HedströmAKOlssonTAlfredssonL. The role of environment and lifestyle in determining the risk of multiple sclerosis. Curr Top Behav Neurosci2015; 26: 87–104, http://www.ncbi.nlm.nih.gov/pubmed/25707369
3.
KleineietfeldMManzelATitzeJ. et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature2103; 496: 518–522.
4.
WuCYosefTThalhamerT. et al. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature2013; 496: 513–517.
BingerKJGebhardtMHeinigM. et al. High salt reduces the activation of IL-4- and IL-13-stimulated macrophages. J Clin Invest2015; 125: 4223–4238.
7.
HernandezALKitzAWuC. et al. Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. J Clin Invest2015; 125: 4212–4222.
8.
FarezMFFiolMPGaitánMI. et al. Sodium intake is associated with increased disease activity in multiple sclerosis. J Neurol Neurosurg Psychiatry2015; 86: 26–31.
9.
McDonaldJGravesJWaldmanA. et al. A case-control study of dietary salt intake in pediatric-onset multiple sclerosis. Mult Scler Relat Disord2016; 6: 87–92.
10.
FitzgeraldKMungerKFreedmanM. et al. Increased sodium intake is not associated with MS activity or progression in BENEFIT. Neurology2016; 86(Suppl. 1): S37.002
11.
MarrieRAHorwitzRI. Emerging effects of comorbidities on multiple sclerosis. Lancet Neurol2010; 9: 820–828.
12.
ConwayDSThompsonNRCohenJA. Influence of hypertension, diabetes, hyperlipemia, and obstructive lung disease on multiple sclerosis disease course. Mult Scler. Epub ahead of print 26May. DOI: 101177/1352458516650512.
13.
MachnikANeuhoferWJantschJ. et al. Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med2009; 15: 545–552.
14.
PlattenMYoussefSHurEM. et al. Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity. Proc Natl Acad Sci USA2009; 106: 14948–14953.
