Mesial temporal lobe and subcortical grey matter volumes differentially predict memory across stages of multiple sclerosis

Abstract

Background/Objective:

Memory deficits due to multiple sclerosis (MS) have been variably linked to lower subcortical grey matter (SCGM) and mesial temporal lobe (MTL) volumes. We investigated which is the better predictor and whether this changes across disease stages.

Methods/Results:

Memory was assessed in 315 patients. Magnetic resonance imaging (MRI) measured volumes of total brain, grey matter, white matter, MTL (hippocampus, amygdala) and SCGM (thalamus, caudate). MTL predicted memory in the total sample and in patients with earlier (<10 years) or later (⩾10 years) relapsing disease. SCGM (specifically thalamus) predicted memory in progressive patients.

Conclusions:

Neuroanatomical correlates of memory deficits differ across disease stages.

Keywords

Multiple sclerosis memory speed volumetric MRI hippocampus thalamus

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References

Rao

Leo

Bernardin

et al . Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology 1991; 41: 685–691.

Benedict

Cookfair

Gavett

et al . Validity of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS). J Int Neuropsychol Soc 2006; 12: 549–558.

Benedict

Ramasamy

Munschauer

et al . Memory impairment in multiple sclerosis: Correlation with deep grey matter and mesial temporal atrophy. J Neurol Neurosurgery Psychiatry 2009; 80: 201–206.

Pinter

Khalil

Pichler

et al . Predictive value of different conventional and non-conventional MRI-parameters for specific domains of cognitive function in multiple sclerosis. Neuroimage Clin 2015; 7: 715–720.

Schoonheim

Popescu

Rueda Lopes

et al . Subcortical atrophy and cognition: Sex effects in multiple sclerosis. Neurology 2012; 79: 1754–1761.

Audoin

Zaaraoui

Reuter

et al . Atrophy mainly affects the limbic system and the deep grey matter at the first stage of multiple sclerosis. J Neurol Neurosurgery Psychiatry 2010; 81: 690–695.

Sicotte

Kern

Giesser

et al . Regional hippocampal atrophy in multiple sclerosis. Brain 2008; 131: 1134–1141.

DeLuca

Chelune

Tulsky

et al . Is speed of processing or working memory the primary information processing deficit in multiple sclerosis? J Clin Exp Neuropsychol 2004; 26: 550–562.

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