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Abstract

Background:

Autoimmune hepatitis (AIH) is a rare and chronic inflammatory disorder associated with extrahepatic autoimmune diseases, including, infrequently, multiple sclerosis (MS).

Short Reports:

We report five cases of MS and AIH association. One patient developed AIH while under interferon beta-1b and the remaining while off disease-modifying therapy, although after methylprednisolone bolus in three. All presented a liver biopsy compatible with AIH. Hepatitis resolution was achieved with immunosuppressive treatment, but one patient died after a fulminant hepatitis requiring liver transplant.

Discussion:

A thorough review of published cases supports this clear, although rare, association and a liver biopsy should be considered in AIH suspected cases.

Keywords

Multiple sclerosis autoimmune hepatitis liver biopsy disease-modifying therapy high-dose intravenous steroids

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