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Abstract

Background:

Multiple sclerosis is characterized by white matter lesions, which are visualized with conventional T2-weighted magnetic resonance imaging (MRI). Little is known about local metabolic processes preceding the appearance and during the pathological development of new lesions.

Objective:

To identify metabolite changes preceding white matter (WM) lesions and pathological severity of lesions over time.

Methods:

A total of 59 relapsing-remitting multiple sclerosis (MS) patients were scanned four times, with 6-month intervals. Imaging included short-TE magnetic resonance spectroscopic imaging (MRSI) and diffusion tensor imaging (DTI).

Results:

A total of 16 new lesions appeared within the MRSI slab in 12 patients. Glutamate increased (+1.0 mM (+19%), p = 0.039) 12 and 6 months before new lesions appeared. In these areas, the increase in creatine and choline 6 months before until lesion appearance was negatively correlated with radial diffusivity (ρ = −0.73, p = 0.002 and ρ = −0.72, p = 0.002). Increase in creatine also correlated with the increase of axial diffusivity in the same period (ρ = −0.53, p = 0.034). When splitting the lesions into “mild” and “severe” based on radial diffusivity, only mild lesions showed an increase in creatine and choline during lesion formation (p = 0.039 and p = 0.008, respectively).

Conclusion:

Increased glutamate heralded the appearance of new T2-visible WM lesions. In pathologically “mild” lesions, an increase in creatine and choline was found during lesion formation.

Keywords

Multiple sclerosis MRI MRS MRSI DTI metabolite

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Metabolites predict lesion formation and severity in relapsing-remitting multiple sclerosis

Abstract

Background:

Objective:

Methods:

Results:

Conclusion:

Keywords

Get full access to this article

References

Supplementary Material