Radiologically isolated syndrome should be treated with disease-modifying therapy

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Polman

Reingold

Banwell

et al . Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011; 69: 292–302.

Okuda

. Unanticipated demyelinating pathology of the CNS. Nat Rev Neurol 2009; 5: 591–597.

Sati

Constable

et al . The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: A consensus statement from the North American imaging in multiple sclerosis cooperative. Nat Rev Neurol 2016; 12: 714–722.

Newton

Wright

Winkler

et al . Three-dimensional shape and surface features distinguish multiple sclerosis lesions from nonspecific white matter disease. J Neuroimaging. Epub ahead of print 10 May 2017. DOI: 10.1111/jon.12449.

Trapp

Peterson

Ransohoff

et al . Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998; 338: 278–285.

Fisniku

Brex

Altmann

et al . Disability and T2 MRI lesions: A 20-year follow-up of patients with relapse onset of multiple sclerosis. Brain 2008; 131: 808–817.

Azevedo

Overton

Khadka

et al . Early CNS neurodegeneration in radiologically isolated syndrome. Neurol Neuroimmunol Neuroinflamm 2015; 2: e102.

Okuda

Siva

Kantarci

et al . Radiologically isolated syndrome: 5-year risk for an initial clinical event. PLoS ONE 2014; 9: e90509.

Kantarci

Lebrun

Siva

et al . Primary progressive multiple sclerosis evolving from radiologically isolated syndrome. Ann Neurol 2016; 79: 288–294.

10.

Okuda

Frenay

Siva

et al . Multi-center, randomized, double-blinded assessment of dimethyl fumarate in extending the time to a first attack in radiologically isolated syndrome (RIS) (ARISE Trial). Neurology 2015; 84: 207.

11.

Frenay

Siva

Kantarci

et al . Multi-center, randomized, double-blinded assessment of teriflunomide in extending the time to a first clinical event in radiologically isolated syndrome (RIS) the TERIS study. Neurology 2017; 88: 359.

12.

Metz

DKB

Traboulsee

et al . Trial of minocycline in a clinically isolated syndrome of multiple sclerosis. N Engl J Med 2017; 376: 2122–2133.

Radiologically isolated syndrome should be treated with disease-modifying therapy – Yes

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