Inadequate outcome measures are the biggest impediment to successful clinical trials in progressive MS

Abstract

View all access options for this article.

Bland

. An introduction to medical statistics. 2nd ed. Oxford: Oxford Medical Publications, 1995.

Hobart

Cano

Zajicek

. Rating scales as outcome measures for clinical trials in neurology: Problems, solutions and recommendations. Lancet Neurol 2007; 6: 1094–1105.

Whitaker

McFarland

Rudge

. Outcomes assessment in multiple sclerosis trials: A critical analysis. Mult Scler 1995; 1: 37–47.

Cohen

Reingold

Polman

. Disability outcome measures in multiple sclerosis clinical trials: current status and future prospects. Lancet Neurol 2012; 11: 467–476.

Barkhof

. Brain atrophy measurements should be used to guide therapy monitoring in MS – NO. Mult Scler. 2016; 22: 1524–1526.

Macleod

McLean

Kyriakopoulou

. Risk of bias in reports of in vivo research: A focus for improvement. PLoS Biol 2015; 13(10): e1002273.