An Uhthoff-like phenomenon was recently observed in a patient with clinically definite MS who experienced transient dysphonia brought on by exertion and relieved by cooling. The patient's dysphonia was felt to be related to intermittent temperature-dependent conduction block associated with a demyelinating plaque in the region of the left nucleus ambiguus. We have termed the patient's intermittent dysphonia ‘laryngeal Uhthoffs phenomenon'.
1 Uhthoff W. (1890) Untersuchungen über die bei der multiplen herdsklerose vorkommenden augenstorungen. Arch Psychiatr Nerv Krankh21: 55–116, 303–410.
2.
2 Young GA, Bennet AE. (1927) Nonspecific protein (typhoid vaccine) therapy of disseminated sclerosis. Nebr St Med J12: 401–406.
3.
3 McAlpine D, Compston N. (1952) Some aspects of the natural history of disseminated sclerosis. Q J Med21: 135–167.
4.
4 Guthrie TC. (1951) Visual and motor changes in patients with multiple sclerosis. A result of induced changes in environmental temperature. Arch Neurol Psychiatr Chicago65: 437–451.
5.
5 Davis FA. (1970) Axonal conduction studies based on some considerations of temperature effects in multiple sclerosis. Electroencephalogr Clin Neurophysiol28: 281–286.
6.
6 Schauf CL, Davis FA. (1974) Impulse conduction in multiple sclerosis: a theoretical basis for modification by temperature and pharmacological agents. J Neurol Neurosurg Psychiatr37: 152–161.