Certain prion diseases have been observed to exhibit positive oligoclonal bands (OCBs), a key marker in diagnosing multiple sclerosis (MS).
Methods:
We describe a case of Gerstmann–Sträussler–Scheinker (GSS) disease presenting with positive OCBs, no sustained abnormalities in the cortex or basal ganglia, and limited brain atrophy progression, mimicking the clinical profile of primary progressive MS (PPMS).
Conclusion:
Atypical white matter findings and warning signs should prompt caution in diagnosing MS. GSS should be recognized as a potential differential diagnosis for PPMS.
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