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Abstract

Brain proteins are released into body fluids in a fashion which reflects the underlying pathogenetic mechanisms for individual diseases. It is therefore important to distinguish not only different protein markers (reflecting various brain cells from which they have been released), but also their metabolism at different sites within the body (e.g. reticulo-endothelial system vs renal clearance) which will have an important bearing on whether fragments of the protein are found in urine or blood. It is clear that different patterns of protein abnormalities would be helpful in differential diagnosis of the individual diseases which afflict the nervous system. It would also be useful to monitor these proteins either as surrogate markers of the natural history of the condition or in the various therapies for each disease.

Keywords

brain-specific proteins Creutzfeldt-Jakob disease myelin basic protein neurone-specific enolase S-100 spinal fluid

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References

Moore BW , McGregor D. (1965) Chromatographic and electrophoretic fractionation of soluble proteins of brain and liver . J Biol Chem 240: 1647-1753 .

Jimi T et al. (1992) High levels of nervous system-specific proteins in cerebrospinal fluid in patients with early stage Creutzfeldt-Jakob disease . Clin Chim Acta 211: 37-46 .

Hans P , Born JD , Albert A. (1987) `Extrapolated' creatine kinase-BB isoenzyme activity in assessment of initial brain damage after severe head injury . JNeurosurg 66: 714-717 .

Schaarschmidt H , Prange HW , Reiber H. (1994) Neuron-specific enolase concentrations in blood as a prognostic parameter in cerebrovascular diseases . Stroke 25: 558-565 .

Thomas DGT , Palfreyman JW , Ratcliffe JG. (1978) Serum myelin basic protein assay in diagnosis and prognosis of patients with head injury . Lancet i: 113-115 .

Whitaker JN et al. (1993) Correlation of myelin basic protein-like material in cerebrospinal fluid of multiple sclerosis patients with their response to glucocorticoid treatment . Ann Neurol 33: 10-17 .

Revesz T et al. (1994) A comparison of the pathology of primary and secondary progressive multiple sclerosis . Brain 117: 759-765 .

Lamers KJB et al. (1995) Cerebrospinal neuron-specific enolase, S-100 and myelin basic protein in neurological disorders . Acta Neurol Scand 92: 247-251 .

Whitaker JN et al. (1994) Correlation of clinical features and findings on cranial magnetic resonance imaging with urinary myelin basic protein-like material in patients with multiple sclerosis . Ann Neurol 35: 577-585 .

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Missler U , Wandinger P , Wiesmann M , Wessel K. (1996) Elevated plasma concentrations of S-100 protein indicate acute exacerbation of multiple sclerosis . 69th German Neurological Congress Göttingen. Abs.

Protein markers of brain damage

Abstract

Keywords

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