Johnson CA , Spurr JO , Beck RW. (1994) Visual field profile of optic neuritis: One-year follow-up in the optic neuritis treatment trial . Arch Ophthalmol 112: 946-953 .

12.

Phillips ML et al. (1994) Optic neuritis. Differential losses of luminance and chromatic function near a scotoma . Brain 117: 767-773 .

13.

Accornero N , Berardelli A , Cruccu G , Manfredi M. (1984) Computerized video screen perimetry . Arch Ophthalmol 102: 40-41 .

14.

Filligoi GC , Capitanio L , Accornero N. (1991) Automatic visual field: A software diagnostic procedure . Comp Methods Progr Biomed 38: 49-59 .

15.

Accornero N , Capozza M. (1995) OPTONET: neural network for visual field diagnosis . Med Biol Eng Comput 33: 223-226 .

16.

Macaluso C , Lamedica A , Baratta G , Cordella M. (1996) Color discriminant along the cardinal chromatic axes with VECPs as an index of function of the parvocellular pathway. Correspondence of intersubject and axis variations to psychophysics . Electroenceph Clin Neurophysiol 100: 12-17 .

17.

Porciatti V , Sartucci F. (1996) Retinal and cortical evoked responses to chromatic contrast stimuli. Specific losses in both eyes of patients with multiple sclerosis and unilateral optic neuritis . Brain 119: 723-740 .

18.

Perkin GD , Rose FC. (1979). Optic neuritis and its differential diagnosis. Oxford: Oxford University Press .

19.

Comi G et al. (1993). Brainstem magnetic resonance imaging and evoked potential studies of symptomatic multiple sclerosis patients . Eur Neurol 33: 232-237 .

20.

Thompson P , Travis D. (1989) Spatiotemporal contrast sensitivity and colour vision in multiple sclerosis . Oxford University Press 112: 283-303 .