A recent interest in euphoria in multiple sclerosis (MS) has resulted in a wealth of literature on this topic. However, a marked change in the definition of this symptom appears to have taken place since its first descriptions in the mid-19th century. This short report will demonstrate that the ‘euphoria’ being studied today may not be the same state as that originally observed and described in MS patients and some implications of this possibility are discussed.
FingerS. A happy state of mind: A history of mild elation, denial of disability, optimism, and laughing in multiple sclerosis. Arch Neurol1998; 55: 241–250.
2.
CharcotJM. Lectures 6 through 8. In: SigersonG (trans and ed) Lectures on the diseases of the nervous system delivered at la Salpêtriére. London, England: New Sydenham Society, 1877, pp.157–222.
3.
SurridgeD. An investigation into some psychiatric aspects of multiple sclerosis. Br J Psychiatry1969; 115: 749–764.
4.
CottrellSSWilsonSAK. The affective symptomatology of disseminated sclerosis: A study of 100 cases. J Neurol Psychopathol1926; 7: 1–30.
5.
GhaffarOFeinsteinA. The neuropsychiatry of multiple sclerosis: A review of recent developments. Curr Opin Psychiatry2007; 20: 278–285.
6.
KesselringJKlementU. Cognitive and affective disturbances in multiple sclerosis. J Neurol2001; 248: 180–183.
7.
Diaz-OlavarrietaCCummingsJLVelazquezJ. Neuropsychiatric manifestations of multiple sclerosis. J Neuropsychiatry and Clin Neurosci1999; 11: 51–57.
8.
CummingsJLMegaMGrayK. The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia. Neurology1994; 44: 2308–2314.
9.
CaroneDABenedictRHBMunschauerFE. Interpreting patient/informant discrepancies of reported cognitive symptoms in MS. J Int Neuropsychol Soc2005; 11: 574–583.
10.
BenedictRHBPrioreRLMillerC. Personality disorder in multiple sclerosis correlates with cognitive impairment. J Neuropsychiatry and Clin Neurosci2001; 13: 70–76.
11.
American Psychiatric Association. The Diagnostic and Statistical Manual of Mental Disorders: DSM 5. bookpointUS, 2013.
12.
BrownESKhanDANejtekVA. The psychiatric side effects of corticosteroids. Ann Allergy Asthma Immunol1999; 83: 495–504.
13.
MindenSLSchifferRB. Affective disorders in multiple sclerosis review and recommendations for clinical research. Arch Neurol1990; 47: 98–104.
14.
ButlerMACorboyJRFilleyCM. How the conflict between American psychiatry and neurology delayed the appreciation of cognitive dysfunction in multiple sclerosis. Neuropsychol Rev2009; 19: 399–410.
