Severe hypertriglyceridemia associated with teriflunomide in a patient with multiple sclerosis: A case report

Abstract

Objective:

To describe a case of severe hypertriglyceridemia in a patient receiving teriflunomide.

Methods:

This is a case study.

Results:

Our patient developed severe hypertriglyceridemia (>5000 mg/dL) while on teriflunomide. The drug was withdrawn. Resolution began over 3 weeks later.

Conclusion:

We describe the first probable case of teriflunomide-associated severe hypertriglyceridemia in a patient with multiple sclerosis, an adverse event previously associated with leflunomide in patients with rheumatologic diseases. Clinicians should be aware of this rare but potentially dangerous adverse event.