Paramagnetic rim lesions on 7T MRI after autologous hematopoietic cell transplantation

Abstract

Background:

Compared to the potent efficacy of autologous hematopoietic cell transplantation (AutoHCT) on multiple sclerosis (MS) lesion activity, benefit on disability progression is less clear. Paramagnetic rim lesions (PRLs) are imaging biomarkers associated with progression.

Objectives:

Evaluate effect of AutoHCT on PRLs using 7T magnetic resonance imaging (MRI).

Methods:

A single rater evaluated PRLs before/after AutoHCT on 7T MRI at an MS referral center.

Results:

Seven participants were included with mean age 38.9 years and median disease duration 9 years. Median PRL count pre-transplantation was 2. Post-AutoHCT (median 15 months in 5 participants) none of the PRLs resolved.

Conclusion:

These results provide low-level evidence that PRLs do not resolve following AutoHCT.