To compare the frequency and pattern of cognitive impairment (CI) between patients with neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS).
Methods:
A total of 82 NMOSD patients, 58 MS patients, and 45 healthy controls (HCs) underwent a neuropsychological assessment.
Results:
CI was observed in 29% of NMOSD and 50% of MS patients (p < 0.001); CI was considered present if a patient scored lower than the fifth percentile compared with HCs in at least three domains. A lower frequency of CI was consistently found when CI was indicated by at least two failed tests (p < 0.001). MS patients performed worse than did NMOSD patients on verbal learning and verbal and visual memory tests. Levels of education and depression and the interval from disease onset to treatment were associated with a negative influence on cognition in patients with NMOSD.
Conclusion:
CI in patients with NMOSD may be not as common as in patients with MS. MS patients exhibited severe impairment, particularly on learning and memory tests, compared with NMOSD patients. Differential prevalence and patterns of CI between NMOSD and MS patients suggest that the two diseases have different mechanisms of brain injury.
KimHJPaulFLana-PeixotoMA. et al. MRI characteristics of neuromyelitis optica spectrum disorder: An international update. Neurology2015; 84: 1165–1173.
2.
PittockSJLennonVAKreckeK. et al. Brain abnormalities in neuromyelitis optica. Arch Neurol2006; 63: 390–396.
3.
KimSHKimWKookMC. et al. Central nervous system aquaporin-4 autoimmunity presenting with an isolated cerebral abnormality. Mult Scler2012; 18: 1340–1343.
4.
ChiaravallotiNDDeLucaJ. Cognitive impairment in multiple sclerosis. Lancet Neurol2008; 7: 1139–1151.
5.
BlancFNobletVJungB. et al. White matter atrophy and cognitive dysfunctions in neuromyelitis optica. PLoS ONE2012; 7: e33878.
6.
BlancFZephirHLebrunC. et al. Cognitive functions in neuromyelitis optica. Arch Neurol2008; 65: 84–88.
7.
SajiEArakawaMYanagawaK. et al. Cognitive impairment and cortical degeneration in neuromyelitis optica. Ann Neurol2013; 73: 65–76.
8.
VanottiSCoresEVEizaguirreB. et al. Cognitive performance of neuromyelitis optica patients: Comparison with multiple sclerosis. Arq Neuropsiquiatr2013; 71: 357–361.
9.
LiuYWangJDaamsM. et al. Differential pattern of spinal cord and brain atrophy in NMOSD and MS. Neurology2015; 84: 1465–1472.
10.
DuanYLiuYLiangP. et al. Comparison of grey matter atrophy between patients with neuromyelitis optica and multiple sclerosis: A voxel-based morphometry study. Eur J Radiol2012; 81:e110–e114.
11.
LiuYXieTHeY. et al. Cortical thinning correlates with cognitive change in multiple sclerosis but not in neuromyelitis optica. Eur Radiol2014; 24: 2334–2343.
12.
WingerchukDMLennonVAPittockSJ. et al. Revised diagnostic criteria for neuromyelitis optica. Neurology2006; 66: 1485–1489.
13.
WingerchukDMLennonVALucchinettiCF. et al. The spectrum of neuromyelitis optica. Lancet Neurol2007; 6: 805–815.
14.
PolmanCHReingoldSCBanwellB. et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol2011; 69: 292–302.
15.
AhnHJChinJParkA. et al. Seoul Neuropsychological Screening Battery-dementia version (SNSB-D): A useful tool for assessing and monitoring cognitive impairments in dementia patients. J Korean Med Sci2010; 25: 1071–1076.
16.
ShapiroAMBenedictRHSchretlenD. et al. Construct and concurrent validity of the Hopkins Verbal Learning Test-Revised. Clin Neurospychol1999; 13: 348–358.
17.
ShinMSParkSYParkSR. et al. Clinical and empirical applications of the Rey-Osterrieth Complex Figure Test. Nat Protoc2006; 1: 892–899.
18.
BentonAlHamsherKdeS. Multilingual aphasia examination. Iowa City, IA: University of Iowa, 1976.
19.
SmithA. Symbol digit modalities test. Los Angeles, CA: Western Psychological Services, 1991.
20.
GronwallDM. Paced auditory serial-addition task: A measure of recovery from concussion. Percept Mot Skills1977; 44: 367–373.
21.
WechslerD. Wechsler Adult Intelligence Scale–III: Administration and scoring manual. San Antonio, TX: The Psychological Corporation, 1997.
22.
ReutADeloireMCharré-MorinJ. et al. Cognitive impairment differs between primary progressive and relapsing-remitting MS. Neurology2013; 80: 1501–1508.
23.
BarbarottoRLaiaconaMFrosioR. et al. A normative study on visual reaction times and two Stroop colour-word tests. Ital J Neurol Sci1998; 19: 161–170.
24.
SledJGZijdenbosAPEvansAC. A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging1998; 17: 87–97.
25.
CollinsDLNeelinPPetersTM. et al. Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J Comput Assist Tomogr1994; 18: 192–205.
26.
JeonSYoonUParkJS. et al. Fully automated pipeline for quantification and localization of white matter hyperintensity in brain magnetic resonance image. Int J Imaging Syst Technol2011; 21: 193–200.
27.
PattiFAmatoMPTrojanoM. et al. Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: Baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study. Mult Scler2009; 15: 779–788.
28.
RaoSMLeoGJBernardinL. et al. Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology1991; 41: 685–691.
29.
BenedictRHRamasamyDMunschauerF. et al. Memory impairment in multiple sclerosis: Correlation with deep grey matter and mesial temporal atrophy. J Neurol Neurosurg Psychiatry2009; 80: 201–216.
30.
ZhangNLiYJFuY. et al. Cognitive impairment in Chinese neuromyelitis optica. Mult Scler2015; 21: 1839–1846.
31.
Von GlehnFJariusSCavalcanti LiraRP. et al. Structural brain abnormalities are related to retinal nerve fiber layer thinning and disease duration in neuromyelitis optica spectrum disorders. Mult Scler2014; 20: 1189–1197.
32.
PichiecchioATavazziEPoloniG. et al. Advanced magnetic resonance imaging of neuromyelitis optica: A multiparametric approach. Mult Scler2012; 18: 817–824.
33.
Rueda LopesFCDoringTMartinsC. et al. The role of demyelination in neuromyelitis optica damage: Diffusion-tensor MR imaging study. Radiology2012; 263: 235–242.
34.
ChiaravallotiMDDeLucaJMooreNB. et al. Treating learning impairments improves memory performance in multiple sclerosis: A randomized clinical trial. Mult Scler2005; 11: 58–68.
35.
GmeindlLCourtneySM. Deconstructing spatial working memory and attention deficits in multiple sclerosis. Neuropsychology2012; 26: 57–70.
